Mesenchymal stem cell therapy as a game-changer in liver diseases: review of current clinical trials

Devarbhavi H, Asrani SK, Arab JP, Nartey YA, Pose E. Kamath P.S. global burden of liver disease: 2023 update. J Hepatol. 2023;79(2):516–37.

Article  PubMed  Google Scholar 

Sharma A, Nagalli S. Chronic Liver Disease. StatPearls, Treasure Island (FL) ineligible companies. Disclosure: Shivaraj Nagalli declares no relevant financial relationships with ineligible companies., 2024.

Sriram I, Nicklas D. Biliary atresia. Pediatr Rev. 2022;43(11):659–61.

Article  PubMed  Google Scholar 

Alkhouri N, Gonzalez-Peralta RP, Medici V. Wilson disease: a summary of the updated AASLD practice Guidance. Hepatol Commun. 2023;7(6).

Meng Z, Yang Y. Advances in the treatment of Autoimmune Hepatitis. J Clin Transl Hepatol. 2024;12(10):878–85.

PubMed  PubMed Central  Google Scholar 

Tapper EB, Parikh ND. Diagnosis and management of cirrhosis and its complications: a review. JAMA. 2023;329(18):1589–602.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shingina A. Highlights from the ACG guidelines for Acute Liver failure. Gastroenterol Hepatol (N Y). 2024;20(1):61–3.

PubMed  Google Scholar 

European Association for the Study of the Liver. Electronic address e.e.e., Clinical Practice Guideline Panel, Samuel C, Representative D. E.G.B., Panel m. and European Association for the Study of the L. EASL Clinical Practice Guidelines on liver transplantation. J Hepatol. 2024;81(6):1040–1086.

Issa DH, Alkhouri N. Long-term management of liver transplant recipients: a review for the internist. Cleve Clin J Med. 2015;82(6):361–72.

Article  PubMed  Google Scholar 

Alfaifi M, Eom YW, Newsome PN, Baik SK. Mesenchymal stromal cell therapy for liver diseases. J Hepatol. 2018;68(6):1272–85.

Article  CAS  PubMed  Google Scholar 

Wang LT, Liu KJ, Sytwu HK, Yen ML, Yen BL. Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal stem cells. Stem Cells Transl Med. 2021;10(9):1288–303.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao L, Hu X, Dai K, Yuan M, Liu P, Zhang Q, Jiang Y. Mesenchymal stromal cells: promising treatment for liver cirrhosis. Stem Cell Res Ther. 2022;13(1):308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. J Hepatol. 2019;70(1):151–71.

Article  PubMed  Google Scholar 

Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, Vierling JM, Alsawas M, Murad MH, Czaja AJ. Diagnosis and management of Autoimmune Hepatitis in adults and children: 2019 Practice Guidance and Guidelines from the American Association for the study of Liver diseases. Hepatology. 2020;72(2):671–722.

Article  PubMed  Google Scholar 

Czlonkowska A, Litwin T, Dusek P, Ferenci P, Lutsenko S, Medici V, Rybakowski JK, Weiss KH, Schilsky ML. Wilson disease. Nat Rev Dis Primers. 2018;4(1):21.

Article  PubMed  PubMed Central  Google Scholar 

Schilsky ML. Wilson disease: new insights into pathogenesis, diagnosis, and future therapy. Curr Gastroenterol Rep. 2005;7(1):26–31.

Article  PubMed  Google Scholar 

Hartley JL, Davenport M, Kelly DA. Biliary atresia. Lancet. 2009;374(9702):1704–13.

Article  PubMed  Google Scholar 

Bezerra JA, Wells RG, Mack CL, Karpen SJ, Hoofnagle JH, Doo E, Sokol RJ. Biliary atresia: clinical and Research challenges for the twenty-First Century. Hepatology. 2018;68(3):1163–73.

Article  PubMed  Google Scholar 

Schuppan D, Afdhal NH. Liver cirrhosis. Lancet. 2008;371(9615):838–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet. 2014;383(9930):1749–61.

