Mantovani F, Collavin L, Del Sal G (2019) Mutant p53 as a guardian of the cancer cell. Cell Death Differ 26:199–212
Hall C, Muller PAJ (2019) The diverse functions of mutant 53, its family members and isoforms in cancer. Int J Mol Sci 20:6188
Article CAS PubMed PubMed Central Google Scholar
Blandino G, Di Agostino S (2018) New therapeutic strategies to treat human cancers expressing mutant p53 proteins. J Exp Clin Cancer Res CR 37:30
Kennedy MC, Lowe SW. Mutant p53: it’s not all one and the same. Cell Death Differ. 2022;
Zhu G, Pan C, Bei J-X, Li B, Liang C, Xu Y et al (2020) Mutant p53 in cancer progression and targeted therapies. Front Oncol 10:595187
Article PubMed PubMed Central Google Scholar
Sallman DA, DeZern AE, Garcia-Manero G, Steensma DP, Roboz GJ, Sekeres MA et al (2021) Eprenetapopt (APR-246) and azacitidine in TP53-mutant myelodysplastic syndromes. J Clin Oncol Off J Am Soc Clin Oncol 39:1584–1594
Hassin O, Oren M (2023) Drugging p53 in cancer: one protein, many targets. Nat Rev Drug Discov 22:127–144
Article CAS PubMed Google Scholar
Shi Y, Jin J, Ji W, Guan X (2018) Therapeutic landscape in mutational triple negative breast cancer. Mol Cancer 17:99
Article PubMed PubMed Central Google Scholar
Network CGA (2015) Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 517:576–582
Chow LQM (2020) Head and Neck Cancer. N Engl J Med 382:60–72
Article CAS PubMed Google Scholar
Di Agostino S, Strano S, Emiliozzi V, Zerbini V, Mottolese M, Sacchi A et al (2006) Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell 10:191–202
Di Agostino S, Sorrentino G, Ingallina E, Valenti F, Ferraiuolo M, Bicciato S et al (2016) YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins. EMBO Rep 17:188–201
Cordani M, Oppici E, Dando I, Butturini E, Dalla Pozza E, Nadal-Serrano M et al (2016) Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition. Mol Oncol 10:1008–1029
Article CAS PubMed PubMed Central Google Scholar
Pruszko M, Milano E, Forcato M, Donzelli S, Ganci F, Di Agostino S et al (2017) The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1. EMBO Rep 18:1331–1351
Article CAS PubMed PubMed Central Google Scholar
Valenti F, Fausti F, Biagioni F, Shay T, Fontemaggi G, Domany E et al (2011) Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop. Cell Cycle Georget Tex 10:4330–4340
Zhang C, Ni C, Lu H (2022) Polo-like kinase 2: from principle to practice. Front Oncol 12:956225
Article CAS PubMed PubMed Central Google Scholar
Hanan EJ, Fucini RV, Romanowski MJ, Elling RA, Lew W, Purkey HE et al (2008) Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg Med Chem Lett 18:5186–5189
Article CAS PubMed Google Scholar
Valenti F, Sacconi A, Ganci F, Grasso G, Strano S, Blandino G et al (2019) The miR-205-5p/BRCA1/RAD17 axis promotes genomic instability in head and neck squamous cell carcinomas. Cancers 11:1347
Article CAS PubMed PubMed Central Google Scholar
Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z (2017) GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res 45:W98-102
Article CAS PubMed Google Scholar
Bartha Á, Győrffy B. TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues. Int J Mol Sci. 2021;22:2622.
Tibor Fekete J, Győrffy B (2022) A unified platform enabling biomarker ranking and validation for 1562 drugs using transcriptomic data of 1250 cancer cell lines. Comput Struct Biotechnol J 20:2885–2894
Article CAS PubMed PubMed Central Google Scholar
Győrffy B (2023) Discovery and ranking of the most robust prognostic biomarkers in serous ovarian cancer. GeroScience 45:1889–1898
Article PubMed PubMed Central Google Scholar
Vanderdys V, Allak A, Guessous F, Benamar M, Read PW, Jameson MJ et al (2018) The neddylation inhibitor pevonedistat (MLN4924) suppresses and radiosensitizes head and neck squamous carcinoma cells and tumors. Mol Cancer Ther 17:368–380
Article CAS PubMed Google Scholar
Fleisher B, Lezeau J, Werkman C, Jacobs B, Ait-Oudhia S (2021) In vitro to clinical translation of combinatorial effects of doxorubicin and abemaciclib in Rb-positive triple negative breast cancer: a systems-based pharmacokinetic/pharmacodynamic modeling approach. Breast Cancer Dove Med Press 13:87–105
CAS PubMed PubMed Central Google Scholar
Manna S, Holz MK (2016) Tamoxifen action in ER-negative breast cancer. Signal Transduct Insights 5:1–7
Rozeboom AM, Pak DTS (2012) Identification and functional characterization of polo-like kinase 2 autoregulatory sites. Neuroscience 202:147–157
Article CAS PubMed Google Scholar
Vijayakumaran R, Tan KH, Miranda PJ, Haupt S, Haupt Y (2015) Regulation of mutant p53 protein expression. Front Oncol 5:284
Article PubMed PubMed Central Google Scholar
Yamamoto S, Iwakuma T (2018) Regulators of oncogenic mutant TP53 gain of function. Cancers 11:4
Article PubMed PubMed Central Google Scholar
Hanel W, Moll UM (2012) Links between mutant p53 and genomic instability. J Cell Biochem 113:433–439
Article CAS PubMed PubMed Central Google Scholar
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z et al (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303:844–848
Article CAS PubMed Google Scholar
Ma S, Charron J, Erikson RL (2003) Role of Plk2 (Snk) in mouse development and cell proliferation. Mol Cell Biol 23:6936–6943
Article CAS PubMed PubMed Central Google Scholar
Kyuno D, Takasawa A, Kikuchi S, Takemasa I, Osanai M, Kojima T (2021) Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells. Biochim Biophys Acta BBA - Biomembr 1863:183503
Campisi J, Andersen JK, Kapahi P, Melov S (2011) Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol 21:354–359
CAS PubMed PubMed Central Google Scholar
Wagner K-D, Wagner N (2022) The senescence markers p16INK4A, p14ARF/p19ARF, and p21 in organ development and homeostasis. Cells 11:1966
留言 (0)