Timmis, A. et al. European Society of Cardiology: cardiovascular disease statistics 2021. Eur. Heart J. 43, 716–799 (2022).

Article  PubMed  Google Scholar 

Tucker, W. J. et al. Exercise for primary and secondary prevention of cardiovascular disease: JACC focus seminar 1/4. J. Am. Coll. Cardiol. 80, 1091–1106 (2022).

Article  PubMed  Google Scholar 

Collins, R. et al. Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet 388, 2532–2561 (2016).

Article  CAS  PubMed  Google Scholar 

Ridker, P. M. et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N. Engl. J. Med. 377, 1119–1131 (2017).

Article  CAS  PubMed  Google Scholar 

Cole, J. B. & Florez, J. C. Genetics of diabetes mellitus and diabetes complications. Nat. Rev. Nephrol. 16, 377–390 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Theocharis, A. D., Skandalis, S. S., Gialeli, C. & Karamanos, N. K. Extracellular matrix structure. Adv. Drug Deliv. Rev. 97, 4–27 (2016).

Article  CAS  PubMed  Google Scholar 

Barallobre-Barreiro, J. et al. Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110, 419–430 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barallobre-Barreiro, J. et al. Extracellular matrix in heart failure: role of ADAMTS5 in proteoglycan remodeling. Circulation 144, 2021–2034 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Didangelos, A. et al. Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteom. 9, 2048–2062 (2010).

Article  CAS  Google Scholar 

Schlotter, F. et al. Spatiotemporal multi-omics mapping generates a molecular atlas of the aortic valve and reveals networks driving disease. Circulation 138, 377–393 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mecham, R. P. & Ramirez, F. Extracellular determinants of arterial morphogenesis, growth, and homeostasis. Curr. Top. Dev. Biol. 130, 193–216 (2018).

Article  CAS  PubMed  Google Scholar 

Yanagisawa, H. & Yokoyama, U. Extracellular matrix-mediated remodeling and mechanotransduction in large vessels during development and disease. Cell Signal. 86, 110104 (2021).

Article  CAS  PubMed  Google Scholar 

Fu, Y., Zhou, Y., Wang, K., Li, Z. & Kong, W. Extracellular matrix interactome in modulating vascular homeostasis and remodeling. Circ. Res. 134, 931–949 (2024).

Article  CAS  PubMed  Google Scholar 

Sazonova, O. V. et al. Extracellular matrix presentation modulates vascular smooth muscle cell mechanotransduction. Matrix Biol. 41, 36–43 (2015).

Article  CAS  PubMed  Google Scholar 

Li, J. et al. A novel coating of type IV collagen and hyaluronic acid on stent material-titanium for promoting smooth muscle cell contractile phenotype. Mater. Sci. Eng. C. Mater. Biol. Appl. 38, 235–243 (2014).

Article  CAS  PubMed  Google Scholar 

Davis, M. J., Earley, S., Li, Y. S. & Chien, S. Vascular mechanotransduction. Physiol. Rev. 103, 1247–1421 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-U’datt, D., Allen, B. G. & Nattel, S. Role of the lysyl oxidase enzyme family in cardiac function and disease. Cardiovasc. Res. 115, 1820–1837 (2019).

PubMed  Google Scholar 

Holmes, D. F., Lu, Y., Starborg, T. & Kadler, K. E. Collagen fibril assembly and function. Curr. Top. Dev. Biol. 130, 107–142 (2018).

Article  CAS  PubMed  Google Scholar 

Ballester-Servera, C. et al. Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease. Biomed. Pharmacother. 167, 115469 (2023).

Article  CAS  PubMed  Google Scholar 

Bogati, R. et al. The effect of activated FXIII, a transglutaminase, on vascular smooth muscle cells. Int. J. Mol. Sci. 23, 5845 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Remus, E. W. et al. The role of lysyl oxidase family members in the stabilization of abdominal aortic aneurysms. Am. J. Physiol. Heart Circ. Physiol. 303, H1067–H1075 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayashi, K. & Hirayama, E. Age-related changes of wall composition and collagen cross-linking in the rat carotid artery — in relation with arterial mechanics. J. Mech. Behav. Biomed. Mater. 65, 881–889 (2017).

Article  CAS  PubMed  Google Scholar 

Sims, T. J., Rasmussen, L. M., Oxlund, H. & Bailey, A. J. The role of glycation cross-links in diabetic vascular stiffening. Diabetologia 39, 946–951 (1996).

Article  CAS  PubMed  Google Scholar 

Zhu, Y. et al. Cross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topologies. Nat. Commun. 15, 3290 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vaisar, T. et al. Parallel murine and human plaque proteomics reveals pathways of plaque rupture. Circ. Res. 127, 997–1022 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Domagala, D. et al. Cellular, molecular and clinical aspects of aortic aneurysm-vascular physiology and pathophysiology. Cells 13, 274 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, C. et al. Targeted inhibition of matrix metalloproteinase-8 prevents aortic dissection in a murine model. Cells 11, 3218 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma, Z. et al. Peptide vaccine against ADAMTS-7 ameliorates atherosclerosis and postinjury neointima hyperplasia. Circulation 147, 728–742 (2023).

Article  CAS  PubMed  Google Scholar 

Jariwala, N. et al. Matrikines as mediators of tissue remodelling. Adv. Drug Deliv. Rev. 185, 114240 (2022).

Article  CAS  PubMed  Google Scholar 

Abdollahi, A., Hlatky, L. & Huber, P. E. Endostatin: the logic of antiangiogenic therapy. Drug Resist. Updates 8, 59–74 (2005).

Article  CAS  Google Scholar 

Moulton, K. S. et al. Loss of collagen XVIII enhances neovascularization and vascular permeability in atherosclerosis. Circulation 110, 1330–1336 (2004).

Article  CAS  PubMed  Google Scholar 

Zeng, X., Chen, J., Miller, Y. I., Javaherian, K. & Moulton, K. S. Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis. J. Lipid Res. 46, 1849–1859 (2005).