Malhi GS, Mann JJ. Depression. Lancet. 2018;392(10161):2299–312.

Article  PubMed  Google Scholar 

Diseases GBD, Injuries C. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403(10440):2133–61.

Article  Google Scholar 

Kiecolt-Glaser JK, Derry HM, Fagundes CP. Inflammation: depression fans the flames and feasts on the heat. Am J Psychiatry. 2015;172(11):1075–91.

Article  PubMed  PubMed Central  Google Scholar 

Collaborators C-MD: Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet 2021;398(10312):1700–1712.

Patton R, Paval DR, McDonald JJ, Brown D, Gallagher IJ, Skipworth RJE, McMillan DC, Dolan RD, Fallon M, Laird BJA. Relationship between cytokines and symptoms in people with incurable cancer: a systematic review. Crit Rev Oncol Hematol. 2021;159: 103222.

Article  PubMed  Google Scholar 

Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 2006;27(1):24–31.

Article  CAS  PubMed  Google Scholar 

Beurel E, Toups M, Nemeroff CB. The bidirectional relationship of depression and inflammation: double trouble. Neuron. 2020;107(2):234–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sonnenburg JL, Backhed F. Diet-microbiota interactions as moderators of human metabolism. Nature. 2016;535(7610):56–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Metwaly A, Reitmeier S, Haller D. Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders. Nat Rev Gastroenterol Hepatol. 2022;19(6):383–97.

Article  PubMed  Google Scholar 

Thaiss CA, Zeevi D, Levy M, Zilberman-Schapira G, Suez J, Tengeler AC, Abramson L, Katz MN, Korem T, Zmora N, et al. Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell. 2014;159(3):514–29.

Article  CAS  PubMed  Google Scholar 

Thaiss CA, Levy M, Korem T, Dohnalova L, Shapiro H, Jaitin DA, David E, Winter DR, Gury-BenAri M, Tatirovsky E et al. Microbiota diurnal rhythmicity programs host transcriptome oscillations. Cell. 2016;167(6):1495–1510 e1412.

Wang R, Cai Y, Lu W, Zhang R, Shao R, Yau SY, Stubbs B, McIntyre RS, Su KP, Xu G, et al. Exercise effect on the gut microbiota in young adolescents with subthreshold depression: a randomized psychoeducation-controlled Trial. Psychiatry Res. 2023;319: 115005.

Article  CAS  PubMed  Google Scholar 

Ullah H, Di Minno A, Esposito C, El-Seedi HR, Khalifa SAM, Baldi A, Greco A, Santonastaso S, Cioffi V, Sperandeo R, et al. Efficacy of a food supplement based on S-adenosyl methionine and probiotic strains in subjects with subthreshold depression and mild-to-moderate depression: a monocentric, randomized, cross-over, double-blind, placebo-controlled clinical trial. Biomed Pharmacother. 2022;156: 113930.

Article  CAS  PubMed  Google Scholar 

Golubnitschaja O, Watson ID, Topic E, Sandberg S, Ferrari M, Costigliola V. Position paper of the EPMA and EFLM: a global vision of the consolidated promotion of an integrative medical approach to advance health care. EPMA J. 2013;4(1):12.

Article  PubMed  PubMed Central  Google Scholar 

Musazadeh V, Zarezadeh M, Faghfouri AH, Keramati M, Jamilian P, Jamilian P, Mohagheghi A, Farnam A. Probiotics as an effective therapeutic approach in alleviating depression symptoms: an umbrella meta-analysis. Crit Rev Food Sci Nutr. 2023;63(26):8292–300.

Article  CAS  PubMed  Google Scholar 

Aslam H, Lotfaliany M, So D, Berding K, Berk M, Rocks T, Hockey M, Jacka FN, Marx W, Cryan JF et al. Fiber intake and fiber intervention in depression and anxiety: a systematic review and meta-analysis of observational studies and randomized controlled trials. Nutr Rev. 2023:nuad143. https://doi.org/10.1093/nutrit/nuad143.

Zhang Q, Chen B, Zhang J, Dong J, Ma J, Zhang Y, Jin K, Lu J. Effect of prebiotics, probiotics, synbiotics on depression: results from a meta-analysis. BMC Psychiatry. 2023;23(1):477.

