Whitten S.T., García-Moreno E. B., Hilser V.J. 2005. Local conformational fluctuations can modulate the coupling between proton binding and global structural transitions in proteins. Proc. Nat. Acad. Sci. USA. 102 (12), 4282–4287.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baca J.M., Ortega A.O., Jiménez A.A., Principal S.G. 2022. Cells electric charge analyses define specific properties for cancer cells activity. Bioelectrochemistry. 144, 108028.

Article  Google Scholar 

Soto E., Ortega-Ramírez A., Vega R. 2018. Protons as messengers of intercellular communication in the nervous system. Front. Cell. Neurosci. 12, 342.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pattison L.A., Callejo G., St. John Smith E. 2019. Evolution of acid nociception: Ion channels and receptors for detecting acid. Philos. Trans. R. Soc. B. 374 (1785), 20190291.

Article  Google Scholar 

Ruffin V.A., Salameh A.I., Boron W.F., Parker M.D. 2014. Intracellular pH regulation by acid-base transporters in mammalian neurons. Front. Physiol. 5, 74282.

Article  Google Scholar 

Decoursey T.E. 2003. Voltage-gated proton channels and other proton transfer pathways. Physiol. Rev. 83 (2), 475–579.

Article  CAS  PubMed  Google Scholar 

DeCoursey T.E. 2018. Voltage and pH sensing by the voltage-gated proton channel, HV1. J. R. Soc. Interface 15 (141), 20180108.

Article  PubMed  PubMed Central  Google Scholar 

Hurle B., Ignatova E., Massironi S.M., Mashimo T., Rios X., Thalmann I., Thalmann R., Ornitz D.M. 2003. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Hum. Mol. Genet. 12 (7), 777–789.

Article  CAS  PubMed  Google Scholar 

Tu Y.H., Cooper A.J., Teng B., Chang R.B., Artiga D.J., Turner H.N., Mulhall E.M., Ye W., Smith A.D., Liman E.R. 2018. An evolutionarily conserved gene family encodes proton-selective ion channels. Science. 359,1047–1050.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hughes I., Saito M., Schlesinger P.H., Ornitz D.M. 2007. Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium. Proc. Nat. Acad. Sci. USA. 104 (29), 12023–12028.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim S., Ahn H., Kim D., Cho S.W., Kim S. 2024. OTOP1: A new candidate gene for non-syndromic peg lateralis. Res. Square.https://doi.org/10.21203/rs.3.rs-3811797/v1

Book  Google Scholar 

Tu Y.H., Liu N., Xiao C., Gavrilova O., Reitman M.L. 2023. Loss of Otopetrin 1 affects thermoregulation during fasting in mice. Plos One, 18 (10), e0292610.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang W.W., Matt A.S., Schewe M., Musinszki M., Grüssel S., Brandenburg J., Garfield D., Bleich M., Baukrowitz T., Hu M.Y. 2021. An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier. Proc. Nat. Acad. Sci. USA. 118 (30), e2101378118.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liman E.R., Kinnamon S.C. 2021. Sour taste: Receptors, cells and circuits. Curr. Opin. Physiol. 20, 8–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li B., Wang Y., Castro A., Ng C., Wang Z., Chaudhry H., Agbaje Z., Ulloa G.A., Yu Y. 2022. The roles of two extracellular loops in proton sensing and permeation in human Otop1 proton channel. Commun. Biol. 5, 1110.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taruno A., Nomura K., Kusakizako T., Ma Z., Nureki O., Foskett J.K. 2021. Taste transduction and channel synapses in taste buds. Pflugers Arch. 473, 3–13.

Article  CAS  PubMed  Google Scholar 

Yoshida R., Miyauchi A., Yasuo T., Jyotaki M., Murata Y., Yasumatsu K., Shigemura N., Yanagawa Y., Obata K., Ueno H., Margolskee R.F. 2009. Discrimination of taste qualities among mouse fungiform taste bud cells. J. Physiol. 587 (18), 4425–4439.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang R.B., Waters H., Liman E.R. 2010. A proton current drives action potentials in genetically identified sour taste cells. Proc. Nat. Acad. Sci. USA. 107 (51), 22320–22325.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Teng B., Wilson C.E., Tu Y.H., Joshi N.R., Kinnamon S.C., Liman E.R. 2019. Cellular and neural responses to sour stimuli require the proton channel Otop1. Curr. Biol. 29 (21), 3647–3656.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang Z., Wilson C.E., Teng B., Kinnamon S.C., Liman E.R. 2023. The proton channel OTOP1 is a sensor for the taste of ammonium chloride. Nat. Comm. 14 (1), 6194.

Article  CAS  Google Scholar 

Tian L., Zhang H., Yang S., Luo A., Kamau P.M., Hu J., Luo L., Lai R. 2023. Vertebrate OTOP1 is also an alkali-activated channel. Nat. Comm. 14 (1), 26.

Article  CAS  Google Scholar 

Sakmann B., Neher E., Ed. 2009. Single-channel recording. 2nd ed. New York; Dordreht; Heildelberg; London: Springer-Science and Business Media.

Machtens J.-Ph., Fahlke C., Kovermann P. 2011. Noise analysis to study unitary properties of transporter-associated ion channels. Channels. 5 (6). 468–474.

Article  CAS  PubMed  Google Scholar 

Teng B., Kaplan J.P., Liang Z., Chyung K.S., Goldschen-Ohm M.P., Liman E.R. 2023. Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus. Elife. 12, e85317.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bushman J.D., Ye W., Liman E.R. 2015. A proton current associated with sour taste: Distribution and functional properties. FASEB J. 29, 3014–3026.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hughes M.P. 2024. The cellular zeta potential: Cell electrophysiology beyond the membrane. Integr. Biol. 16, 1–11.

Article  Google Scholar 

Teng B., Kaplan J.P., Liang Z., Krieger Z., Tu Y.H., Burendei B., Ward A.B., Liman E.R. 2022. Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels. eLife 11, 77946.

Article  Google Scholar 

Hille B. 1992. Ionic channels of excitable membranes. 2nd ed. Sunderland: Sinauer Associates, Inc.

Google Scholar 

Ohtubo Y. 2021. Slow recovery from the inactivation of voltage-gated sodium channel Nav1.3 in mouse taste receptor cells. Pflügers Archiv. 473 (6), 953–968.

Article  CAS  PubMed  Google Scholar 

Saotome K., Teng B., Tsui C.C., Lee W.H., Tu Y.H., Kaplan J.P., Sansom M.S.P., Liman E.R., Ward A.B. 2019. Structures of the otopetrin proton channels Otop1 and Otop3. Nat. Struct. Mol. Biol. 26, 518–525.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q., Zeng W., She J., Bai X.C., Jiang Y. 2019. Structural and functional characterization of an otopetrin family proton channel. Elife. 8, e46710.

Article  PubMed  PubMed Central  Google Scholar 

Delemotte L. 2019. Outlining the proton-conduction pathway in otopetrin channels. Nat. Struct. Mol. Biol. 26 (7), 528–530.

Article  CAS