The molecular structure of LDL has finally been elucidated

Goldstein, J. L. & Brown, M. S. Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. Proc. Natl Acad. Sci. 70, 2804–2808 (1973).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Segrest, J. P., Jones, M. K., De Loof, H. & Dashti, N. Structure of apolipoprotein B-100 in low density lipoproteins. J. Lipid Res. 42, 1346–1367 (2001).

Article  CAS  PubMed  Google Scholar 

Ren, G. et al. Model of human low-density lipoprotein and bound receptor based on CryoEM. Proc. Natl Acad. Sci. 107, 1059–1064 (2010).

Article  CAS  PubMed  Google Scholar 

Berndsen, Z. T. & Cassidy, C. K. The structure of apolipoprotein B100 from human low-density lipoprotein. Nature https://doi.org/10.1038/s41586-024-08467-w (2024).

Article  PubMed  Google Scholar 

Reimund, M. et al. Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor. Nature https://doi.org/10.1038/s41586-024-08223-0 (2024).

Article  PubMed  Google Scholar 

Wu, X. & Rapoport, T. A. Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies). Proc. Natl Acad. Sci. 118, e2115001118 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rudenko, G. et al. Structure of the LDL receptor extracellular domain at endosomal pH. Science 298, 2353–2358 (2002).

Article  CAS  PubMed  Google Scholar 

Chemello, K. et al. Lipoprotein(a) cellular uptake ex vivo and hepatic capture in vivo is insensitive to PCSK9 inhibition with alirocumab. JACC Basic Transl. Sci. 5, 549–557 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Islam, M. M., Tamlander, M., Hlushchenko, I., Ripatti, S. & Pfisterer, S. G. Large-scale functional characterization of low-density lipoprotein receptor gene variants improves risk assessment in cardiovascular disease. JACC Basic Transl. Sci. https://doi.org/10.1016/j.jacbts.2024.10.006 (2024).

Article  Google Scholar 

留言 (0)

沒有登入
gif