Reversible downregulation of MYC in a spheroid model of metastatic epithelial ovarian cancer

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA: A Cancer J Clinicians. 2023;73:17–48.

Google Scholar 

Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, et al. Ovarian cancer statistics, 2018. CA: A Cancer J Clinicians. 2018;68:284–96.

Google Scholar 

Gurung A, Hung T, Morin J, Gilks CB. Molecular abnormalities in ovarian carcinoma: clinical, morphological and therapeutic correlates. Histopathology. 2013;62:59–70.

Article  PubMed  Google Scholar 

Miki Y, Swensen J, Shattuck-Eidens J, Futreal PA, Harshman K, Tavtigian S, et al. A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1. Science. 1994;266:66–71.

Article  CAS  PubMed  Google Scholar 

Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, et al. Identification of the breast cancer susceptibility gene BRCA2. Nature. 1995;378:789–92.

Article  CAS  PubMed  Google Scholar 

Kuchenbaecker KB, Hopper JL, Barnes DR, Phillips K-A, Mooij TM, Roos-Blom M-J, et al. Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers. JAMA. 2017;317:2402–16.

Article  CAS  PubMed  Google Scholar 

Zheng G, Yu H, Kanerva A, Forsti A, Sundquist K, Hemminki K. Familial risks of ovarian cancer by age at diagnosis, proband type and histology. PLOS ONE. 2018;13:e0205000.

Article  PubMed  PubMed Central  Google Scholar 

Collaborative Group On Epidemiological Studies Of Ovarian Cancer. Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies. Lancet. 2015;385:1835–42.

Article  PubMed Central  Google Scholar 

Britt K, Short R. The plight of nuns: hazards of nulliparity. Lancet. 2012;379:2322–3.

Article  PubMed  Google Scholar 

Ahmed N, Stenvers KL. Getting to know ovarian cancer ascites: opportunities for targeted therapy-based translational research. Front Oncol. 2013;3:256.

Article  PubMed  PubMed Central  Google Scholar 

Kipps E, Tan DS, Kaye SB. Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research. Nat Rev Cancer. 2013;13:273–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ayantunde AA, Parsons SL. Pattern and prognostic factors in patients with malignant ascites: a retrospective study. Ann Oncol. 2007;18:945–9.

Article  CAS  PubMed  Google Scholar 

Sheid B. Angiogenic effects of macrophages isolated from ascitic fluid aspirated from women with advanced ovarian cancer. Cancer Lett. 1992;62:153–8.

Article  CAS  PubMed  Google Scholar 

Izar B, Tirosh I, Stover EH, Wakiro I, Cuoco MS, Alter I, et al. A single-cell landscape of high-grade serous ovarian cancer. Nat Med. 2020;26:1271–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Wang W, Wang D, Zhang L, Wang X, He J, et al. Single-Cell Sequencing of Malignant Ascites Reveals Transcriptomic Remodeling of the Tumor Microenvironment during the Progression of Epithelial Ovarian Cancer. Genes. 2022;13:2276.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burleson KM, Casey RC, Skubitz KM, Pambuccian SE, Oegema TR Jr., Skubitz APN. Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers. Gynecologic Oncol. 2004;93:170–81.

Article  CAS  Google Scholar 

Burleson KM, Boente MP, Pambuccian SE, Skubitz AP. Disaggregation and invasion of ovarian carcinoma ascites spheroids. J Transl Med. 2006;4:1–16.

Article  Google Scholar 

Iwanicki MP, Davidowitz RA, Rosa Ng M, Besser A, Muranen T, Merritt M, et al. Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov. 2011;1:144–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Musrap N, Tuccitto A, Karagiannis GS, Saraon P, Batruch I, Diamandis EP. Comparative Proteomics of Ovarian Cancer Aggregate Formation Reveals an Increased Expression of Calcium-activated Chloride Channel Regulator 1 (CLCA1). J Biol Chem. 2015;290:17218–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paullin T, Powell C, Menzie C, Hill R, Cheng F, Martyniuk CJ, et al. Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses. PloS one. 2017;12:e0182930.

Article  PubMed  PubMed Central  Google Scholar 

Parashar D, Nair B, Geethadevi A, George J, Nair A, Tsaih S-W, et al. Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling. Cancer Res. 2020;80:5554–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Correa RJ, Peart T, Valdes YR, DiMattia GE, Shepherd TG. Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids. Carcinogenesis. 2012;33:49–58.

Article  CAS  PubMed  Google Scholar 

Carduner L, Picot CR, Leroy-Dudal J, Blay L, Kellouche S, Carreiras F. Cell cycle arrest or survival signaling through αv integrins, activation of PKC and ERK1/2 lead to anoikis resistance of ovarian cancer spheroids. Exp Cell Res. 2014;320:329–42.

Article  CAS  PubMed  Google Scholar 

Ford CE, Werner B, Hacker NF, Warton K. The untapped potential of ascites in ovarian cancer research and treatment. Br J Cancer. 2020;123:9–16.

Article  PubMed  PubMed Central  Google Scholar 

Chen H, Liu H, Qing G. Targeting oncogenic Myc as a strategy for cancer treatment. Sig Transduct Target Ther. 2018;3:1–7.

Article  Google Scholar 

Zeng M, Kwiatkowski NP, Zhang T, Nabet B, Xu M, Liang Y, et al. Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13. eLife. 2018;7:e39030.

Article  PubMed  PubMed Central  Google Scholar 

Farrell AS, Sears RC. MYC Degradation. Cold Spring Harb Perspect Med. 2014;4:a014365.

Article  PubMed  PubMed Central  Google Scholar 

Dong Y, Tu R, Liu H, Qing G. Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat. Sig Transduct Target Ther. 2020;5:1–11.

Article  Google Scholar 

Buensuceso A, Fritz JL, Collins O, Valdes YR, Borrelli MJ, DiMattia GE, et al. Loss of LKB1-NUAK1 signalling enhances NF-κB activity in a spheroid model of high-grade serous ovarian cancer. Sci Rep. 2022;12:3011.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102:15545–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liberzon A, Berger C, Thorvaldsdottir H, Ghandi M, Mesirov JP, Tamayo P. The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst. 2015;1:417–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng X, Wang X, Cheng X, Liu Z, Yin Y, Li X, et al. Single-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer. Nat Cancer. 2023;4:1138–56.

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif