IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs

Pinho, S. & Frenette, P. S. Haematopoietic stem cell activity and interactions with the niche. Nat. Rev. Mol. Cell Biol. 20, 303–320 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chua, B. A., Van Der Werf, I., Jamieson, C. & Signer, R. A. J. Post-transcriptional regulation of homeostatic, stressed, and malignant stem cells. Cell Stem Cell 26, 138–159 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clarke, M. L. et al. MYB insufficiency disrupts proteostasis in hematopoietic stem cells, leading to age-related neoplasia. Blood 141, 1858–1870 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herrejon Chavez, F. et al. RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nat. Commun. 14, 2290 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Signer, R. A., Magee, J. A., Salic, A. & Morrison, S. J. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature 509, 49–54 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Labbadia, J. & Morimoto, R. I. The biology of proteostasis in aging and disease. Annu. Rev. Biochem. 84, 435–464 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hetz, C., Zhang, K. & Kaufman, R. J. Mechanisms, regulation and functions of the unfolded protein response. Nat. Rev. Mol. Cell Biol. 21, 421–438 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calfon, M. et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415, 92–96 (2002).

Article  CAS  PubMed  Google Scholar 

Yoshida, H., Matsui, T., Yamamoto, A., Okada, T. & Mori, K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881–891 (2001).

Article  CAS  PubMed  Google Scholar 

Nakamura-Ishizu, A., Ito, K. & Suda, T. Hematopoietic stem cell metabolism during development and aging. Dev. Cell 54, 239–255 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bettigole, S. E. et al. The transcription factor XBP1 is selectively required for eosinophil differentiation. Nat. Immunol. 16, 829–837 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Galen, P. et al. The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress. Nature 510, 268–272 (2014).

Article  PubMed  Google Scholar 

Cubillos-Ruiz, J. R., Bettigole, S. E. & Glimcher, L. H. Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer. Cell 168, 692–706 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun, H. et al. Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget 7, 18736–18749 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Schardt, J. A., Weber, D., Eyholzer, M., Mueller, B. U. & Pabst, T. Activation of the unfolded protein response is associated with favorable prognosis in acute myeloid leukemia. Clin. Cancer Res. 15, 3834–3841 (2009).

Article  CAS  PubMed  Google Scholar 

Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3, 730–737 (1997).

Article  CAS  PubMed  Google Scholar 

Shlush, L. I. et al. Tracing the origins of relapse in acute myeloid leukaemia to stem cells. Nature 547, 104–108 (2017).

Article  CAS  PubMed  Google Scholar 

Thomas, D. & Majeti, R. Biology and relevance of human acute myeloid leukemia stem cells. Blood 129, 1577–1585 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oguro, H., Ding, L. & Morrison, S. J. SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. Cell Stem Cell 13, 102–116 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iwawaki, T., Akai, R., Kohno, K. & Miura, M. A transgenic mouse model for monitoring endoplasmic reticulum stress. Nat. Med. 10, 98–102 (2004).

Article  CAS  PubMed  Google Scholar 

Cao, S. S. & Kaufman, R. J. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid. Redox Signal. 21, 396–413 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bedard, K. & Krause, K. H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev. 87, 245–313 (2007).

Article  CAS  PubMed  Google Scholar 

Pollock, J. D. et al. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat. Genet. 9, 202–209 (1995).

Article  CAS  PubMed  Google Scholar 

Chen, M. Z. et al. A thiol probe for measuring unfolded protein load and proteostasis in cells. Nat. Commun. 8, 474 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Lee, A. H., Iwakoshi, N. N. & Glimcher, L. H. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol. Cell. Biol. 23, 7448–7459 (2003).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee, B. H. et al. FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia. Cancer Cell 12, 367–380 (2007).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daver, N., Schlenk, R. F., Russell, N. H. & Levis, M. J. Targeting FLT3 mutations in AML: review of current knowledge and evidence. Leukemia 33, 299–312 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joseph, C. et al. Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies. Cell Stem Cell 13, 520–533 (2013).

Article  CAS  PubMed  Google Scholar 

Velasco-Hernandez, T., Sawen, P., Bryder, D. & Cammenga, J. Potential pitfalls of the Mx1-Cre system: implications for experimental modeling of normal and malignant hematopoiesis. Stem Cell Rep. 7, 11–18 (2016).

Article  CAS  Google Scholar 

Sprooten, J. & Garg, A. D. Type I interferons and endoplasmic reticulum stress in health and disease. Int. Rev. Cell Mol. Biol. 350, 63–118 (2020).

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