PIK3CA mutation fortifies molecular determinants for immune signaling in vascular cancers

Antonescu C. Malignant vascular tumors-an update. Mod Pathol. 2014;27:S30–38. Suppl 1

Article  CAS  PubMed  Google Scholar 

Wagner MJ, Ravi V, Schaub SK, Kim EY, Sharib J, Mogal H, et al. Incidence and presenting characteristics of angiosarcoma in the US, 2001-2020. JAMA Netw Open. 2024;7:e246235.

Article  PubMed  PubMed Central  Google Scholar 

Vail DM, MacEwen EG. Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Investig. 2000;18:781–92.

Article  CAS  Google Scholar 

Cohen SM, Storer RD, Criswell KA, Doerrer NG, Dellarco VL, Pegg DG, et al. Hemangiosarcoma in rodents: mode-of-action evaluation and human relevance. Toxicol Sci. 2009;111:4–18.

Article  CAS  PubMed  Google Scholar 

Kakiuchi-Kiyota S, Crabbs TA, Arnold LL, Pennington KL, Cook JC, Malarkey DE, et al. Evaluation of expression profiles of hematopoietic stem cell, endothelial cell, and myeloid cell antigens in spontaneous and chemically induced hemangiosarcomas and hemangiomas in mice. Toxicol Pathol. 2013;41:709–21.

Article  CAS  PubMed  Google Scholar 

Liu L, Kakiuchi-Kiyota S, Arnold LL, Johansson SL, Wert D, Cohen SM. Pathogenesis of human hemangiosarcomas and hemangiomas. Hum Pathol. 2013;44:2302–11.

Article  CAS  PubMed  Google Scholar 

Kim JH, Graef AJ, Dickerson EB, Modiano JF. Pathobiology of hemangiosarcoma in dogs: research advances and future perspectives. Vet Sci. 2015;2:388–405.

Article  PubMed  PubMed Central  Google Scholar 

Kakiuchi-Kiyota S, Obert LA, Crowell DM, Xia S, Roy MD, Coskran TM, et al. Expression of hematopoietic stem and endothelial cell markers in canine hemangiosarcoma. Toxicol Pathol. 2020;48:481–93.

Article  CAS  PubMed  Google Scholar 

Buehler D, Rice SR, Moody JS, Rush P, Hafez GR, Attia S, et al. Angiosarcoma outcomes and prognostic factors: a 25-year single institution experience. Am J Clin Oncol. 2014;37:473–9.

Article  PubMed  PubMed Central  Google Scholar 

Mullin C, Clifford CA. Histiocytic sarcoma and hemangiosarcoma update. Vet Clin North Am Small Anim Pr. 2019;49:855–79.

Article  Google Scholar 

Chaikin P, Welihozkiy A. Hemangiosarcoma in a dog: unusual presentation and increased survival using a complementary/holistic approach combined with metronomic chemotherapy. Case Rep Vet Med. 2018;2018:6160980.

PubMed  PubMed Central  Google Scholar 

Kim JH, Schulte AJ, Sarver AL, Lee D, Angelos MG, Frantz AM, et al. Hemangiosarcoma cells promote conserved host-derived hematopoietic expansion. Cancer Res Commun. 2024;4:1467–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang G, Wu M, Maloneyhuss MA, Wojcik J, Durham AC, Mason NJ, et al. Actionable mutations in canine hemangiosarcoma. PLoS One. 2017;12:e0188667.

Article  PubMed  PubMed Central  Google Scholar 

Chan JY, Lim JQ, Yeong J, Ravi V, Guan P, Boot A, et al. Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma. J Clin Investig. 2020;130:5833–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JH, Megquier K, Thomas R, Sarver AL, Song JM, Kim YT, et al. Genomically complex human angiosarcoma and canine hemangiosarcoma establish convergent angiogenic transcriptional programs driven by novel gene fusions. Mol Cancer Res. 2021;19:847–61.

