CEACAM6 facilitates gastric cancer progression through upregulating SLC27A2

Thrift AP, Wenker TN, El-Serag HB. Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention. Nat Rev Clin Oncol. 2023;20:338–49.

Article  PubMed  Google Scholar 

Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74:12–49.

Article  PubMed  Google Scholar 

Yuan SQ, Nie RC, Jin Y, Liang CC, Li YF, Jian R, et al. Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial. Nat Med. 2024;30:552–9.

Tallent A. Zolbetuximab improves survival in gastric cancer. Cancer Discov. 2023;13:520–1.

Alsina M, Arrazubi V, Diez M, Tabernero J. Current developments in gastric cancer: from molecular profiling to treatment strategy. Nat Rev Gastroenterol Hepatol. 2023;20:155–70.

Article  PubMed  Google Scholar 

Le J, Pan G, Zhang C, Chen Y, Tiwari AK, Qin JJ. Targeting ferroptosis in gastric cancer: Strategies and opportunities. Immunol Rev. 2024;321:228–45.

Article  PubMed  Google Scholar 

Lim MCC, Jantaree P, Naumann M. The conundrum of Helicobacter pylori-associated apoptosis in gastric cancer. Trends Cancer. 2023;9:679–90.

Article  PubMed  Google Scholar 

Navashenaq JG, Shabgah AG, Banach M, Jamialahmadi T, Penson PE, Johnston TP, et al. The interaction of Helicobacter pylori with cancer immunomodulatory stromal cells: New insight into gastric cancer pathogenesis. Semin Cancer Biol. 2022;86:951–9.

Article  PubMed  Google Scholar 

Mao X, Ji T, Liu A, Weng Y. ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis. Cell Death Dis. 2021;12:957.

Article  PubMed  PubMed Central  Google Scholar 

Bonsor DA, Gunther S, Beadenkopf R, Beckett D, Sundberg EJ. Diverse oligomeric states of CEACAM IgV domains. Proc Natl Acad Sci USA. 2015;112:13561–6.

Article  PubMed  PubMed Central  Google Scholar 

Chu YD, Cheng LC, Lim SN, Lai MW, Yeh CT, Lin WR. Aldolase B-driven lactagenesis and CEACAM6 activation promote cell renewal and chemoresistance in colorectal cancer through the Warburg effect. Cell Death Dis. 2023;14:660.

Article  PubMed  PubMed Central  Google Scholar 

Litkouhi B, Litkouhi B, Fleming E, Welch WR, Berkowitz RS, Birrer MJ, et al. Overexpression of CEACAM6 in borderline and invasive mucinous ovarian neoplasms. Gynecol Oncol. 2008;109:234–9.

Article  PubMed  Google Scholar 

Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW, Whang EE. A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. Cancer Res. 2004;64:3987–93.

Article  PubMed  Google Scholar 

Poy MN, Ruch RJ, Fernstrom MA, Okabayashi Y, Najjar SM. Shc and CEACAM1 interact to regulate the mitogenic action of insulin. J Biol Chem. 2002;277:1076–84.

Article  PubMed  Google Scholar 

Hu Y, Smyth GK. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J Immunol Methods. 2009;347:70–78.

Article  PubMed  Google Scholar 

Vasaikar SV, Straub P, Wang J, Zhang B. LinkedOmics: analyzing multi-omics data within and across 32 cancer types. Nucleic Acids Res. 2018;46:D956–D963.

Article  PubMed  Google Scholar 

Sun Q, Guven B, Wagg CS, de Oliveira AA, Silver H, Zhang L, et al. Mitochondrial fatty acid oxidation is the major source of cardiac ATP production in heart failure with preserved ejection fraction. Cardiovasc Res. 2024;120(4):360–371.

Samovski D, Jacome-Sosa M, Abumrad NA. Fatty acid transport and signaling: mechanisms and physiological implications. Annu Rev Physiol. 2023;85:317–37.

Article  PubMed  Google Scholar 

Spano D, Catara G. Targeting the Ubiquitin-Proteasome system and recent advances in cancer therapy. Cells. 2023;13:29.

Article  PubMed  PubMed Central  Google Scholar 

Osei-Amponsa V, Walters KJ. Proteasome substrate receptors and their therapeutic potential. Trends Biochem Sci. 2022;47:950–64.

Article  PubMed  PubMed Central  Google Scholar 

Veglia F, Tyurin VA, Blasi M, De Leo A, Kossenkov AV, Donthireddy L, et al. Fatty acid transport protein 2 reprograms neutrophils in cancer. Nature. 2019;569:73–78.

Article  PubMed  PubMed Central  Google Scholar 

Zang M, Zhang Y, Zhang B, Hu L, Li J, Fan Z, et al. CEACAM6 promotes tumor angiogenesis and vasculogenic mimicry in gastric cancer via FAK signaling. Biochim Biophys Acta. 2015;1852:1020–8.

Article  PubMed  Google Scholar 

Zang M, Zhang B, Zhang Y, Li J, Su L, Zhu Z, et al. CEACAM6 promotes gastric cancer invasion and metastasis by inducing epithelial-mesenchymal transition via PI3K/AKT signaling pathway. PLoS ONE. 2014;9:e112908.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Y, Zang M, Li J, Ji J, Zhang J, Liu X, et al. CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer. Acta Biochim Biophys Sin. 2014;46:283–90.

Article  PubMed  Google Scholar 

Roy RK, Hoppe MM, Srivastava S, Samanta A, Sharma N, Tan KT, et al. CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer. Oncotarget. 2016;7:55290–301.

Article  PubMed  PubMed Central  Google Scholar 

Koundouros N, Poulogiannis G. Reprogramming of fatty acid metabolism in cancer. Br J Cancer. 2020;122:4–22.

Article  PubMed  Google Scholar 

Jin Z, Chai YD, Hu S. Fatty acid metabolism and cancer. Adv Exp Med Biol. 2021;1280:231–41.

Article  PubMed  Google Scholar 

Lim GB. Inhibiting fatty acid oxidation promotes cardiomyocyte proliferation. Nat Rev Cardiol. 2020;17:266–7.

Article  PubMed  Google Scholar 

Vogel FCE, Chaves-Filho AB, Schulze A. Lipids as mediators of cancer progression and metastasis. Nat Cancer. 2024;5:16–29.

Tao L, Mohammad MA, Milazzo G, Moreno-Smith M, Patel TD, Zorman B, et al. MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma. Nat Commun. 2022;13:3728.

Article  PubMed  PubMed Central  Google Scholar 

Black PN, Ahowesso C, Montefusco D, Saini N, DiRusso CC. Fatty acid transport proteins: targeting FATP2 as a gatekeeper involved in the transport of exogenous fatty acids. Medchemcomm. 2016;7:612–22.

Article  PubMed  Google Scholar 

Chen Y, Yan Q, Lv M, Song K, Dai Y, Huang Y, et al. Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis. Cell Death Dis. 2020;11:994.

Article  PubMed  PubMed Central  Google Scholar 

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