Article  PubMed  Google Scholar 

Zhang CY, Yuan WG, He P, Lei JH, Wang CX. Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets. World J Gastroenterol. 2016;22(48):10512–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bernal W, Wendon J. Acute liver failure. N Engl J Med. 2013;369(26):2525–34.

Article  CAS  PubMed  Google Scholar 

Stravitz RT, Lee WM. Acute liver failure. Lancet. 2019;394(10201):869–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neuberger JM, Bechstein WO, Kuypers DR, Burra P, Citterio F, De Geest S, Duvoux C, Jardine AG, Kamar N, Kramer BK, Metselaar HJ, Nevens F, Pirenne J, Rodriguez-Peralvarez ML, Samuel D, Schneeberger S, Seron D, Trunecka P, Tisone G, van Gelder T. Practical recommendations for long-term management of modifiable risks in kidney and liver transplant recipients: a Guidance Report and Clinical Checklist by the Consensus on managing modifiable risk in transplantation (COMMIT) Group. Transplantation. 2017;101(4S Suppl 2):S1–56.

Article  PubMed  Google Scholar 

Charlton M, Levitsky J, Aqel B, O’Grady J, Hemibach J, Rinella M, Fung J, Ghabril M, Thomason R, Burra P, Little EC, Berenguer M, Shaked A, Trotter J, Roberts J, Rodriguez-Davalos M, Rela M, Pomfret E, Heyrend C, Gallegos-Orozco J, Saliba F. International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant recipients. Transplantation. 2018;102(5):727–43.

Article  PubMed  Google Scholar 

Kuo A, Terrault NA. Management of hepatitis C in liver transplant recipients. Am J Transpl. 2006;6(3):449–58.

Article  CAS  Google Scholar 

Koyama Y, Brenner DA. Liver inflammation and fibrosis. J Clin Invest. 2017;127(1):55–64.

Article  PubMed  PubMed Central  Google Scholar 

Papaioannou S, See JX, Jeong M, De La Torre C, Ast V, Reiners-Koch PS, Sati A, Mogler C, Platten M, Cerwenka A, Stojanovic A. Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury. Cell Rep. 2023;42(8):112836.

Article  CAS  PubMed  Google Scholar 

Wang LT, Ting CH, Yen ML, Liu KJ, Sytwu HK, Wu KK, Yen BL. Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials. J Biomed Sci. 2016;23(1):76.

Article  PubMed  PubMed Central  Google Scholar 

Kharaziha P, Hellstrom PM, Noorinayer B, Farzaneh F, Aghajani K, Jafari F, Telkabadi M, Atashi A, Honardoost M, Zali MR, Soleimani M. Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial. Eur J Gastroenterol Hepatol. 2009;21(10):1199–205.

Article  CAS  PubMed  Google Scholar 

Shi M, Zhang Z, Xu R, Lin H, Fu J, Zou Z, Zhang A, Shi J, Chen L, Lv S, He W, Geng H, Jin L, Liu Z, Wang FS. Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients. Stem Cells Transl Med. 2012;1(10):725–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu W, Qu J, Yan L, Tang X, Wang X, Ye A, Zou Z, Li L, Ye J, Zhou L. Efficacy and safety of mesenchymal stem cell therapy in liver cirrhosis: a systematic review and meta-analysis. Stem Cell Res Ther. 2023;14(1):301.

Article  PubMed  PubMed Central  Google Scholar 

Liu P, Qian Y, Liu X, Zhu X, Zhang X, Lv Y, Xiang J. Immunomodulatory role of mesenchymal stem cell therapy in liver fibrosis. Front Immunol. 2022;13:1096402.

Article  CAS  PubMed  Google Scholar 

Sioud M, Mobergslien A, Boudabous A, Floisand Y. Mesenchymal stem cell-mediated T cell suppression occurs through secreted galectins. Int J Oncol. 2011;38(2):385–90.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif