Page, R. L. et al. Medical marijuana, recreational cannabis, and cardiovascular health: a scientific statement from the American Heart Association. Circulation 142, e131–e152 (2020).

Article  PubMed  Google Scholar 

Chandy, M. et al. Adverse impact of cannabis on human health. Annu. Rev. Med. 75, 353–367 (2024).

Article  PubMed  CAS  Google Scholar 

Bridgeman, M. B. & Abazia, D. T. Medicinal cannabis: history, pharmacology, and implications for the acute care setting. P T 42, 180–188 (2017).

PubMed  PubMed Central  Google Scholar 

Ryan, J. E., McCabe, S. E. & Boyd, C. J. Medicinal cannabis: policy, patients, and providers. Policy Polit. Nurs. Pract. 22, 126–133 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Hoffman, A. F. & Lupica, C. R. Synaptic targets of Δ9-tetrahydrocannabinol in the central nervous system. Cold Spring Harb. Perspect. Med. 3, a012237 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Krishna Kumar, K. et al. Structure of a signaling cannabinoid receptor 1-G protein complex. Cell 176, 448–458.e12 (2019).

Article  PubMed  CAS  Google Scholar 

Sugamura, K. et al. Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages. Circulation 119, 28–36 (2009).

Article  PubMed  CAS  Google Scholar 

Netherland, C. D., Pickle, T. G., Bales, A. & Thewke, D. P. Cannabinoid receptor type 2 (CB2) deficiency alters atherosclerotic lesion formation in hyperlipidemic Ldlr-null mice. Atherosclerosis 213, 102–108 (2010).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hoyer, F. F. et al. Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo. J. Mol. Cell Cardiol. 51, 1007–1014 (2011).

Article  PubMed  CAS  Google Scholar 

Pacher, P., Steffens, S., Haskó, G., Schindler, T. H. & Kunos, G. Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly. Nat. Rev. Cardiol. 15, 151–166 (2018).

Article  PubMed  CAS  Google Scholar 

Whiting, P. F. et al. Cannabinoids for medical use: a systematic review and meta-analysis. JAMA 313, 2456–2473 (2015).

Article  PubMed  CAS  Google Scholar 

Bilbao, A. & Spanagel, R. Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications. BMC Med. 20, 259 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Bicket, M. C., Stone, E. M. & McGinty, E. E. Use of cannabis and other pain treatments among adults with chronic pain in US states with medical cannabis programs. JAMA Netw. Open. 6, e2249797 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Zehra, A. et al. Cannabis addiction and the brain: a review. J. Neuroimmune Pharmacol. 13, 438–452 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Secades-Villa, R., Garcia-Rodriguez, O., Jin, C. J., Wang, S. & Blanco, C. Probability and predictors of the cannabis gateway effect: a national study. Int. J. Drug. Policy 26, 135–142 (2015).

Article  PubMed  Google Scholar 

Volkow, N. D., Baler, R. D., Compton, W. M. & Weiss, S. R. Adverse health effects of marijuana use. N. Engl. J. Med. 370, 2219–2227 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Wei, T. T. et al. Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation. Cell 185, 1676–1693.e23 (2022).

Article  PubMed  PubMed Central  CAS  Google Scholar 

DeFilippis, E. M. et al. Cocaine and marijuana use among young adults with myocardial infarction. J. Am. Coll. Cardiol. 71, 2540–2551 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Patton, D. V. A history of United States cannabis law. J. Law Health 34, 1–29 (2020).

PubMed  Google Scholar 

Hall, W. et al. Public health implications of legalising the production and sale of cannabis for medicinal and recreational use. Lancet 394, 1580–1590 (2019).

Article  PubMed  Google Scholar 

Mead, A. Legal and regulatory issues governing cannabis and cannabis-derived products in the United States. Front. Plant. Sci. 10, 697 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Lampe, J. R. Legal consequences of rescheduling marijuana. Congressional Research Service crsreports.congress.gov/product/pdf/LSB/LSB11105 (2024).

Shirah, B. H., Ahmed, M. M. & Saleh, R. A. in Medicinal Usage of Cannabis and Cannabinoids (eds Preedy, V. R., Patel, V. B. & Martin, C. R.) Ch. 5, 51–61 (Academic Press, 2023).

Bahji, A. & Stephenson, C. International perspectives on the implications of cannabis legalization: a systematic review & thematic analysis. Int. J. Env. Res. Public. Health 16, 3095 (2019).

Article  Google Scholar 

Rotermann, M. What has changed since cannabis was legalized? Health Rep. 31, 11–20 (2020).

PubMed  Google Scholar 

Martins, S. S. et al. Racial and ethnic differences in cannabis use following legalization in US states with medical cannabis laws. JAMA Netw. Open. 4, e2127002 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Chemtob, D. Forbes Daily: The Budding $28B Hemp Market’s Feud with Marijuana. Forbes www.forbes.com/sites/daniellechemtob/2024/04/19/forbes-daily-the-budding-28b-hemp-markets-feud-with-marijuana/ (2024).

Fischer, B., Jutras-Aswad, D. & Hall, W. Outcomes associated with nonmedical cannabis legalization policy in Canada: taking stock at the 5-year mark. CMAJ 195, E1351–E1353 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Chong, W. W., Acar, Z. I., West, M. L. & Wong, F. A scoping review on the medical and recreational use of cannabis during the COVID-19 pandemic. Cannabis Cannabinoid Res. 7, 591–602 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Mackie, K. Cannabinoid receptors as therapeutic targets. Annu. Rev. Pharmacol. Toxicol. 46, 101–122 (2006).

Article  PubMed  CAS  Google Scholar 

Movahed, P. et al. Vascular effects of anandamide and N-acylvanillylamines in the human forearm and skin microcirculation. Br. J. Pharmacol. 146, 171–179 (2005).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pacher, P., Batkai, S. & Kunos, G. Cardiovascular pharmacology of cannabinoids. Handb. Exp. Pharmacol. 599-625 (2005).

Pacher, P., Batkai, S. & Kunos, G. Blood pressure regulation by endocannabinoids and their receptors. Neuropharmacology 48, 1130–1138 (2005).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Batkai, S. et al. Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats. Am. J. Physiol. Heart Circ. Physiol 293, H1689–H1695 (2007).

Article  PubMed  CAS  Google Scholar 

Valenta, I. et al. Feasibility evaluation of myocardial cannabinoid type 1 receptor imaging in obesity: a translational approach. JACC Cardiovasc. Imaging 11, 320–332 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Rajesh, M. et al. Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. Diabetes 61, 716–727 (2012).

Article