Matts P, Oblong J, Bissett DL. A Review of the range of effects of niacinamide in human skin. Int Fed Soc Cosmet Chem Mag. 2002;5:285–9.

Google Scholar 

Boo YC. Mechanistic basis and clinical evidence for the applications of nicotinamide (niacinamide) to control skin aging and pigmentation. Antioxidants. 2021;10(8):1315. https://doi.org/10.3390/antiox10081315.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bissett DL, Miyamoto K, Sun P, Li J, Berge CA. Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin1. Int J Cosmet Sci. 2004;26(5):231–8. https://doi.org/10.1111/j.1467-2494.2004.00228.x.

Article  CAS  PubMed  Google Scholar 

Bissett DL, Oblong JE, Berge CA. Niacinamide: a B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005;31(7 Pt 2):860–5; discussion 5. https://doi.org/10.1111/j.1524-4725.2005.31732.

Article  CAS  PubMed  Google Scholar 

Castanedo-Cazares JP, Lárraga-Piñones G, Ehnis-Pérez A, Fuentes-Ahumada C, Oros-Ovalle C, Smoller BR, Torres-Álvarez B. Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Clin Cosmet Investig Dermatol. 2013;6:29–36. https://doi.org/10.2147/CCID.S39246.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greatens A, Hakozaki T, Koshoffer A, Epstein H, Schwemberger S, Babcock G, Bissett D, Takiwaki H, Arase S, Wickett RR, Boissy RE. Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible. Exp Dermatol. 2005;14(7):498–508. https://doi.org/10.1111/j.0906-6705.2005.00309.x.

Article  CAS  PubMed  Google Scholar 

Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002;147(1):20–31. https://doi.org/10.1046/j.1365-2133.2002.04834.x.

Article  CAS  PubMed  Google Scholar 

Jerajani HR, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ. The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial. Indian J Dermatol Venereol Leprol. 2010;76(1):20–6. https://doi.org/10.4103/0378-6323.58674.

Article  PubMed  Google Scholar 

Kawada A, Konishi N, Oiso N, Kawara S, Date A. Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide. J Dermatol. 2008;35(10):637–42. https://doi.org/10.1111/j.1346-8138.2008.00537.x.

Article  CAS  PubMed  Google Scholar 

Lee DH, Oh IY, Koo KT, Suk JM, Jung SW, Park JO, Kim BJ, Choi YM. Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial. Skin Research and Technology. 2014;20(2):208–12. https://doi.org/10.1111/srt.12107.

Article  PubMed  Google Scholar 

Shariff R, Du Y, Dutta M, Kumar ST, Thimmaiah S, Doraiswamy C, Kumari A, Kale V, Nair N, Zhang S, Joshi M, Santhanam U, Qiang Q, Damodaran A. Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide. Int J Cosmet Sci. 2022;44(1):103–17. https://doi.org/10.1111/ics.12759.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nisbet S, Mahalingam H, Gfeller CF, Biggs E, Lucas S, Thompson M, Cargill MR, Moore D, Bielfeldt S. Cosmetic benefit of a biomimetic lamellar cream formulation on barrier function or the appearance of fine lines and wrinkles in randomized proof-of-concept clinical studies. Int J Cosmet Sci. 2019;41(1):1–11. https://doi.org/10.1111/ics.12499.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu JR, Wang J, Wang SS. A single-center, randomized, controlled study on the efficacy of niacinamide-containing body emollients combined with cleansing gel in the treatment of mild atopic dermatitis. Skin Res Technol. 2023;29(9):e13475. https://doi.org/10.1111/srt.13475.

Article  PubMed  PubMed Central  Google Scholar 

Khodaeiani E, Fouladi RF, Amirnia M, Saeidi M, Karimi ER. Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris. Int J Dermatol. 2013;52(8):999–1004. https://doi.org/10.1111/ijd.12002.

