Bao R, Wang W, Chen B, Pan J, Chen Q, Liu M, et al. Dioscin ameliorates Hyperuricemia-Induced atherosclerosis by modulating of cholesterol metabolism through FXR-Signaling pathway. Nutrients. 2022;14(9):1983. https://doi.org/10.3390/nu14091983.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart Disease and Stroke Statistics-2017 update: a Report from the American Heart Association. Circulation. 2017;135(10):e146–603. https://doi.org/10.1161/CIR.0000000000000485.

Article  PubMed  PubMed Central  Google Scholar 

Boden WE, O’Rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk WJ, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007;356(15):1503–16. https://doi.org/10.1056/NEJMoa070829.

Article  CAS  PubMed  Google Scholar 

Cao Y, Luo F, Peng J, Fang Z, Liu Q, Zhou S. KMT2B-dependent RFK transcription activates the TNF-alpha/NOX2 pathway and enhances ferroptosis caused by myocardial ischemia-reperfusion. J Mol Cell Cardiol. 2022;173:75–91. https://doi.org/10.1016/j.yjmcc.2022.09.003.

Article  CAS  PubMed  Google Scholar 

Chen QM. Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury. Free Radic Biol Med. 2022;179:133–43. https://doi.org/10.1016/j.freeradbiomed.2021.12.001.

Article  CAS  PubMed  Google Scholar 

Chen D, Fan Z, Rauh M, Buchfelder M, Eyupoglu IY, Savaskan N. ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner. Oncogene. 2017;36(40):5593–608. https://doi.org/10.1038/onc.2017.146.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Li J, Kang R, Klionsky DJ, Tang D. Ferroptosis: machinery and regulation. Autophagy. 2021a;17(9):2054–81. https://doi.org/10.1080/15548627.2020.1810918.

Article  CAS  PubMed  Google Scholar 

Chen Y, Fan H, Wang S, Tang G, Zhai C, Shen L, Ferroptosis. A Novel Therapeutic Target for Ischemia-Reperfusion Injury. Front Cell Dev Biol. 2021b;9:688605. https://doi.org/10.3389/fcell.2021.688605.

Chen Z, Yan Y, Qi C, Liu J, Li L, Wang J. The role of ferroptosis in Cardiovascular Disease and its therapeutic significance. Front Cardiovasc Med. 2021c;8:733229. https://doi.org/10.3389/fcvm.2021.733229.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Collaboration AT. Collaborative overview of randomised trials of antiplatelet therapy–I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists’ Collab BMJ. 1994;308(6921):81–106.

Google Scholar 

Daniels Gatward LF, Kim Y, Loe A, Liu Y, Kristensen L, King AJF. Beta cell endoplasmic reticulum stress drives diabetes in the KINGS mouse without causing mass beta cell loss. Diabet Med. 2022;39(12):e14962. https://doi.org/10.1111/dme.14962.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de la Calle CM, Shee K, Yang H, Lonergan PE, Nguyen HG. The endoplasmic reticulum stress response in prostate cancer. Nat Rev Urol. 2022;19(12):708–26. https://doi.org/10.1038/s41585-022-00649-3.

Article  CAS  PubMed  Google Scholar 

Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife. 2014;3:e02523. https://doi.org/10.7554/eLife.02523.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo Y, Zhang W, Zhou X, Zhao S, Wang J, Guo Y, et al. Roles of ferroptosis in Cardiovascular diseases. Front Cardiovasc Med. 2022;9:911564. https://doi.org/10.3389/fcvm.2022.911564.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He J, Liu D, Zhao L, Zhou D, Rong J, Zhang L, et al. Myocardial ischemia/reperfusion injury: mechanisms of injury and implications for management (review). Exp Ther Med. 2022;23(6):430. https://doi.org/10.3892/etm.2022.11357.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu H, Chen Y, Jing L, Zhai C. The Link between Ferroptosis and Cardiovascular diseases: a novel target for treatment. Front Cardiovasc Med. 2021;8:710963. https://doi.org/10.3389/fcvm.2021.710963.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin S, Zhu T, Deng S, Li D, Li J, Liu X, et al. Dioscin ameliorates cisplatin-induced intestinal toxicity by mitigating oxidative stress and inflammation. Int Immunopharmacol. 2022;111:109111. https://doi.org/10.1016/j.intimp.2022.109111.

Article  CAS  PubMed  Google Scholar 

Kim JH, Najy AJ, Li J, Luo X, Kim HC, Choudry MHA, et al. Involvement of bid in the crosstalk between ferroptotic agent-induced ER stress and TRAIL-induced apoptosis. J Cell Physiol. 2022;237(11):4180–96. https://doi.org/10.1002/jcp.30863.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim H, Villareal LB, Liu Z, Haneef M, Falcon DM, Martin DR, et al. Transferrin receptor-mediated Iron Uptake promotes Colon tumorigenesis. Adv Sci (Weinh). 2023;10(10):e2207693. https://doi.org/10.1002/advs.202207693.

Article  CAS  PubMed  Google Scholar 

Komai K, Kawasaki NK, Higa JK, Matsui T. The role of ferroptosis in adverse left ventricular remodeling following Acute myocardial infarction. Cells. 2022;11(9):1399. https://doi.org/10.3390/cells11091399.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kong C, Lyu D, He C, Li R, Lu Q. Dioscin elevates lncRNA MANTIS in therapeutic angiogenesis for heart diseases. Aging Cell. 2021;20(7):e13392. https://doi.org/10.1111/acel.13392.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 2021;12(8):599–620. https://doi.org/10.1007/s13238-020-00789-5.

Article  CAS  PubMed  Google Scholar 

Kotseva K, De Bacquer D, De Backer G, Ryden L, Jennings C, Gyberg V, et al. Lifestyle and risk factor management in people at high risk of cardiovascular disease. A report from the European Society of Cardiology European Action on Secondary and Primary Prevention by intervention to reduce events (EUROASPIRE) IV cross-sectional survey in 14 European regions. Eur J Prev Cardiol. 2016;23(18):2007–18. https://doi.org/10.1177/2047487316667784.

Article  PubMed  Google Scholar 

Li JY, Liu SQ, Yao RQ, Tian YP, Yao YM. A Novel Insight into the Fate of cardiomyocytes in Ischemia-Reperfusion Injury: from Iron metabolism to Ferroptosis. Front Cell Dev Biol. 2021;9:799499. https://doi.org/10.3389/fcell.2021.799499.

Article  PubMed  PubMed Central  Google Scholar 

Li J, Xu L, Zuo YX, Chang XQ, Chi HT. Potential intervention target of atherosclerosis: ferroptosis (review). Mol Med Rep. 2022;26(5):343. https://doi.org/10.3892/mmr.2022.12859.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang Y, Liu Z, Qu L, Wang Y, Zhou Y, Liang L, et al. Inhibition of the IRE1/JNK pathway in renal tubular epithelial cells attenuates ferroptosis in acute kidney injury. Front Pharmacol. 2022;13:927641. https://doi.org/10.3389/fphar.2022.927641.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu A, Zhang W, Wang S, Wang Y, Hong J. HMGB-1/RAGE signaling inhibition by dioscin attenuates hippocampal neuron damage induced by oxygen-glucose deprivation/reperfusion. Exp Ther Med. 2020;20(6):231. https://doi.org/10.3892/etm.2020.9361.

Article  CAS  PubMed  PubMed Central