Anders HJ. Immune system modulation of kidney regeneration–mechanisms and implications. Nat Rev Nephrol. 2014;10:347–58.

Article  CAS  PubMed  Google Scholar 

Andre C, Bodeau S, Kamel S, Bennis Y, Caillard P. The AKI-to-CKD transition: the role of Uremic Toxins. Int J Mol Sci 2023; 24.

Aziz M, Brenner M, Wang P. Extracellular CIRP (eCIRP) and inflammation. J Leukoc Biol. 2019;106:133–46.

Article  CAS  PubMed  Google Scholar 

Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Rossing P, Kolkhof P, Nowack C, Schloemer P, Joseph A, Filippatos G, Investigators F-D. Effect of Finerenone on chronic kidney Disease outcomes in type 2 diabetes. N Engl J Med. 2020;383:2219–29.

Article  CAS  PubMed  Google Scholar 

Bolourani S, Sari E, Brenner M, Wang P. Extracellular CIRP induces an inflammatory phenotype in pulmonary fibroblasts via TLR4. Front Immunol. 2021;12:721970.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bottinger EP, Bitzer M. TGF-beta signaling in renal disease. J Am Soc Nephrol. 2002;13:2600–10.

Article  PubMed  Google Scholar 

Breyer MD, Susztak K. The next generation of therapeutics for chronic kidney disease. Nat Rev Drug Discov. 2016;15:568–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carew RM, Wang B, Kantharidis P. The role of EMT in renal fibrosis. Cell Tissue Res. 2012;347:103–16.

Article  CAS  PubMed  Google Scholar 

Cen C, Yang WL, Yen HT, Nicastro JM, Coppa GF, Wang P. Deficiency of cold-inducible ribonucleic acid-binding protein reduces renal injury after ischemia-reperfusion. Surgery. 2016;160:473–83.

Article  PubMed  Google Scholar 

de Jesus Soares T, Volpini RA, Francescato HD, Costa RS, da Silva CG, Coimbra TM. Effects of resveratrol on glycerol-induced renal injury. Life Sci. 2007;81:647–56.

Article  PubMed  Google Scholar 

Denning NL, Yang WL, Hansen L, Prince J, Wang P. C23, an oligopeptide derived from cold-inducible RNA-binding protein, suppresses inflammation and reduces lung injury in neonatal sepsis. J Pediatr Surg. 2019;54:2053–60.

Article  PubMed  PubMed Central  Google Scholar 

Denning NL, Aziz M, Murao A, Gurien SD, Ochani M, Prince JM, Wang P. Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis. JCI Insight 2020; 5.

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B. 3rd, Stockwell BR. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duffield JS. Cellular and molecular mechanisms in kidney fibrosis. J Clin Invest. 2014;124:2299–306.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Falke LL, Gholizadeh S, Goldschmeding R, Kok RJ, Nguyen TQ. Diverse origins of the myofibroblast-implications for kidney fibrosis. Nat Rev Nephrol. 2015;11:233–44.

Article  CAS  PubMed  Google Scholar 

Fattah H, Layton A, Vallon V. How do kidneys adapt to a deficit or loss in nephron number? Physiol (Bethesda). 2019;34:189–97.

CAS  Google Scholar 

Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O’Donnell VB, Kagan VE, Schick JA, Conrad M. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014;16:1180–91.

Article  CAS  PubMed  Google Scholar 

Glassock RJ, Warnock DG, Delanaye P. The global burden of chronic kidney disease: estimates, variability and pitfalls. Nat Rev Nephrol. 2017;13:104–14.

Article  CAS  PubMed  Google Scholar 

Grande MT, Sanchez-Laorden B, Lopez-Blau C, De Frutos CA, Boutet A, Arevalo M, Rowe RG, Weiss SJ, Lopez-Novoa JM, Nieto MA. Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. Nat Med. 2015;21:989–97.

Article  CAS  PubMed  Google Scholar 

Guo R, Duan J, Pan S, Cheng F, Qiao Y, Feng Q, Liu D, Liu Z. The Road from AKI to CKD: Molecular mechanisms and therapeutic targets of Ferroptosis. Cell Death Dis. 2023;14:426.

Article  PubMed  PubMed Central  Google Scholar 

Heerspink HJL, Stefansson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, Mann JFE, McMurray JJV, Lindberg M, Rossing P, Sjostrom CD, Toto RD, Langkilde AM, Wheeler DC. Committees D-CT, investigators. Dapagliflozin in patients with chronic kidney disease. N Engl J Med. 2020;383:1436–46.

Article  CAS  PubMed  Google Scholar 

Hu Z, Zhang F, Brenner M, Jacob A, Wang P. The protective effect of H151, a novel STING inhibitor, in renal ischemia-reperfusion-induced acute kidney injury. Am J Physiol Ren Physiol. 2023;324:F558–67.

Article  CAS  Google Scholar 

Ide S, Kobayashi Y, Ide K, Strausser SA, Abe K, Herbek S, O’Brien LL, Crowley SD, Barisoni L, Tata A, Tata PR, Souma T. Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair. Elife 2021; 10.

Klingberg F, Hinz B, White ES. The myofibroblast matrix: implications for tissue repair and fibrosis. J Pathol. 2013;229:298–309.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Paton J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamori JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R. Decoding myofibroblast origins in human kidney fibrosis. Nature. 2021;589:281–6.

Article  CAS  PubMed  Google Scholar 

LeBleu VS, Taduri G, O’Connell J, Teng Y, Cooke VG, Woda C, Sugimoto H, Kalluri R. Origin and function of myofibroblasts in kidney fibrosis. Nat Med. 2013;19:1047–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lech M, Grobmayr R, Ryu M, Lorenz G, Hartter I, Mulay SR, Susanti HE, Kobayashi KS, Flavell RA, Anders HJ. Macrophage phenotype controls long-term AKI outcomes–kidney regeneration versus atrophy. J Am Soc Nephrol. 2014;25:292–304.

Article  CAS  PubMed  Google Scholar 

Lever JM, Hull TD, Boddu R, Pepin ME, Black LM, Adedoyin OO, Yang Z, Traylor AM, Jiang Y, Li Z, Peabody JE, Eckenrode HE, Crossman DK, Crowley MR, Bolisetty S, Zimmerman KA, Wende AR, Mrug M, Yoder BK, Agarwal A, George JF. Resident macrophages reprogram toward a developmental state after acute kidney injury. JCI Insight 2019; 4.

Li L, Ye H, Chen Q, Wei L. COL28 promotes proliferation, migration, and EMT of renal tubular epithelial cells. Ren Fail. 2023;45:2187236.

Article  PubMed  PubMed Central  Google Scholar 

Lin SL, Kisseleva T, Brenner DA, Duffield JS. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol. 2008;173:1617–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Wang J. Ferroptosis, a rising force against Renal Fibrosis. Oxid Med Cell Longev. 2022;2022:7686956.

Article  PubMed  PubMed Central  Google Scholar 

Lovisa S, LeBleu VS, Tampe B, Sugimoto H, Vadnagara K, Carstens JL, Wu CC, Hagos Y, Burckhardt BC, Pentcheva-Hoang T, Nischal H, Allison JP, Zeisberg M, Kalluri R. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nat Med. 2015;21:998–1009.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McGinn J, Zhang F, Aziz M, Yang WL, Nicastro J, Coppa GF, Wang P. The Protective Effect of a short peptide derived from Cold-Inducible RNA-Binding protein in Renal Ischemia-Reperfusion Injury. Shock. 2018;49:269–76.

Article  CAS  PubMed  PubMed Central