Garcinia kola treatment exhibits immunomodulatory properties while not affecting type 1 diabetes development in an experimental mouse model

1. Greenbaum, C, VanBuecken, D, Lord, S (2019) Disease-modifying therapies in type 1 diabetes: a look into the future of diabetes practice. Drugs 79: 43–61.
Google Scholar | Crossref | Medline2. Coppieters, K, Von Herrath, M (2018) The development of immunotherapy strategies for the treatment of type 1 diabetes. Front Med 5: 283.
Google Scholar | Crossref3. Like, AA, Rossini, AA (1976) Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193: 415–417.
Google Scholar | Crossref | Medline | ISI4. Cetkovic-Cvrlje, M, Thinamany, S, Bruner, KA (2017) Bisphenol A (BPA) aggravates multiple low-dose streptozotocin-induced type 1 diabetes in C57BL/6 mice. J Immunot 14: 160–168.
Google Scholar | Crossref | Medline5. Lu, J, Liu, J, Li, L, et al. (2020) Cytokines in type 1 diabetes: Mechanisms of action and immunotherapeutic targets. Clinical & translational immunology 9: e1122.
Google Scholar | Crossref | Medline6. Cetkovic-Cvrlje, M, Uckun, FM (2005) Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple low doses of streptozotocin. Clin Immunol 114: 299–306.
Google Scholar | Crossref | Medline7. Cetkovic-Cvrlje, M, Olson, M, Ghate, K (2012) Targeting Janus tyrosine kinase 3 (JAK3) with an inhibitor induces secretion of TGF-β by CD4+ T cells. Cell Mol Immunol 9: 350–360.
Google Scholar | Crossref | Medline8. Adaramoye, OA (2012) Antidiabetic effect of Kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats. Afr Health Sci 12: 498–506.
Google Scholar | Medline9. Ayepola, OR, Chegou, NN, Brooks, NL, et al. (2013) Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses. BMC Compl Alternative Med 13: 363.
Google Scholar | Crossref | Medline10. Adedara, IA, Awogbindin, IO, Anamelechi, JP, et al. (2015) Garcinia kolaseed ameliorates renal, hepatic, and testicular oxidative damage in streptozotocin-induced diabetic rats. Pharmaceut Biol 53: 695–704.
Google Scholar | Crossref | Medline11. Farombi, EO, Hansen, M, Ravn-Haren, G, et al. (2004) Commonly consumed and naturally occurring dietary substances affect biomarkers of oxidative stress and DNA damage in healthy rats. Food Chem Toxicol 42: 1315–1322.
Google Scholar | Crossref | Medline12. Tebekeme, O (2009) In vitro antioxidant and free radical scavenging activities of Garcinia kola seeds. Food Chem Toxicol 47: 2620–2623.
Google Scholar | Crossref | Medline13. Abarikwu, SO, Farombi, EO, Kashyap, MP, et al. (2011) Kolaviron protects apoptotic cell death in PC12 cells exposed to atrazine. Free Radic Res 45: 1061–1073.
Google Scholar | Crossref | Medline | ISI14. Ogunmoyole, T, Olalekan, OO, Fatai, O, et al. (2012) Antioxidant and phytochemical profile of aqueous and ethanolic extract of Garcinia kola. J Pharmacogn Phytotherapy 4: 66–74.
Google Scholar15. Lee, G, Goosens, KA (2015) Sampling blood from the lateral tail vein of the rat. JoVE : JoVE 18: e52766.
Google Scholar16. Kuiper, J, Moran, M, Cetkovic-Cvrlje, M (2016) Exposure to polychlorinated biphenyl-153 decreases incidence of autoimmune Type 1 diabetes in non-obese diabetic mice. J Immunot 13: 850–860.
Google Scholar | Crossref | Medline17. Okoko, T, Ere, D (2013) Some bioactive potentials of two biflavanols isolated from Garcinia kola on cadmium-induced alterations of raw U937 cells and U937-derived macrophages. Asian Pacific Journal of Tropical Medicine 6: 43–48.
