Long H et al (2022) Prevalence trends of site-specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019. Arthritis Rheumatol 74:1172–1183. https://doi.org/10.1002/art.42089
Article PubMed PubMed Central Google Scholar
Chen D et al (2017) Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res 5:16044. https://doi.org/10.1038/boneres.2016.44
Article CAS PubMed PubMed Central Google Scholar
Mobasheri A et al (2019) Recent advances in understanding the phenotypes of osteoarthritis. F1000Res 8. https://doi.org/10.12688/f1000research.20575.1
Cai C, Hu W, Chu T (2021) Interplay between iron overload and osteoarthritis: clinical significance and cellular mechanisms. Front Cell Dev Biol 9:817104. https://doi.org/10.3389/fcell.2021.817104
Xu J et al (2022) Genetic Causal association between iron status and osteoarthritis: a two-sample Mendelian randomization. Nutrients 14:3683
Article CAS PubMed PubMed Central Google Scholar
Dev S, Babitt JL (2017) Overview of iron metabolism in health and disease. Hemodial Int 21(Suppl 1):S6–S20. https://doi.org/10.1111/hdi.12542
Article PubMed PubMed Central Google Scholar
Widmaier, E. P. Vander’s human physiology : the mechanisms of body function. 12th ed. / Eric P. Widmaier, Hershel Raff, Kevin T. Strang. edn, (McGraw-Hill, 2011).
Ganz T (2013) Systemic iron homeostasis. Physiol Rev 93:1721–1741. https://doi.org/10.1152/physrev.00008.2013
Article CAS PubMed Google Scholar
Hentze MW, Muckenthaler MU, Andrews NC (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell 117:285–297. https://doi.org/10.1016/s0092-8674(04)00343-5
Article CAS PubMed Google Scholar
Lieu PT, Heiskala M, Peterson PA, Yang Y (2001) The roles of iron in health and disease. Mol Asp Med 22:1–87. https://doi.org/10.1016/S0098-2997(00)00006-6
Lane DJR et al (2015) Cellular iron uptake, trafficking and metabolism: key molecules and mechanisms and their roles in disease. Biochimica et Biophysica Acta (BBA)-Mol Cell Res 1853:1130–1144. https://doi.org/10.1016/j.bbamcr.2015.01.021
Crielaard BJ, Lammers T, Rivella S (2017) Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. https://doi.org/10.1038/nrd.2016.248
Article PubMed PubMed Central Google Scholar
Lepetsos P, Papavassiliou AG (2016) ROS/oxidative stress signaling in osteoarthritis. Biochimica et Biophysica Acta (BBA) - Mol Basis Dis 1862:576–591. https://doi.org/10.1016/j.bbadis.2016.01.003
Wang CY, Babitt JL (2019) Liver iron sensing and body iron homeostasis. Blood 133:18–29. https://doi.org/10.1182/blood-2018-06-815894
Article CAS PubMed PubMed Central Google Scholar
Tomas Dallos JZ Laszlo Kovacs. in Gerontorheumatology (ed Jozef Rovensky) Ch. 14, 139–149 (Springer International Publishing, 2017)
Corradini E, Buzzetti E, Pietrangelo A (2020) Genetic iron overload disorders. Mol Asp Med 75:100896. https://doi.org/10.1016/j.mam.2020.100896
Valenti L et al (2008) The hand arthropathy of hereditary hemochromatosis is strongly associated with iron overload. J Rheumatol 35:153–158
Carroll GJ, Sharma G, Upadhyay A, Jazayeri JA (2010) Ferritin concentrations in synovial fluid are higher in osteoarthritis patients with HFE gene mutations (C282Y or H63D). Scand J Rheumatol 39:413–420. https://doi.org/10.3109/03009741003677449
Article CAS PubMed Google Scholar
Ledesma-Colunga MG et al (2023) Transferrin receptor 2 deficiency promotes macrophage polarization and inflammatory arthritis. Redox Biol 60:102616. https://doi.org/10.1016/j.redox.2023.102616
Article CAS PubMed PubMed Central Google Scholar
Simão M et al (2019) Intracellular iron uptake is favored in Hfe-KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype. BioFactors 45:583–597. https://doi.org/10.1002/biof.1520
Article CAS PubMed Google Scholar
Zhou XY et al (1998) HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci U S A 95:2492–2497. https://doi.org/10.1073/pnas.95.5.2492
Article CAS PubMed PubMed Central Google Scholar
Ajioka RS, Levy JE, Andrews NC, Kushner JP (2002) Regulation of iron absorption in Hfe mutant mice. Blood 100:1465–1469. https://doi.org/10.1182/blood-2001-11-0037
Article CAS PubMed Google Scholar
Wallace DF, Summerville L, Lusby PE, Subramaniam VN (2005) First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut 54:980–986. https://doi.org/10.1136/gut.2004.062018
Article CAS PubMed PubMed Central Google Scholar
Rishi G, Secondes ES, Nathan Subramaniam V (2018) Hemochromatosis: evaluation of the dietary iron model and regulation of hepcidin. Biochimica et Biophysica Acta (BBA) - Mol Basis Dis 1864:2550–2556. https://doi.org/10.1016/j.bbadis.2018.05.005
Corradini E et al (2011) Iron regulation of hepcidin despite attenuated Smad 1,5,8 signaling in mice without transferrin receptor 2 or Hfe. Gastroenterology 141:1907–1914. https://doi.org/10.1053/j.gastro.2011.06.077
Article CAS PubMed Google Scholar
Miranda CJ et al (2003) Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. Blood 102:2574–2580. https://doi.org/10.1182/blood-2003-03-0869
Article CAS PubMed Google Scholar
Hawula ZJ, Secondes ES, Wallace DF, Rishi G, Subramaniam VN (2021) The effect of the flavonol rutin on serum and liver iron content in a genetic mouse model of iron overload. Biosci Rep 41. https://doi.org/10.1042/bsr20210720
Fan X et al (2022) The deterioration of calcified cartilage integrity reflects the severity of osteoarthritis—a structural, molecular, and biochemical analysis. The FASEB J 36:e22142. https://doi.org/10.1096/fj.202101449R
Article CAS PubMed Google Scholar
Sekar S et al (2017) Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats. Sci Rep 7:46457. https://doi.org/10.1038/srep46457
Article CAS PubMed PubMed Central Google Scholar
Sun AR et al (2019) Pro-resolving lipid mediator ameliorates obesity induced osteoarthritis by regulating synovial macrophage polarisation. Sci Rep 9:426. https://doi.org/10.1038/s41598-018-36909-9
Article CAS PubMed PubMed Central Google Scholar
Sun AR et al (2021) Effects of diet induced weight reduction on cartilage pathology and inflammatory mediators in the joint tissues. Front Med 8. https://doi.org/10.3389/fmed.2021.628843
Krenn V et al (2006) Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology 49:358–364. https://doi.org/10.1111/j.1365-2559.2006.02508.x
Article CAS PubMed Google Scholar
The importance of connexin hemichannels during chondroprogenitor cell differentiation in hydrogel versus microtissue culture models. Tissue Engineering Part A 21:1785–1794 (2015). https://doi.org/10.1089/ten.tea.2014.0691
Camacho A et al (2016) Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress. Osteoarthritis and Cartilage 24:494–502. https://doi.org/10.1016/j.joca.2015.09.007
留言 (0)