World Health Organization. Leishmaniasis. 2022; Available from: https://www.who.int/health-topics/leishmaniasis#tab=tab_1.

Burza, S., Croft, S. L. & Boelaert, M. Leishmaniasis. Lancet 392, 951–970 (2018).

Article  PubMed  Google Scholar 

Volpedo, G., et al. The history of live attenuated centrin gene-deleted leishmania vaccine candidates. Pathogens, 11. https://doi.org/10.3390/pathogens11040431 (2022).

Zhang, W. W. et al. A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing. Nat. Commun. 11, 3461 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karmakar, S. et al. Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis. Commun. Biol. 4, 929 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan, N. & Chen, Z. J. Intrinsic antiviral immunity. Nat. Immunol. 13, 214–222 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

McNab, F. et al. Type I interferons in infectious disease. Nat. Rev. Immunol. 15, 87–103 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jefferies, C. A. Regulating IRFs in IFN driven disease. Front Immunol. 10, 325 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santini, S. M. et al. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice. J. Exp. Med. 191, 1777–1788 (2000).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santodonato, L. et al. Monocyte-derived dendritic cells generated after a short-term culture with IFN-alpha and granulocyte-macrophage colony-stimulating factor stimulate a potent Epstein-Barr virus-specific CD8+ T cell response. J. Immunol. 170, 5195–5202 (2003).

Article  CAS  PubMed  Google Scholar 

Montoya, M. et al. Type I interferons produced by dendritic cells promote their phenotypic and functional activation. Blood 99, 3263–3271 (2002).

Article  CAS  PubMed  Google Scholar 

Spadaro, F. et al. IFN-alpha enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing. Blood 119, 1407–1417 (2012).

Article  CAS  PubMed  Google Scholar 

Lohoff, M. & Mak, T. W. Roles of interferon-regulatory factors in T-helper-cell differentiation. Nat. Rev. Immunol. 5, 125–135 (2005).

Article  CAS  PubMed  Google Scholar 

Wang, B. X. & Fish, E. N. The yin and yang of viruses and interferons. Trends Immunol. 33, 190–197 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Haque, A. et al. Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity. J. Clin. Invest 124, 2483–2496 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haque, A. et al. Type I interferons suppress CD4(+) T-cell-dependent parasite control during blood-stage Plasmodium infection. Eur. J. Immunol. 41, 2688–2698 (2011).

Article  CAS  PubMed  Google Scholar 

Tan, R. S. et al. Altered immune response of interferon regulatory factor 1-deficient mice against Plasmodium berghei blood-stage malaria infection. Infect. Immun. 67, 2277–2283 (1999).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diefenbach, A. et al. Type 1 interferon (IFNalpha/beta) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity 8, 77–87 (1998).

Article  CAS  PubMed  Google Scholar 

Jaramillo, M. et al. Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell Host Microbe 9, 331–341 (2011).

Article  CAS  PubMed  Google Scholar 

Beiting, D. P. Protozoan parasites and type I interferons: a cold case reopened. Trends Parasitol. 30, 491–498 (2014).

Article  CAS  PubMed  Google Scholar 

Khouri, R. et al. IFN-beta impairs superoxide-dependent parasite killing in human macrophages: evidence for a deleterious role of SOD1 in cutaneous leishmaniasis. J. Immunol. 182, 2525–2531 (2009).

Article  CAS  PubMed  Google Scholar 

Smelt, S. C. et al. B cell-deficient mice are highly resistant to Leishmania donovani infection, but develop neutrophil-mediated tissue pathology. J. Immunol. 164, 3681–3688 (2000).

Article  CAS  PubMed  Google Scholar 

Silva-Barrios, S. et al. Innate immune B cell activation by leishmania donovani exacerbates disease and mediates hypergammaglobulinemia. Cell Rep. 15, 2427–2437 (2016).

Article  CAS  PubMed  Google Scholar 

Silva-Barrios, S. & Stager, S. Protozoan parasites and type I IFNs. Front Immunol. 8, 14 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Silva-Barrios, S. & Stager, S. Hypergammaglobulinemia sustains the development of regulatory responses during chronic Leishmania donovani infection in mice. Eur. J. Immunol. 49, 1082–1091 (2019).

Article  CAS  PubMed  Google Scholar 

Kumar, R. et al. Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis. Cell Rep. 30, 2512–2525.e9 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Teijaro, J. R. et al. Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science 340, 207–211 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mattner, J. et al. Protection against progressive leishmaniasis by IFN-b. J. Immunol. 172, 7574–7582 (2004).

Article  CAS  PubMed  Google Scholar 

Paun, A. et al. Critical role of IRF-5 in the development of T helper 1 responses to Leishmania donovani infection. PLoS Pathog. 7, e1001246 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Honda, K. et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434, 772–777 (2005).

Article  CAS  PubMed  Google Scholar 

Honda, K. & Taniguchi, T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6, 644–658 (2006).

Article  CAS  PubMed  Google Scholar 

Favila, M. A. et al. Differential impact of LPG-and PG-deficient leishmania major mutants on the immune response of human dendritic cells. PLoS Negl. Trop. Dis. 9, e0004238 (2015).

Article  PubMed  PubMed Central