Google Scholar | Crossref | Medline18. Abarikwu, SO (2014) Kolaviron, a natural flavonoid from the seeds of Garcinia kola, reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion, and inflammatory transcription factors, ERK1/2, NF-κB, p38, Akt, p-c-JUN and JNK. Biochim Biophys Acta Gen Subj 1840: 2373–2381.
Google Scholar | Crossref19. Wallert, M, Bauer, J, Kluge, S, et al. (2019) The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response. Redox Biology 24: 101166–101210.
Google Scholar | Crossref | Medline20. Nworu, CS, Akah, PA, Esimone, CO, et al. (2008) Immunomodulatory Activities of Kolaviron, a Mixture of Three Related Biflavonoids ofGarcinia kolaHeckel. Immunopharmacol Immunotoxicol 30: 317–332.
Google Scholar | Crossref | Medline21. Dada, A (2009) Effects of ethanolic extracts of Garcinia kola seeds on growth and haematology of catfish (Clarias gariepinus) broodstock. Afr J Agric Res 4: 344–347.
Google Scholar22. Uko, OJ, Usman, A, Ataja, AM (2001) Some biological activities of Garcinia kola in growing rats. Vet Arh 71: 287–297.
Google Scholar23. Esiegwu, AC, Enyenihi, GE, Obikaonu, HO, et al. (2013) Effects of dietary intake of Garcinia kola seed meal (GKSM) on the internal organs of juvenile rabbits. Int J Agric Biosci 2: 302–305.
Google Scholar24. Buba, CI, Okhale, SE, Muazzam, I (2016) Garcinia kola: The phytochemistry, pharmacology, and therapeutic applications. Int J Pharmacogn 3: 67–81.
Google Scholar25. Iwu, MM, Igboko, OA, Okunji, CO, et al. (1990) Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola. J Pharm Pharmacol 42: 290–292.
Google Scholar | Crossref | Medline | ISI26. Farahna, M, Seke Etet, PF, Osman, SY, et al. (2017) Garcinia kola aqueous suspension prevents cerebellar neurodegeneration in long-term diabetic rat - a type 1 diabetes mellitus model. J Ethnopharmacol 195: 159–165.
Google Scholar | Crossref | Medline27. Iwu, MM (1985) Antihepatoxic constituents ofGarcinia kola seeds. Experientia 41: 699–700.
Google Scholar | Crossref | Medline28. Ajayi, SA, Ofusori, DA, Ojo, GB, et al. (2011) The microstructural effects of aqueous extract of Garcinia kola (Linn) on the hippocampus and cerebellum of malnourished mice. Asian Pacific Journal of Tropical Biomedicine 1: 261–265.
Google Scholar | Crossref | Medline29. Chinedu, I, Uhegbu, FO, Chukwuechefulam, IK, et al. (2013) Acute administration of aqueous extract of Garcinia kola on daily blood glucose level and selected biochemical indices in longevity Wistar albino rats. International Journal of Microbiology and Mycology 1: 7–12.
Google Scholar30. Adaramoye, OA, Adeyemi, EO (2006) Hypoglycaemic and hypolipidemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia Kola in streptozotocin-induced diabetes mellitus rats. J Pharm Pharmacol 58: 121–128.
Google Scholar | Crossref | Medline31. Tchimene, MK, Anaga, AO, Ugwoke, CEC, et al. (2016) Anti-diabetic Profile of Extract, Kolaviron, Biflavonoids and Garcinoic acid from Garcinia kola seeds. International Journal of Current Microbiology and Applied Sciences 5: 317–322.
Google Scholar | Crossref32. Vandenberg, LN, Welshons, WV, Vom Saal, FS, et al. (2014) Should oral gavage be abandoned in toxicity testing of endocrine disruptors? Environ Health : A Global Access Science Source 13: 46.
Google Scholar | Crossref | Medline

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