This study was supported by grants from the Canadian Institutes of Health Research (AWD-022443, PJT-148698, COP-143083, COP-137359) and from the Natural Sciences and Engineering Research Council of Canada (RGPIN-2019-05179, RGPIN-2020-06752, RGPIN-2018-03727). All imaging was performed at the University of British Columbia Life Sciences Institute Imaging Core Facility, RRID:SCR_023783.

Author contributions: Conceptualization: B. Cardoen, K. Vandevoorde, G. Gao, M. Ortiz-Silva, G. Hamarneh, and I.R. Nabi. Data Curation: B. Cardoen, K. Vandevoorde, G. Gao, and M. Ortiz-Silva. Formal Analysis: B. Cardoen, K. Vandevoorde, G. Gao, M. Ortiz-Silva, and P. Alan. Funding Acquisition: G. Hamarneh and I.R. Nabi. Investigation: B. Cardoen, K. Vandevoorde, G. Gao, M. Ortiz-Silva, W. Liu, E. Tiliakou, and A.W. Vogl. Methodology: B. Cardoen, K. Vandevoorde, G. Gao, M. Ortiz-Silva, P. Alan, A.W. Vogl, G. Hamarneh, and I.R. Nabi. Project Administration: G. Hamarneh and I.R. Nabi. Resources: G. Hamarneh and I.R. Nabi. Software: B. Cardoen and G. Hamarneh. Supervision: G. Hamarneh and I.R. Nabi. Validation: B. Cardoen, K. Vandevoorde, G. Gao, M. Ortiz-Silva, P. Alan, A.W. Vogl, G. Hamarneh, and I.R. Nabi. Visualization: B. Cardoen, K. Vandevoorde, G. Gao, M. Ortiz-Silva, W. Liu, A.W. Vogl, G. Hamarneh, and I.R. Nabi. Writing—Original Draft: B. Cardoen, K. Vandevoorde, G. Gao, and I.R. Nabi. Writing—Review & Editing: B. Cardoen, K. Vandevoorde, G. Gao, M. Ortiz-Silva, P. Alan, W. Liu, A.W. Vogl, G. Hamarneh, and I.R. Nabi.