Carter JV, Galbraith NJ, Yang D, Burton JF, Walker SP, Galandiuk S. Blood-Based MicroRNAs as Biomarkers for the Diagnosis of Colorectal Cancer: A Systematic Review and Meta-Analysis. Br J Cancer. 2017;116(6):762–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng Y, Croce CM. The Role of Micrornas in Human Cancer. Signal Transduct Target Ther. 2016;1:15004.

Article  PubMed  PubMed Central  Google Scholar 

Kalogianni DP, Kalligosfyri PM, Kyriakou IK, Christopoulos TK. Advances in MicroRNA Analysis. Anal Bioanal Chem. 2018;410(3):695–713.

Article  CAS  PubMed  Google Scholar 

Flynt AS, Lai EC. Biological Principles of Microrna-Mediated Regulation: Shared Themes Amid Diversity. Nat Rev Genet. 2008;9(11):831–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartel DP. MicroRNAs: Target Recognition and Regulatory Functions. Cell. 2009;136(2):215–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y, et al. Exogenous Plant MIR168a Specifically Targets Mammalian LDLRAP1: Evidence of cRoss-Kingdom Regulation by MicroRNA. Cell Res. 2012;22(1):107–26.

Article  CAS  PubMed  Google Scholar 

Dávalos A, Pinilla L, López de Las Hazas MC, Pinto-Hernández P, Barbé F, Iglesias-Gutiérrez E, et al. Dietary MicroRNAs and Cancer: A New Therapeutic Approach? Semin Cancer Biol. 2021;73:19–29.

Article  PubMed  Google Scholar 

Del Pozo-Acebo L, López de Las Hazas MC, Margollés A, Dávalos A, García-Ruiz A. Eating MicroRNAs: Pharmacological Opportunities for Cross-Kingdom Regulation and Implications in Host Gene and Gut Microbiota Modulation. Br J Pharmacol. 2021;178(11):2218–45.

Article  PubMed  Google Scholar 

Chin AR, Fong MY, Somlo G, Wu J, Swiderski P, Wu X, et al. Cross-kingdom Inhibition of Breast Cancer Growth by Plant MiR159. Cell Res. 2016;26(2):217–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim J, Li S, Zhang S, Wang J. Plant-Derived Exosome-Like Nanoparticles and their Therapeutic Activities. Asian J Pharm Sci. 2022;17(1):53–69.

Article  CAS  PubMed  Google Scholar 

Anusha R, Priya S. Dietary Exosome-Like Nanoparticles: an Updated Review on their Pharmacological and Drug Delivery Applications. Mol Nutr Food Res. 2022;66(14):e2200142.

Article  PubMed  Google Scholar 

Urzì O, Gasparro R, Ganji NR, Alessandro R, Raimondo S. Plant-RNA in Extracellular Vesicles: The Secret of Cross-Kingdom Communication. Membr (Basel). 2022;12(4):352.

Google Scholar 

Record M. Exosome-Like Nanoparticles from Food: Protective Nanoshuttles for Bioactive Cargo. Mol Ther. 2013;21(7):1294–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Halperin W, Jensen WA. Ultrastructural Changes During Growth and Embryogenesis in Carrot Cell Cultures. J Ultrastruct Res. 1967;18(3):428–43.

Article  CAS  PubMed  Google Scholar 

Ju S, Mu J, Dokland T, Zhuang X, Wang Q, Jiang H, et al. Grape Exosome-Like Nanoparticles Induce Intestinal Stem Cells and Protect Mice from DSS-Induced Colitis. Mol Ther. 2013;21(7):1345–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Zhang Y, Dong P, An R, Xue C, Ge Y, et al. Digestion of Nucleic Acids Starts in the Stomach. Sci Rep. 2015;5:11936.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin X, Wang X, Xu K, Zhang Y, Ren X, Qi B, et al. Digestion of Plant Dietary miRNAs Starts in the Mouth Under the Protection of Coingested Food Components and Plant-Derived Exosome-like nanoparticles. J Agric Food Chem. 2022;70(14):4316–27.

Article  CAS  PubMed  Google Scholar 

Wang B, Zhuang X, Deng ZB, Jiang H, Mu J, Wang Q, et al. Targeted Drug Delivery to Intestinal Macrophages by Bioactive Nanovesicles Released from Grapefruit. Mol Ther. 2014;22(3):522–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mu J, Zhuang X, Wang Q, Jiang H, Deng ZB, Wang B, et al. Interspecies Communication between Plant and Mouse Gut Host Cells Through Edible Plant Derived Exosome-Like Nanoparticles. Mol Nutr Food Res. 2014;58(7):1561–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sundaram GM. Dietary Non-Coding RNAs from Plants: Fairy Tale or Treasure? Noncoding RNA Res. 2019;4(2):63–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Link J, Thon C, Schanze D, Steponaitiene R, Kupcinskas J, Zenker M, et al. Food-Derived Xeno-MicroRNAs: Influence of Diet and Detectability in Gastrointestinal Tract-Proof-of-Principle Study. Mol Nutr Food Res. 2019;63(2):e1800076.

Article  PubMed  Google Scholar 

Zhou F, Paz HA, Sadri M, Cui J, Kachman SD, Fernando SC, et al. Dietary Bovine Milk Exosomes Elicit Changes in Bacterial Communities in C57BL/6 mice. Am J Physiol Gastrointest Liver Physiol. 2019;317(5):G618–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, et al. Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells. Mol Pharm. 2018;15(12):5772–80.

Article  CAS  PubMed  Google Scholar 

Komori H, Fujita D, Shirasaki Y, Zhu Q, Iwamoto Y, Nakanishi T, et al. MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion-transporting Peptide 2B1/SLCO2B1 in Caco-2 Cells. Drug Metab Dispos. 2021;49(9):803–9.

Article  CAS  PubMed  Google Scholar 

Zhang M, Xiao B, Wang H, Han MK, Zhang Z, Viennois E, et al. Edible Ginger-Derived Nano-Lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach for Colon cancer Therapy. Mol Ther. 2016;24(10):1783–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Zhang M, Flores SRL, Woloshun RR, Yang C, Yin L, et al. Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis. Mol Ther. 2019;27(3):493–506.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chassaing B, Gewirtz AT. Gut Microbiota, Low-Grade Inflammation, and Metabolic Syndrome. Toxicol Pathol. 2014;42(1):49–53.

Article  PubMed  Google Scholar 

Mei S, Deng Z, Chen Y, Ning D, Guo Y, Fan X, et al. Dysbiosis: The First Hit for Digestive System Cancer. Front Physiol. 2022;13:1040991.

Article  PubMed  PubMed Central  Google Scholar 

Achiwa K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Hayashi K, et al. DSS Colitis Promotes Tumorigenesis and Fibrogenesis in a Choline-Deficient High-Fat Diet-Induced NASH Mouse Model. Biochem Biophys Res Commun. 2016;470(1):15–21.

Article  CAS  PubMed  Google Scholar 

Gritzapis AD, Voutsas IF, Lekka E, Tsavaris N, Missitzis I, Sotiropoulou P, et al. Identification of a Novel Immunogenic HLA-A*0201-Binding Epitope of HER-2/neu with Potent Antitumor Properties. J Immunol. 2008;181(1):146–54.

Article  CAS  PubMed