Integrating natural commensals and pathogens into preclinical mouse models

Dethlefsen, L., McFall-Ngai, M. & Relman, D. A. An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature 449, 811–818 (2007).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Virgin, H. W., Wherry, E. J. & Ahmed, R. Redefining chronic viral infection. Cell 138, 30–50 (2009).

Article  PubMed  CAS  Google Scholar 

Welsh, R. M., Che, J. W., Brehm, M. A. & Selin, L. K. Heterologous immunity between viruses. Immunol. Rev. 235, 244–266 (2010).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Weldon, L. et al. The gut microbiota of wild mice. PLoS One 10, e0134643 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Abolins, S. et al. The comparative immunology of wild and laboratory mice, Mus musculus domesticus. Nat. Commun. 8, 14811 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Abolins, S. et al. The ecology of immune state in a wild mammal, Mus musculus domesticus. PLoS Biol. 16, e2003538 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Liu, Q. et al. Leveraging dirty mice that have microbial exposure to improve preclinical models of human immune status and disease. Nat. Immunol. 25, 947–950 (2024).

Article  PubMed  CAS  Google Scholar 

Suzuki, T. A. et al. Codiversification of gut microbiota with humans. Science 377, 1328–1332 (2022).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sanders, J. G. et al. Widespread extinctions of co-diversified primate gut bacterial symbionts from humans. Nat. Microbiol. 8, 1039–1050 (2023).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Carter, M. M. et al. Ultra-deep sequencing of Hadza hunter-gatherers recovers vanishing gut microbes. Cell 186, 3111–3124.e13 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Vangay, P. et al. US immigration westernizes the human gut microbiome. Cell 175, 962–972.e10 (2018).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rothschild, D. et al. Environment dominates over host genetics in shaping human gut microbiota. Nature 555, 210–215 (2018).

Article  PubMed  CAS  Google Scholar 

Vujkovic-Cvijin, I. et al. Host variables confound gut microbiota studies of human disease. Nature 587, 448–454 (2020).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Linz, B. et al. An African origin for the intimate association between humans and Helicobacter pylori. Nature 445, 915–918 (2007).

Article  PubMed  PubMed Central  Google Scholar 

Stacy, A. et al. Infection trains the host for microbiota-enhanced resistance to pathogens. Cell 184, 615–627.e17 (2021).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fenneman, A. C., Weidner, M., Chen, L. A., Nieuwdorp, M. & Blaser, M. J. Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract. Nat. Rev. Gastroenterol. Hepatol. 20, 81–100 (2023).

Article  PubMed  Google Scholar 

Levin, D. et al. Diversity and functional landscapes in the microbiota of animals in the wild. Science 372, eabb5352 (2021).

Article  PubMed  CAS  Google Scholar 

Tung, J. et al. Social networks predict gut microbiome composition in wild baboons. eLife 4, e05224 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Sarkar, A. et al. Microbial transmission in the social microbiome and host health and disease. Cell 187, 17–43 (2024).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Marsh, K. J. et al. Synchronous seasonality in the gut microbiota of wild mouse populations. Front. Microbiol. 13, 809735 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Reese, A. T. et al. Effects of domestication on the gut microbiota parallel those of human industrialization. eLife 10, e60197 (2021).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sheldon, B. C. & Verhulst, S. Ecological immunology: costly parasite defences and trade-offs in evolutionary ecology. Trends Ecol. Evol. 11, 317–321 (1996).

Article  PubMed  CAS  Google Scholar 

Babayan, S. A. et al. Wild immunology: converging on the real world. Ann. N. Y. Acad. Sci. 1236, 17–29 (2011).

Article  PubMed  CAS  Google Scholar 

Flies, A. S. & Wild Comparative Immunology Consortium. Rewilding immunology. Science 369, 37–38 (2020).

Article  PubMed  CAS  Google Scholar 

French, S. S., Johnston, G. I. H. & Moore, M. C. Immune activity suppresses reproduction in food-limited female tree lizards Urosaurus ornatus. Funct. Ecol. 21, 1115–1122 (2007).

Article  Google Scholar 

Stockmaier, S., Dechmann, D. K., Page, R. A. & O’Mara, M. T. No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat. Biol. Lett. 11, 20150576 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Graham, A. L. et al. Fitness correlates of heritable variation in antibody responsiveness in a wild mammal. Science 330, 662–665 (2010).

Article  PubMed  CAS  Google Scholar 

Leivesley, J. A. et al. Survival costs of reproduction are mediated by parasite infection in wild Soay sheep. Ecol. Lett. 22, 1203–1213 (2019).

Article  PubMed  Google Scholar 

Viney, M., Lazarou, L. & Abolins, S. The laboratory mouse and wild immunology. Parasite Immunol. 37, 267–273 (2015).

Article  PubMed  CAS  Google Scholar 

Link, V. M. et al. Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans. Nat. Med. 30, 560–572 (2024).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Artwohl, J. E., Cera, L. M., Wright, M. F., Medina, L. V. & Kim, L. J. The efficacy of a dirty bedding sentinel system for detecting Sendai virus infection in mice: a comparison of clinical signs and seroconversion. Lab. Anim. Sci. 44, 73–75 (1994).

PubMed  CAS  Google Scholar 

Graham, A. L. Naturalizing mouse models for immunology. Nat. Immunol. 22, 111–117 (2021).

Article  PubMed  CAS 

留言 (0)

沒有登入
gif