Article  PubMed  PubMed Central  Google Scholar 

Megquier K, Turner-Maier J, Swofford R, Kim JH, Sarver AL, Wang C, et al. Comparative genomics reveals shared mutational landscape in canine hemangiosarcoma and human angiosarcoma. Mol Cancer Res. 2019;17:2410–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Painter CA, Jain E, Tomson BN, Dunphy M, Stoddard RE, Thomas BS, et al. The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research. Nat Med. 2020;26:181–7.

Article  CAS  PubMed  Google Scholar 

Estabrooks T, Gurinovich A, Pietruska J, Lewis B, Harvey G, Post G, et al. Identification of genomic alterations with clinical impact in canine splenic hemangiosarcoma. Vet Comp Oncol. 2023;21:623–33.

Article  CAS  PubMed  Google Scholar 

Wang G, Wu M, Durham AC, Radaelli E, Mason NJ, Xu X, et al. Molecular subtypes in canine hemangiosarcoma reveal similarities with human angiosarcoma. PLoS One. 2020;15:e0229728.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pyuen AA, Meuten T, Rose BJ, Thamm DH. In vitro effects of PI3K/mTOR inhibition in canine hemangiosarcoma. PLoS One. 2018;13:e0200634.

Article  PubMed  PubMed Central  Google Scholar 

Italiano A, Chen CL, Thomas R, Breen M, Bonnet F, Sevenet N, et al. Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics. Cancer. 2012;118:5878–87.

Article  CAS  PubMed  Google Scholar 

Yang J, Nie J, Ma X, Wei Y, Peng Y, Wei X. Targeting PI3K in cancer: mechanisms and advances in clinical trials. Mol Cancer. 2019;18:26.

Article  PubMed  PubMed Central  Google Scholar 

Karar J, Maity A. PI3K/AKT/mTOR pathway in angiogenesis. Front Mol Neurosci. 2011;4:51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akhtar N, Padilla ML, Dickerson EB, Steinberg H, Breen M, Auerbach R, et al. Interleukin-12 inhibits tumor growth in a novel angiogenesis canine hemangiosarcoma xenograft model. Neoplasia. 2004;6:106–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng S, Wang W, Aldahdooh J, Malyutina A, Shadbahr T, Tanoli Z, et al. SynergyFinder Plus: toward better interpretation and annotation of drug combination screening datasets. Genomics Proteom Bioinforma. 2022;20:587–96.

Article  Google Scholar 

Hitz BC, Jin-Wook L, Jolanki O, Kagda MS, Graham K, Sud P, et al. The ENCODE Uniform Analysis Pipelines. bioRxiv 2023. https://doi.org/10.1101/2023.04.04.535623.

Chamberlain CA, Rubio VY, Garrett TJ. Impact of matrix effects and ionization efficiency in non-quantitative untargeted metabolomics. Metabolomics. 2019;15:135.

Article  PubMed  Google Scholar 

Schmid R, Heuckeroth S, Korf A, Smirnov A, Myers O, Dyrlund TS, et al. Integrative analysis of multimodal mass spectrometry data in MZmine 3. Nat Biotechnol. 2023;41:447–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khammanivong A, Saha J, Spartz AK, Sorenson BS, Bush AG, Korpela DM, et al. A novel MCT1 and MCT4 dual inhibitor reduces mitochondrial metabolism and inhibits tumour growth of feline oral squamous cell carcinoma. Vet Comp Oncol. 2020;18:324–41.

Article  CAS  PubMed  Google Scholar 

Kim JH, Frantz AM, Anderson KL, Graef AJ, Scott MC, Robinson S, et al. Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment. Exp Cell Res. 2014;323:155–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wan G, Pehlke C, Pepermans R, Cannon JL, Lidke D, Rajput A. The H1047R point mutation in p110 alpha changes the morphology of human colon HCT116 cancer cells. Cell Death Discov. 2015;1:15044.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang W, Soares J, Greninger P, Edelman EJ

留言 (0)

沒有登入
gif