Zhu AX, Nipp RD, Finn RS, Galle PR, Llovet JM, Blanc JF, et al. Ramucirumab in the second-line for patients with hepatocellular carcinoma and elevated alpha-fetoprotein: patient-reported outcomes across two randomised clinical trials. ESMO Open. 2020;5:e000797.

Article  PubMed  PubMed Central  Google Scholar 

Yang Y, Sun M, Yao W, Wang F, Li X, Wang W, et al. Compound kushen injection relieves tumor-associated macrophage-mediated immunosuppression through TNFR1 and sensitizes hepatocellular carcinoma to sorafenib. J Immunother Cancer. 2020;8:e000317.

Article  PubMed  PubMed Central  Google Scholar 

Ding N, Wang K, Jiang H, Yang M, Zhang L, Fan X, et al. AGK regulates the progression to NASH by affecting mitochondria complex I function. Theranostics. 2022;12:3237–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sorin Y, Ikeda K, Kawamura Y, Fujiyama S, Kobayashi M, Hosaka T, et al. Effectiveness of particle radiotherapy in various stages of hepatocellular carcinoma: a pilot study. Liver cancer. 2018;7:323–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Yang G, Han L, Wang R, Gong C, Yuan Y. Sorafenib and triptolide loaded cancer cell-platelet hybrid membrane-camouflaged liquid crystalline lipid nanoparticles for the treatment of hepatocellular carcinoma. J nanobiotechnology. 2021;19:360.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Y, Zheng QC, Xu S, Yuan Y, Cheng X, Jiang S, et al. Theranostic nanodots with aggregation-induced emission characteristic for targeted and image-guided photodynamic therapy of hepatocellular carcinoma. Theranostics. 2019;9:1264–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang H, Woo HY, Lee SK, Han JW, Jang B, Nam HC, et al. A comparative study of sorafenib and metronomic chemotherapy for Barcelona Clinic Liver Cancer-stage C hepatocellular carcinoma with poor liver function. Clin Mol Hepatol. 2017;23:128–37.

Article  PubMed  PubMed Central  Google Scholar 

Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, et al. Hippo deficiency leads to cardiac dysfunction accompanied by cardiomyocyte dedifferentiation during pressure overload. Circulation Res. 2019;124:292–305.

Article  CAS  PubMed  Google Scholar 

Wang L, Lin M, Chu M, Liu Y, Ma J, He Y, et al. SPOP promotes ubiquitination and degradation of LATS1 to enhance kidney cancer progression. EBioMedicine. 2020;56:102795.

Article  PubMed  PubMed Central  Google Scholar 

Xiao Y, Hill MC, Zhang M, Martin TJ, Morikawa Y, Wang S, et al. Hippo signaling plays an essential role in cell state transitions during cardiac fibroblast development. Developmental cell. 2018;45:153–169.e156.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen M, Wu L, Tu J, Zhao Z, Fan X, Mao J, et al. miR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expression. EBioMedicine. 2018;35:142–54.

Article  PubMed  PubMed Central  Google Scholar 

He M, Zhou Z, Shah AA, Hong Y, Chen Q, Wan Y. New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics. Cell Div. 2016;11:4.

Article  PubMed  PubMed Central  Google Scholar 

Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat cell Biol. 2015;17:95–103.

Article  CAS  PubMed  Google Scholar 

Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment JV, et al. Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. Nat cell Biol. 2014;16:1016–26. 1011-1018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, et al. TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling. Nat Commun. 2019;10:2863.

Article  PubMed  PubMed Central  Google Scholar 

Zou H, Chen H, Zhou Z, Wan Y, Liu Z. ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4. Cancer Lett. 2019;467:19–28.

Article  CAS  PubMed  Google Scholar 

Tang J, Luo Y, Xiao L. USP26 promotes anaplastic thyroid cancer progression by stabilizing TAZ. Cell Death Dis. 2022;13:326.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng Y, Ouyang L, Zhou Y, Lai W, Chen Y, Wang Z, et al. AhR Promotes the Development of Non-small cell lung cancer by Inducing SLC7A11-dependent Antioxidant Function. J Cancer. 2023;14:821–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y, Lih TM, Pan J, Höti N, Dong M, Cao L, et al. Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets. J Hematol Oncol. 2020;13:170.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bertino G. Hepatocellular carcinoma: present and future. Chin Clin Oncol. 2012;1:14.

PubMed  Google Scholar 

Zheng YL, Li L, Jia YX, Zhang BZ, Li JC, Zhu YH, et al. LINC01554-mediated glucose metabolism reprogramming suppresses tumorigenicity in hepatocellular carcinoma via downregulating PKM2 expression and inhibiting Akt/mTOR signaling pathway. Theranostics. 2019;9:796–810.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel M, Shariff MI, Ladep NG, Thillainayagam AV, Thomas HC, Khan SA, et al. Hepatocellular carcinoma: diagnostics and screening. J evaluation Clin Pract. 2012;18:335–42.

Article  Google Scholar 

Liu X, Yang W, Petrick JL, Liao LM, Wang W, He N, et al. Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality. Nat Commun. 2021;12:6388.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grumati P, Dikic I. Ubiquitin signaling and autophagy. J Biol Chem. 2018;293:5404–13.

Article  CAS  PubMed  Google Scholar 

Nelson DE, Randle SJ, Laman H. Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins. Open Biol. 2013;3:130131.

Article  PubMed  PubMed Central  Google Scholar 

Çetin G, Klafack S, Studencka-Turski M, Krüger E, Ebstein F. The ubiquitin-proteasome system in immune cells. Biomolecules. 2021;11:60.

Article  PubMed  PubMed Central  Google Scholar 

Malynn BA, Ma A. Ubiquitin makes its mark on immune regulation. Immunity. 2010;33:843–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ting X, Xia L, Yang J, He L, Si W, Shang Y, et al. USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair. Nucleic acids Res. 2019;47:9721–40.

Article  PubMed  PubMed Central  Google Scholar 

Feng X, Jia Y, Zhang Y, Ma F, Zhu Y, Hong X, et al. Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth. Autophagy. 2019;15:1130–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q, Zheng W, Guan J, Liu H, Dan Y, Zhu L, et al. SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma. Cell death Differ. 2023;30:137–51.