These authors contributed equally: Ruoyan Li, Johanna Strobl, Elizabeth F. M. Poyner, Aya Balbaa.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK

Ruoyan Li, Johanna Strobl, Aya Balbaa, Fereshteh Torabi, Pavel V. Mazin, Nana-Jane Chipampe, Emily Stephenson, Ciro Ramírez-Suástegi, Vijaya Baskar Mahalingam Shanmugiah, Rachel A. Botting, Elena Prigmore, Marta A. Chroscik, Efpraxia Kritikaki, Justin Engelbert, Issac Goh, Hon Man Chan, Harriet F. Johnson, Jasmine Ellis, Victoria Rowe, Win Tun, April Rose Foster, Laure Gambardella, Elena Winheim, Chloe Admane, Benjamin Rumney, Lloyd Steele, David Horsfall, Daniela Basurto-Lozada, Sarah A. Teichmann & Muzlifah Haniffa

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Ruoyan Li & Dexin Yang

MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA

Ruoyan Li & Dexin Yang

Department of Dermatology, Medical University of Vienna, Vienna, Austria

Johanna Strobl, Nina Zila & Constanze Jonak

Biosciences Institute, Newcastle University, Newcastle, UK

Elizabeth F. M. Poyner, Emily Stephenson, Louis Gardner, Bayanne Olabi, Rachel A. Botting, Nusayhah H. Gopee, Marta A. Chroscik, Efpraxia Kritikaki, Justin Engelbert, Issac Goh, Win Tun, Gary Reynolds, Chloe Admane, Laura Jardine, Keir Pickard, David Horsfall, Daniela Basurto-Lozada, Louise Grimble & Muzlifah Haniffa

Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle, Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

Elizabeth F. M. Poyner, Louis Gardner, Bayanne Olabi, Nusayhah H. Gopee, Philip Hampton, Sophie C. Weatherhead, Nick J. Reynolds & Muzlifah Haniffa

NovoPath, Department of Cellular Pathology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

Rowen Coulthard

Section Biomedical Science, University of Applied Sciences FH Campus Wien, Vienna, Austria

Nina Zila

Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA

Gary Reynolds

Division of Dermatology, Department of Medicine, Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden

Julia Nenonen & Hanna Brauner

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK

Jennifer Lumley & Nick J. Reynolds

Biomedical Pioneering Innovation Center and School of Life Sciences, Peking University, Beijing, China

Simeng Hu & Fan Bai

Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China

Fengjie Liu, Xiangjun Liu & Yang Wang

Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK

Chris M. Bacon

Department of Cellular Pathology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

Chris M. Bacon

Department of Dermatology, Karolinska University Hospital, Stockholm, Sweden

Hanna Brauner

Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

Judith E. Allen

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Patrick M. Brunner

Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK

Sarah A. Teichmann

Department of Medicine, University of Cambridge, Cambridge, UK

Sarah A. Teichmann