Article  CAS  PubMed  Google Scholar 

Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol. 1995;34(6):434–7. https://doi.org/10.1111/j.1365-4362.1995.tb04449.x.

Article  CAS  PubMed  Google Scholar 

Cosmetic Ingredient Review Expert Panel. Final report of the safety assessment of niacinamide and niacin. Int J Toxicol. 2005;24(5_suppl):1–31. https://doi.org/10.1080/10915810500434183.

Article  CAS  Google Scholar 

Zhang Y, Lane ME, Hadgraft J, Heinrich M, Chen T, Lian G, Sinko B. A comparison of the in vitro permeation of niacinamide in mammalian skin and in the Parallel Artificial Membrane Permeation Assay (PAMPA) model. Int J Pharm. 2019;556:142–9. https://doi.org/10.1016/j.ijpharm.2018.11.065.

Article  CAS  PubMed  Google Scholar 

Soma Y, Kashima M, Imaizumi A, Takahama H, Kawakami T, Mizoguchi M. Moisturizing effects of topical nicotinamide on atopic dry skin. Int J Dermatol. 2005;44(3):197–202. https://doi.org/10.1111/j.1365-4632.2004.02375.x.

Article  CAS  PubMed  Google Scholar 

Fabbrocini G, Cantelli M, Monfrecola G. Topical nicotinamide for seborrheic dermatitis: an open randomized study. J Dermatolog Treat. 2014;25(3):241–5. https://doi.org/10.3109/09546634.2013.814754.

Article  CAS  PubMed  Google Scholar 

Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, Oros-Ovalle C, Fuentes-Ahumada C, González FJ, Martínez-Ramírez JD, Moncada B. A double-blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma. Dermatol Res Pract. 2011;2011:379173. https://doi.org/10.1155/2011/379173.

Article  PubMed  PubMed Central  Google Scholar 

Crocco EI, Veasey JV, Boin MF, Lellis RF, Alves RO. A novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% for treatment of epidermal melasma. Cutis. 2015;96(5):337–42.

PubMed  Google Scholar 

Campuzano-García AE, Torres-Alvarez B, Hernández-Blanco D, Fuentes-Ahumada C, Cortés-García JD, Castanedo-Cázares JP. DNA methyltransferases in malar melasma and their modification by sunscreen in combination with 4% niacinamide, 0.05% retinoic acid, or placebo. Biomed Res Int. 2019;2019:9068314. https://doi.org/10.1155/2019/9068314.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moloney F, Vestergaard M, Radojkovic B, Damian D. Randomized, double-blinded, placebo controlled study to assess the effect of topical 1% nicotinamide on actinic keratoses. Br J Dermatol. 2010;162(5):1138–9. https://doi.org/10.1111/j.1365-2133.2010.09659.x.

Article  CAS  PubMed  Google Scholar 

Mathapathi MS, Mallemalla P, Vora S, Iyer V, Tiwari JK, Chakrabortty A, Majumdar A. Niacinamide leave-on formulation provides long-lasting protection against bacteria in vivo. Exp Dermatol. 2017;26(9):827–9. https://doi.org/10.1111/exd.13285.

Article  CAS  PubMed  Google Scholar 

Damian DL, Patterson CRS, Stapelberg M, Park J, Barnetson RSC, Halliday GM. UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide. J Investig Dermatol. 2008;128(2):447–54. https://doi.org/10.1038/sj.jid.5701058.

Article  CAS  PubMed  Google Scholar 

Sivapirabu G, Yiasemides E, Halliday GM, Park J, Damian DL. Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans. Br J Dermatol. 2009;161(6):1357–64. https://doi.org/10.1111/j.1365-2133.2009.09244.x.

Article  CAS  PubMed  Google Scholar 

Gensler HL. Prevention of photoimmunosuppression and photocarcinogenesis by topical nicotinamide. Nutr Cancer. 1997;29(2):157–62. https://doi.org/10.1080/01635589709514618.

Article  CAS  PubMed