We thank Fabiana Fraga, Laure Vogeleisen-Delpech, and all the staff of the EPFL mouse phenotyping unit for their help and assistance with the in vivo experiments.

This project received funding from the EPFL, the European Research Council under the European Union’s Horizon 2020 research and innovation program (ERC-AdG-787702), the Swiss National Science Foundation (SNSF 31003A_179435 and Sinergia CRSII5_202302), a GRL grant of the National Research Foundation of Korea (NRF 2017K1A1A2013124), and a grant of Janssen Pharmaceuticals. G. Benegiamo was supported by grant #2018-422 of the Strategic Focal Area “Personalized Health and Related Technologies” of the ETH Domain. S. Rodríguez-López was supported by European Molecular Biology Organizaation Short-Term and Postdoctoral Fellowships (ASTF-8521 and ALTF 67–2022).

Author contributions: G. Benegiamo: Conceptualization, methodology, formal analysis, investigation, data curation, writing—original draft, writing–review & editing, project administration. G.V.G. von Alvensleben: Software, formal analysis, writing—original draft. S. Rodríguez-López: Methodology, investigation, writing—review & editing. L.J.E. Goeminne: Formal analysis, writing—review & editing. A.M. Bachmann: Formal analysis, writing—review & editing. J.D. Morel: Formal analysis, writing—review & editing. E. Broeckx: Methodology, investigation, writing—review & editing. J.Y. Ma: Methodology, investigation, writing—review & editing. V. Carreira: Methodology, investigation, writing—review & editing. S.A. Youssef: Methodology, investigation, writing—review & editing. N. Azhar: Formal analysis, data curation, writing - review & editing. D.F. Reilly: Conceptualization, writing - review & editing. K. D’Aquino: Conceptualization, writing—review & editing. S. Mullican: Conceptualization, writing—review & editing. M. Bou-Sleiman: Conceptualization, formal analysis, data curation, writing—review & editing, supervision. J. Auwerx: Conceptualization, resources, writing—original draft, writing—review & editing, supervision, funding acquisition.