Mendelian randomization reveals predictive, preventive, and personalized insights into inflammatory bowel disease: the role of gut microbiome and circulating inflammatory proteins

Hemmer A, Forest K, Rath J, et al. Inflammatory bowel disease: a concise review. S D Med. 2023;76(9):416–23.

PubMed  Google Scholar 

Lamb CA, Kennedy NA, Raine T, et al. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut. 2019;68(Suppl 3):s1–106.

Article  PubMed  Google Scholar 

Kaplan GG, Ng SC. Globalisation of inflammatory bowel disease: perspectives from the evolution of inflammatory bowel disease in the UK and China. Lancet Gastroenterol Hepatol. 2016;1(4):307–16.

Article  PubMed  Google Scholar 

Zuo T, Ng SC. The gut microbiota in the pathogenesis and therapeutics of inflammatory bowel disease. Front Microbiol. 2018;9:2247.

Article  PubMed  PubMed Central  Google Scholar 

Alatab S, Sepanlou SG, Ikuta K, Vahedi H, Bisignano C, Safiri S, et al. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2020;5(1):17–30.

Article  Google Scholar 

Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L. Crohn’s disease. Lancet. 2017;389(10080):1741–55.

Article  PubMed  Google Scholar 

Hodson R. Inflammatory bowel disease. Nature. 2016;540(7634):S97.

Article  CAS  PubMed  Google Scholar 

Bretto E, Ribaldone DG, Caviglia GP, Saracco GM, Bugianesi E, Frara S. Inflammatory bowel disease: emerging therapies and future treatment strategies. Biomedicines. 2023;11(8):2249.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114):2769-2778.10.

Article  PubMed  Google Scholar 

Khoury MJ, Iademarco MF, Riley WT. Precision public health for the era of precision medicine. Am J Prev Med. 2016;50(3):398-401.11.

Article  PubMed  Google Scholar 

Flores M, Glusman G, Brogaard K, Price ND, Hood L. P4 medicine: how systems medicine will transform the healthcare sector and society. Per Med. 2013;10(6):565-576.12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mirnezami R, Nicholson J, Darzi A. Preparing for precision medicine. N Engl J Med. 2012;366(6):489–91.

Article  PubMed  Google Scholar 

Peck RW. Precision medicine is not just genomics: the right dose for every patient. Annu Rev Pharmacol Toxicol. 2018;58(105–22):15.

Google Scholar 

Schmidt TS, Raes J, Bork P. The human gut microbiome: from association to modulation. Cell. 2018;172(6):1198-1215. 16.

Article  CAS  PubMed  Google Scholar 

Honda K, Littman DR. The microbiota in adaptive immune homeostasis and disease. Nature. 2016;535(7610):75–84.

Article  CAS  PubMed  Google Scholar 

Ding RX, Goh WR, Wu RN, Yue XQ, Luo X, Khine WWT, et al. Revisit gut microbiota and its impact on human health and disease. J Food Drug Anal. 2019;27(3):623–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caruso R, Lo BC, Núñez G. Host-microbiota interactions in inflammatory bowel disease. Nat Rev Immunol. 2020;20(7):411–26.

Article  CAS  PubMed  Google Scholar 

Lavelle A, Sokol H. Gut microbiota-derived metabolites as key actors in inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2020;17(4):223–37.

Article  PubMed  Google Scholar 

Palmela C, Chevarin C, Xu Z, Torres J, Sevrin G, Hirten R, et al. Adherent-invasive Escherichia coli in inflammatory bowel disease. Gut. 2018;67(3):574–87.

Article  CAS  PubMed  Google Scholar 

Martini E, Krug SM, Siegmund B, Neurath MF, Becker C. Mend your fences: the epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell Mol Gastroenterol Hepatol. 2017;4(1):33–46.

Article  PubMed  PubMed Central  Google Scholar 

Parada Venegas D, De la Fuente MK, Landskron G, González MJ, Quera R, Dijkstra G, et al. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front Immunol. 2019;10:277.

Article  PubMed  PubMed Central  Google Scholar 

Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell. 2016;165(6):1332–45.

Article  CAS  PubMed  Google Scholar 

Boyko N, Costigliola V, Golubnitschaja O. Microbiome in the framework of predictive, preventive and personalised medicine. In: Boyko N, Golubnitschaja O, editors. Microbiome in 3P medicine strategies: the first exploitation guide. Cham: Springer. In: Boyko N, Golubnitschaja O, editors. Microbiome in 3P medicine strategies: the first exploitation guide. Cham: Springer International Publishing. 2023. p. 1–8.

Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Friedrich M, Pohin M, Powrie F. Cytokine networks in the pathophysiology of inflammatory bowel disease. Immunity. 2019;50(4):992–1006.

Article  CAS  PubMed  Google Scholar 

Neurath MF. Cytokines in inflammatory bowel disease. Nat Rev Immunol. 2014;14(5):329–42.

Article  CAS  PubMed  Google Scholar 

Chovatiya R, Medzhitov R. Stress, inflammation, and defense of homeostasis. Mol Cell. 2014;54(2):281–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park JH, Peyrin-Biroulet L, Eisenhut M, Shin JI. IBD immunopathogenesis: a comprehensive review of inflammatory molecules. Autoimmun Rev. 2017;16(4):416–26.

Article  CAS  PubMed  Google Scholar 

Harbord M, Eliakim R, Bettenworth D, Karmiris K, Katsanos KH, Kopylov U, et al. Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 2: Curr Manag J Crohns Colitis. 2017;11(7):769–84.

Google Scholar 

Schirmer M, Garner A, Vlamakis H, Xavier RJ. Microbial genes and pathways in inflammatory bowel disease. Nat Rev Microbiol. 2019;17(8):497–511.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37(7):658–65.

Article  PubMed  PubMed Central  Google Scholar 

Davies NM, Holmes MV, Davey SG. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018;12(362):k601.

Article  Google Scholar 

Burgess S, Bowden J, Fall T, Ingelsson E, Thompson SG. Sensitivity analyses for robust causal inference from Mendelian randomization analyses with multiple genetic variants. Epidemiology. 2017;28(1):30–42.

Article  PubMed  Google Scholar 

Zhao J, Feng Q, Wei WQ. Integration of omics and phenotypic data for precision medicine. Methods Mol Biol. 2022;2486:19–35.

Article  CAS  PubMed  Google Scholar 

Kurilshikov A, Medina-Gomez C, Bacigalupe R, et al. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat Genet. 2021;53(2):156–65.

留言 (0)

沒有登入
gif