Li X, Liu L, Li T, Liu M, Wang Y, Ma H, et al. SIRT6 in Senescence and Aging-Related Cardiovascular Diseases. Front Cell Dev Biol. 2021;9:641315.

Article  PubMed  PubMed Central  Google Scholar 

Li T, Providencia R, Mu N, Yin Y, Chen M, Wang Y, et al. Association of metformin monotherapy or combined therapy with cardiovascular risks in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2021;20(1):30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li T, Mu N, Yin Y, Yu L, Ma H. Targeting AMP-activated protein kinase in aging-related cardiovascular diseases. Aging Dis. 2020;11(4):967–77.

Article  PubMed  PubMed Central  Google Scholar 

Chaligne C, Mageau A, Ducrocq G, Ou P, Alexandra JF, Mutuon P, et al. Acute myocarditis revealing autoimmune and inflammatory disorders: Clinical presentation and outcome. Int J Cardiol. 2022;351:84–8.

Article  PubMed  Google Scholar 

Cheng CY, Baritussio A, Giordani AS, Iliceto S, Marcolongo R, Caforio ALP. Myocarditis in systemic immune-mediated diseases: Prevalence, characteristics and prognosis. A systematic review Autoimmun Rev. 2022;21(4):103037.

Article  CAS  PubMed  Google Scholar 

Zhang J, Yang Y, Yang Z, Li T, Chen F. Snapshot: targeting macrophages as a candidate for tissue regeneration. Curr Issues Mol Biol. 2018;29:37–48.

Article  PubMed  Google Scholar 

Yunna C, Mengru H, Lei W, Weidong C. Macrophage M1/M2 polarization. Eur J Pharmacol. 2020;877:173090.

Article  PubMed  Google Scholar 

Chen M, Menon MC, Wang W, Fu J, Yi Z, Sun Z, et al. HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy. Nat Commun. 2023;14(1):4297.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiong Y, Zhang Z, Liu S, Shen L, Zheng L, Ding L, et al. Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway. Phytomedicine. 2024;123:155193.

Article  CAS  PubMed  Google Scholar 

Adebayo M, Singh S, Singh AP, Dasgupta S. Mitochondrial fusion and fission: the fine-tune balance for cellular homeostasis. FASEB J. 2021;35(6):e21620.

Article  CAS  PubMed  Google Scholar 

Lewis TL Jr, Kwon SK, Lee A, Shaw R, Polleux F. MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size. Nat Commun. 2018;9(1):5008.

Article  PubMed  PubMed Central  Google Scholar 

Rovira-Llopis S, Bañuls C, Diaz-Morales N, Hernandez-Mijares A, Rocha M, Victor VM. Mitochondrial dynamics in type 2 diabetes: pathophysiological implications. Redox Biol. 2017;11:637–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kleele T, Rey T, Winter J, Zaganelli S, Mahecic D, Perreten Lambert H, et al. Distinct fission signatures predict mitochondrial degradation or biogenesis. Nature. 2021;593(7859):435–9.

Article  CAS  PubMed  Google Scholar 

Chen W, Zhao H, Li Y. Mitochondrial dynamics in health and disease: mechanisms and potential targets. Signal Transduct Target Ther. 2023;8(1):333.

Article  PubMed  PubMed Central  Google Scholar 

Quiles JM, Gustafsson ÅB. The role of mitochondrial fission in cardiovascular health and disease. Nat Rev Cardiol. 2022;19(11):723–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie C, Wang FY, Sang Y, Chen B, Huang JH, He FJ, et al. Mitochondrial micropeptide STMP1 enhances mitochondrial fission to promote tumor metastasis. Cancer Res. 2022;82(13):2431–43.

Article  CAS  PubMed  Google Scholar 

Doke T, Susztak K. The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development. Trends Cell Biol. 2022;32(10):841–53.

Article  PubMed  PubMed Central  Google Scholar 

Lin L, Zhang M, Yan R, Shan H, Diao J, Wei J. Inhibition of Drp1 attenuates mitochondrial damage and myocardial injury in Coxsackievirus B3 induced myocarditis. Biochem Biophys Res Commun. 2017;484(3):550–6.

Article  CAS  PubMed  Google Scholar 

Feng J, Yang Y, Zhou Y, Wang B, Xiong H, Fan C, et al. Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1. Apoptosis. 2016;21(5):532–45.

Article  CAS  PubMed  Google Scholar 

Tian X, Huang Y, Zhang X, Fang R, Feng Y, Zhang W, et al. Salidroside attenuates myocardial ischemia/reperfusion injury via AMPK-induced suppression of endoplasmic reticulum stress and mitochondrial fission. Toxicol Appl Pharmacol. 2022;448:116093.

Article  CAS  PubMed  Google Scholar 

Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, et al. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature. 2018;558(7710):401–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeng X, Zhang YD, Ma RY, Chen YJ, Xiang XM, Hou DY, et al. Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis. Mil Med Res. 2022;9(1):25.

CAS  PubMed  PubMed Central  Google Scholar 

Sbai O, Bazzani V, Tapaswi S, McHale J, Vascotto C, Perrone L. Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer’s disease? Front Mol Neurosci. 2023;16:1166879.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma X, Chen A, Melo L, Clemente-Sanchez A, Chao X, Ahmadi AR, et al. Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation. Hepatology. 2023;77(1):159–75.

PubMed  Google Scholar 

Gajić D, Despotović S, Koprivica I, Miljković Đ, Saksida T. Ethyl pyruvate ameliorates experimental autoimmune myocarditis. Biomolecules. 2021;11(12):1768.

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Yang C, Zou M, Wang D, Sheng R, Zhan M, et al. Inhibiting mitochondrial inflammation through Drp1/HK1/NLRP3 pathway: a mechanism of alpinetin attenuated aging-associated cognitive impairment. Phytother Res. 2023;37(6):2454–71.

Article  CAS  PubMed  Google Scholar 

Li S, Tajiri K, Murakoshi N, Xu D, Yonebayashi S, Okabe Y, et al. Programmed Death-Ligand 2 deficiency exacerbates experimental autoimmune myocarditis in mice. Int J Mol Sci. 2021;22(3):246.

Article  CAS  Google Scholar 

Hua X, Hu G, Hu Q, Chang Y, Hu Y, Gao L, et al. Single-Cell RNA sequencing to dissect the immunological network of autoimmune myocarditis. Circulation. 2020;142(4):384–400.

Article  CAS  PubMed  Google Scholar 

Sheng W, Yu J, Zhang H, Zhang J. Empagliflozin attenuates inflammation levels in autoimmune myocarditis through the STAT3 pathway and macrophage phenotype transformation. Mol Immunol. 2024;167:43–52.

Article  CAS  PubMed  Google Scholar 

Gao S, Zhou J, Liu N, Wang L, Gao Q, Wu Y, et al. Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13. J Mol Cell Cardiol. 2015;85:131–9.

Article  CAS  PubMed  Google Scholar 

Yu W, Wang X, Zhao J, Liu R, Liu J, Wang Z, et al. Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages. Redox Biol. 2020;37:101761.

Article