Dengue NS1 interaction with lipids alters its pathogenic effects on monocyte derived macrophages

Akey DL, Brown WC, Dutta S, Konwerski J, Jose J, Jurkiw TJ, DelProposto J, Ogata CM, Skiniotis G, Kuhn RJ, Smith JL. Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system. Science. 2014;343(6173):881–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alcon-LePoder S, Drouet MT, Roux P, Frenkiel MP, Arborio M, Durand-Schneider AM, Maurice M, Le Blanc I, Gruenberg J, Flamand M. The secreted form of dengue virus nonstructural protein NS1 is endocytosed by hepatocytes and accumulates in late endosomes: implications for viral infectivity. J Virol. 2005;79(17):11403–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alcon-LePoder S, Sivard P, Drouet MT, Talarmin A, Rice C, Flamand M. Secretion of flaviviral non-structural protein NS1: from diagnosis to pathogenesis. Novartis Found Symp. 2006;277:233–47 discussion 247–253.

Article  CAS  PubMed  Google Scholar 

Allonso D, Meneses MD, Fernandes CA, Ferreira DF, Mohana-Borges R. Assessing positivity and circulating levels of NS1 in samples from a 2012 dengue outbreak in Rio De Janeiro, Brazil. PLoS ONE. 2014;9(11):e113634.

Article  PubMed  PubMed Central  Google Scholar 

Artero-Castro A, Perez-Alea M, Feliciano A, Leal JA, Genestar M, Castellvi J, Peg V, Ramon YCS, Lleonart ME. Disruption of the ribosomal P complex leads to stress-induced autophagy. Autophagy. 2015;11(9):1499–519.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Avirutnan P, Fuchs A, Hauhart RE, Somnuke P, Youn S, Diamond MS, Atkinson JP. Antagonism of the complement component C4 by flavivirus nonstructural protein NS1. J Exp Med. 2010;207(4):793–806.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beatty PR, Puerta-Guardo H, Killingbeck SS, Glasner DR, Hopkins K, Harris E. Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination. Sci Transl Med. 2015;7(304):304ra141.

Article  PubMed  Google Scholar 

Benfrid S, Park KH, Dellarole M, Voss JE, Tamietti C, Pehau-Arnaudet G, Raynal B, Brule S, England P, Zhang X, Mikhailova A, Hasan M, Ungeheuer MN, Petres S, Biering SB, Harris E, Sakuntabhai A, Buchy P, Duong V, Dussart P, Coulibaly F, Bontems F, Rey FA, Flamand M. Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins. EMBO Rep. 2022;23(7):e53600.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI. The global distribution and burden of dengue. Nature. 2013;496(7446):504–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bos S, Graber AL, Cardona-Ospina JA, Duarte EM, Zambrana JV, Ruiz Salinas JA, Mercado-Hernandez R, Singh T, Katzelnick LC, de Silva A, Kuan G, Balmaseda A, Harris E. Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype. Nat Commun. 2024;15(1):382.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Breiman L. Random forests. Mach Learn. 2001;45:5–32.

Article  Google Scholar 

Campos RK, Wijeratne HRS, Shah P, Garcia-Blanco MA, Bradrick SS. Ribosomal stalk proteins RPLP1 and RPLP2 promote biogenesis of flaviviral and cellular multi-pass transmembrane proteins. Nucleic Acids Res. 2020;48(17):9872–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chancharoenthana W, Leelahavanichkul A, Ariyanon W, Vadcharavivad S, Phatcharophaswattanakul S, Kamolratanakul S, Leaungwutiwong P, Phumratanaprapin W, Wilairatana P. Leaky gut syndrome is associated with endotoxemia and serum (1–>3)-beta-D-glucan in severe dengue infection. Microorganisms. 2021;9:11.

Article  Google Scholar 

Chew BLA, Ngoh AQ, Phoo WW, Weng MJG, Sheng HJ, Chan KWK, Tan EYJ, Gelbart T, Xu C, Tan GS, Vasudevan SG, Luo D. Structural basis of Zika virus NS1 multimerization and human antibody recognition. npj Viruses. 2024;2(1):14.

Article  Google Scholar 

Chew BLA, Ngoh AQ, Phoo WW, Chan WKK, Ser Z, Lim SS, Weng MJG, Watanabe S, Choy MM, Low JG, Ooi EE, Sobota RM, Vasudevan SG, Luo D. Secreted dengue virus NS1 is predominantly dimeric and in complex with high-density lipoprotein. eLife. 2022;12:RP90762.

Dayarathna S, Jeewandara C, Gomes L, Somathilaka G, Jayathilaka D, Vimalachandran V, Wijewickrama A, Narangoda E, Idampitiya D, Ogg GS, Malavige GN. Similarities and differences between the ‘cytokine storms’ in acute dengue and COVID-19. Sci Rep. 2020;10(1):19839.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duyen HT, Ngoc TV, Ha do T, Hang VT, Kieu NT, Young PR, Farrar JJ, Simmons CP, Wolbers M, Wills BA. Kinetics of plasma viremia and soluble nonstructural protein 1 concentrations in dengue: differential effects according to serotype and immune status. J Infect Dis. 2011;203(9):1292–300.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferrari M, Zevini A, Palermo E, Muscolini M, Alexandridi M, Etna MP, Coccia EM, Fernandez-Sesma A, Coyne C, Zhang DD, Marques ETA, Olagnier D. And Hiscott J. Dengue virus targets Nrf2 for NS2B3-mediated degradation leading to enhanced oxidative stress and viral replication. J Virol. 2020;94:24.

Fonseka CL, Hardman CS, Woo J, Singh R, Nahler J, Yang J, Chen YL, Kamaladasa A, Silva T, Salimi M, Gray N, Dong T, Malavige GN, Ogg GS. Dengue virus co-opts innate type 2 pathways to escape early control of viral replication. Commun Biol. 2022;5(1):735.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghita L, Yao Z, Xie Y, Duran V, Cagirici HB, Samir J, Osman I, Rebellon-Sanchez DE, Agudelo-Rojas OL, Sanz AM, Sahoo MK, Robinson ML, Gelvez-Ramirez RM, Bueno N, Luciani F, Pinsky BA, Montoya JG, Estupinan-Cardenas MI, Villar-Centeno LA, Rojas-Garrido EM, Rosso F, Quake SR, Zanini F, Einav S. Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach. Nat Immunol. 2023;24(12):2150–63.

Article  CAS  PubMed  Google Scholar 

Jang GY, Kim YS, Lee SE, Lee JW, Han HD, Kang TH, Park YM. Improvement of DC-based vaccines using adjuvant TLR4-binding 60S acidic ribosomal protein P2 and immune checkpoint inhibitors. Cancer Immunol Immunotherapy: CII. 2021;70(4):1075–88.

Article  CAS  PubMed  Google Scholar 

Jayathilaka D, Gomes L, Jeewandara C, Jayarathna GSB, Herath D, Perera PA, Fernando S, Wijewickrama A, Hardman CS, Ogg GS, Malavige GN. Role of NS1 antibodies in the pathogenesis of acute secondary dengue infection. Nat Commun. 2018;9(1):5242.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeewandara C, Gomes L, Wickramasinghe N, Gutowska-Owsiak D, Waithe D, Paranavitane SA, Shyamali NL, Ogg GS, Malavige GN. Platelet activating factor contributes to vascular leak in acute dengue infection. PLoS Negl Trop Dis. 2015;9(2):e0003459.

Article  PubMed  PubMed Central  Google Scholar 

Jeewandara C, Gomes L, Udari S, Paranavitane SA, Shyamali NL, Ogg GS, Malavige G. N. Secretory phospholipase A2 in the pathogenesis of acute dengue infection. Immun Inflamm Dis. 2017;5(1):7–15.

Article  CAS  PubMed  Google Scholar 

Kamaladasa A, Gomes L, Jeewandara C, Shyamali NL, Ogg GS, Malavige G. N. Lipopolysaccharide acts synergistically with the dengue virus to induce monocyte production of platelet activating factor and other inflammatory mediators. Antiviral Res. 2016;133:183–90.

Article  CAS  PubMed  Google Scholar 

Kamaladasa A, Gomes L, Wijesinghe A, Jeewandara C, Toh YX, Jayathilaka D, Ogg GS, Fink K. And Malavige G.N. altered monocyte response to the dengue virus in those with varying severity of past dengue infection. Antiviral Res. 2019;169:104554.

Article  CAS  PubMed  Google Scholar 

Khan RA, Afroz S, Minhas G, Battu S, Khan N. Dengue virus envelope protein domain III induces pro-inflammatory signature and triggers activation of inflammasome. Cytokine. 2019;123:154780.

Article  CAS  PubMed  Google Scholar 

Lee PX, Ting DHR, Boey CPH, Tan ETX, Chia JZH, Idris F, Oo Y, Ong LC, Chua YL, Hapuarachchi C, Ng LC, Alonso S. Relative contribution of nonstructural protein 1 in dengue pathogenesis. J Exp Med. 2020;217(9).

Libraty DH, Young PR, Pickering D, Endy TP, Kalayanarooj S, Green S, Vaughn DW, Nisalak A, Ennis FA, Rothman AL. High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. J Infect Dis. 2002;186(8):1165–8.

Article  CAS  PubMed  Google Scholar 

Malavige GN, Ogg GS. Molecular mechanisms in the pathogenesis of dengue infections. Trends Mol Med. 2024.

留言 (0)

沒有登入
gif