Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer

Inaba, K. et al. Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow. Proc. Natl Acad. Sci. USA 90, 3038–3042 (1993).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller, J. C. et al. Deciphering the transcriptional network of the dendritic cell lineage. Nat. Immunol. 13, 888–899 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Steinman, R. M., Hawiger, D. & Nussenzweig, M. C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21, 685–711 (2003).

Article  CAS  PubMed  Google Scholar 

Vestre, K. et al. Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton. J. Cell Sci. 134, jcs259221 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Randolph, G. J., Angeli, V. & Swartz, M. A. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat. Rev. Immunol. 5, 617–628 (2005).

Article  CAS  PubMed  Google Scholar 

Del Prete, A. et al. Dendritic cell subsets in cancer immunity and tumor antigen sensing. Cell. Mol. Immunol. 20, 432–447 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Park, M. D. et al. On the biology and therapeutic modulation of macrophages and dendritic cells in cancer. Annu. Rev. Cancer Biol. 7, 291–311 (2023).

Article  Google Scholar 

Tordesillas, L. et al. PDL2+ CD11b+ dermal dendritic cells capture topical antigen through hair follicles to prime LAP+ Tregs. Nat. Commun. 9, 5238 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, Y. et al. Regulation of T cell activation and tolerance by PDL2. Proc. Natl Acad. Sci. USA 103, 11695–11700 (2006).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oh, S. A. et al. PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer. Nat. Cancer 1, 681–691 (2020).

Article  CAS  PubMed  Google Scholar 

Peng, Q. et al. PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade. Nat. Commun. 11, 4835 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garris, C. S. et al. Successful anti-PD-1 cancer immunotherapy requires T cell–dendritic cell crosstalk involving the cytokines IFN-γ and IL-12. Immunity 49, 1148–1161 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martínez-López, M., Iborra, S., Conde-Garrosa, R. & Sancho, D. Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local TH1 immunity against Leishmania major infection in mice. Eur. J. Immunol. 45, 119–129 (2015).

Article  PubMed  Google Scholar 

Pulendran, B. et al. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc. Natl Acad. Sci. USA 96, 1036–1041 (1999).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reis e Sousa, C. et al. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186, 1819–1829 (1997).

Article  CAS  PubMed  Google Scholar 

Maier, B. et al. A conserved dendritic-cell regulatory program limits antitumour immunity. Nature 580, 257–262 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bosteels, V. et al. LXR signaling controls homeostatic dendritic cell maturation. Sci. Immunol. 8, eadd3955 (2023).

Article  CAS  PubMed  Google Scholar 

Binnewies, M. et al. Unleashing type-2 dendritic cells to drive protective antitumor CD4+ T cell immunity. Cell 177, 556–571 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bosteels, C. et al. Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection. Immunity 52, 1039–1056 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leader, A. M. et al. Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification. Cancer Cell 39, 1594–1609 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Magen, A. et al. Intratumoral dendritic cell-CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma. Nat. Med. 29, 1389–1399 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pelka, K. et al. Spatially organized multicellular immune hubs in human colorectal cancer. Cell 184, 4734–4752 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Steele, N. G. et al. Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer. Nat. Cancer 1, 1097–1112 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, Y. et al. Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer. Cancer Cell 39, 1578–1593 (2021).

Article  CAS  PubMed  Google Scholar 

Qian, J. et al. A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling. Cell Res. 30, 745–762 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gerhard, G. M., Bill, R., Messemaker, M., Klein, A. M. & Pittet, M. J. Tumor-infiltrating dendritic cell states are conserved across solid human cancers. J. Exp. Med. 218, e20200264 (2021).

Article  CAS  PubMed  Google Scholar 

Zhang, L. et al. Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer. Cell 181, 442–459 (2020).

Article  CAS  PubMed  Google Scholar 

Zilionis, R. et al. Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species. Immunity 50, 1317–1334 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ohno-Iwashita, Y. et al. Perfringolysin O, a cholesterol-binding cytolysin, as a probe for lipid rafts. Anaerobe 10, 125–134 (2004).

Article  CAS  PubMed  Google Scholar 

Shimada, Y., Maruya, M., Iwashita, S. & Ohno-Iwashita, Y. The C-terminal domain of perfringolysin O is an essential cholesterol-binding unit targeting to cholesterol-rich microdomains. Eur. J. Biochem. 269, 6195–6203 (2002).

Article  CAS 

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