Aguirre-Lavin, T. et al. 3D-FISH analysis of embryonic nuclei in mouse highlights several abrupt changes of nuclear organization during preimplantation development. BMC Dev. Biol. 12, 30 (2012).
Article PubMed PubMed Central Google Scholar
Ahmed, K. et al. Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS ONE 5, e10531 (2010).
Article PubMed PubMed Central Google Scholar
Probst, A., Santos, F., Reik, W., Almouzni, G. & Dean, W. Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote. Chromosoma 116, 403–415 (2007).
Martin, C. et al. Genome restructuring in mouse embryos during reprogramming and early development. Dev. Biol. 292, 317–332 (2006).
Article CAS PubMed Google Scholar
Probst, A. et al. A strand-specific burst in transcription of pericentric satellites is required for chromocenter formation and early mouse development. Dev. Cell 19, 625–638 (2010).
Article CAS PubMed Google Scholar
Burton, A. & Torres-Padilla, M. Chromatin dynamics in the regulation of cell fate allocation during early embryogenesis. Nat. Rev. Mol. Cell Biol. 15, 723–735 (2014).
Article CAS PubMed Google Scholar
Tarkowski, A. K., Ozdzenski, W. & Czolowska, R. Identical triplets and twins developed from isolated blastomeres of 8- and 16-cell mouse embryos supported with tetraploid blastomeres. Int. J. Dev. Biol. 49, 825–832 (2005).
Li, L. et al. Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos. Nat. Struct. Mol. Biol. 31, 950–963 (2024).
Article CAS PubMed Google Scholar
Puschendorf, M. et al. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat. Genet. 40, 411–420 (2008).
Article CAS PubMed Google Scholar
Burton, A. et al. Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3. Nat. Cell Biol. 22, 767–778 (2020).
Article CAS PubMed PubMed Central Google Scholar
Wang, C. et al. Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development. Nat. Cell Biol. 20, 620–631 (2018).
Article CAS PubMed Google Scholar
Yang, H. et al. Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo. Nat. Cell Biol. 24, 783–792 (2022).
Article CAS PubMed Google Scholar
Fadloun, A. et al. Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA. Nat. Struct. Mol. Biol. 20, 332–338 (2013).
Article CAS PubMed Google Scholar
Hatanaka, Y. et al. Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons. Proc. Natl Acad. Sci. USA 112, 14641–14646 (2015).
Article CAS PubMed PubMed Central Google Scholar
Mochizuki, K. et al. Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing. Nat. Commun. 12, 7020–7015 (2021).
Article CAS PubMed PubMed Central Google Scholar
Zheng, H. et al. Resetting epigenetic memory by reprogramming of histone modifications in mammals. Mol. Cell 63, 1066–1079 (2016).
Article CAS PubMed Google Scholar
Mei, H. et al. H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos. Nat. Genet. 53, 539–550 (2021).
Article CAS PubMed Google Scholar
Loda, A., Collombet, S. & Heard, E. Gene regulation in time and space during X-chromosome inactivation. Nat. Rev. Mol. Cell Biol. 23, 231–249 (2022).
Article CAS PubMed Google Scholar
Hojfeldt, J. W. et al. Non-core subunits of the PRC2 complex are collectively required for its target-site specificity. Mol. Cell 76, 423–436 e423 (2019).
Healy, E. et al. PRC2.1 and PRC2.2 synergize to coordinate H3K27 trimethylation. Mol. Cell 76, 437–452.e436 (2019).
Article CAS PubMed Google Scholar
Kim, J. J. & Kingston, R. E. Context-specific Polycomb mechanisms in development. Nat. Rev. Genet. 23, 680–695 (2022).
Article CAS PubMed PubMed Central Google Scholar
Schuettengruber, B., Bourbon, H.-M., Di Croce, L. & Cavalli, G. Genome regulation by Polycomb and Trithorax: 70 years and counting. Cell 171, 34–57 (2017).
Article CAS PubMed Google Scholar
Blackledge, N. P. & Klose, R. J. The molecular principles of gene regulation by Polycomb repressive complexes. Nat. Rev. Mol. Cell Biol. 22, 815–833 (2021).
Article CAS PubMed PubMed Central Google Scholar
Li, H. et al. Polycomb-like proteins link the PRC2 complex to CpG islands. Nature 549, 287–291 (2017).
Article CAS PubMed PubMed Central Google Scholar
Perino, M. et al. MTF2 recruits Polycomb repressive complex 2 by helical-shape-selective DNA binding. Nat. Genet. 50, 1002–1010 (2018).
Article CAS PubMed Google Scholar
Pasini, D. et al. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464, 306–310 (2010).
Article CAS PubMed Google Scholar
Shen, X. et al. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell 139, 1303–1314 (2009).
Article PubMed PubMed Central Google Scholar
Li, G. et al. Jarid2 and PRC2, partners in regulating gene expression. Genes Dev. 24, 368–380 (2010).
Article PubMed PubMed Central Google Scholar
Kim, H., Kang, K. & Kim, J. AEBP2 as a potential targeting protein for Polycomb repression complex PRC2. Nucleic Acids Res. 37, 2940–2950 (2009).
Article CAS PubMed PubMed Central Google Scholar
Cooper, S. et al. Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat. Commun. 7, 1–8 (2016).
Kalb, R. et al. Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression. Nat. Struct. Mol. Biol. 21, 569–571 (2014).
Article CAS PubMed Google Scholar
Kasinath, V. et al. JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science 371, eabc3393-3311 (2021).
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