Article  PubMed  PubMed Central  Google Scholar 

Cruz-Pereira JS, Rea K, Nolan YM, O’Leary OF, Dinan TG, Cryan JF. Depression’s unholy trinity: dysregulated stress, immunity, and the microbiome. Annu Rev Psychol. 2020;71:49–78.

Article  PubMed  Google Scholar 

Golubnitschaja O, Baban B, Boniolo G, Wang W, Bubnov R, Kapalla M, Krapfenbauer K, Mozaffari MS, Costigliola V. Medicine in the early twenty-first century: paradigm and anticipation - EPMA position paper 2016. EPMA J. 2016;7(1):23.

Article  PubMed  PubMed Central  Google Scholar 

Golubnitschaja O, Kinkorova J, Costigliola V. Predictive, preventive and personalised medicine as the hardcore of “Horizon 2020”: EPMA position paper. EPMA J. 2014;5(1):6.

Article  PubMed  PubMed Central  Google Scholar 

Hou H, Feng X, Li Y, Meng Z, Guo D, Wang F, Guo Z, Zheng Y, Peng Z, Zhang W, et al. Suboptimal health status and psychological symptoms among Chinese college students: a perspective of predictive, preventive and personalised health. EPMA J. 2018;9(4):367–77.

Article  PubMed  PubMed Central  Google Scholar 

Xi Y, Zhang C, Feng Y, Zhao S, Zhang Y, Duan G, Wang W, Wang J. Genetically predicted the causal relationship between gut microbiota and infertility: bidirectional Mendelian randomization analysis in the framework of predictive, preventive, and personalized medicine. EPMA J. 2023;14(3):405–16.

Article  PubMed  PubMed Central  Google Scholar 

Chen HW, Zhou R, Cao BF, Liu K, Zhong Q, Huang YN, Liu HM, Zhao JQ, Wu XB. The predictive, preventive, and personalized medicine of insomnia: gut microbiota and inflammation. EPMA J. 2023;14(4):571–83.

Article  PubMed  Google Scholar 

Emdin CA, Khera AV, Kathiresan S. Mendelian randomization. JAMA. 2017;318(19):1925–6.

Article  PubMed  Google Scholar 

Huang Y, Zheng E, Hu M, Yang X, Lan Q, Yu Y, Xu B. The impact of depression-mediated gut microbiota composition on irritable bowel syndrome: a Mendelian study. J Affect Disord. 2024;360:15–25.

Article  CAS  PubMed  Google Scholar 

Kurilshikov A, Medina-Gomez C, Bacigalupe R, Radjabzadeh D, Wang J, Demirkan A, Le Roy CI, Raygoza Garay JA, Finnicum CT, Liu X, et al. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat Genet. 2021;53(2):156–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao JH, Stacey D, Eriksson N, Macdonald-Dunlop E, Hedman AK, Kalnapenkis A, Enroth S, Cozzetto D, Digby-Bell J, Marten J, et al. Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets. Nat Immunol. 2023;24(9):1540–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ou G, Wu J, Wang S, Jiang Y, Chen Y, Kong J, Xu H, Deng L, Zhao H, Chen X et al. Dietary factors and risk of gout: a two-sample Mendelian randomization study. Foods. 2024;13(8).

Wang S, Ou G, Wu J, Chen Y, Xu L, Xu H: Genetically predicted peripheral immune cells mediate the effect of gut microbiota on influenza susceptibility. Int J Mol Sci. 2024;25(14).

Kupfer DJ, Frank E, Phillips ML. Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet. 2012;379(9820):1045–55.

Article  PubMed  Google Scholar 

Chen JJ, Bai SJ, Li WW, Zhou CJ, Zheng P, Fang L, Wang HY, Liu YY, Xie P. Urinary biomarker panel for diagnosing patients with depression and anxiety disorders. Transl Psychiatry. 2018;8(1):192.

Article  CAS  PubMed  PubMed Central  Google Scholar 

King DR, Salako DC, Arthur-Bentil SK, Rubin AE, Italiya JB, Tan JS, Macris DG, Neely HK, Palka JM, Grodin JL, et al. Relationship between novel inflammatory biomarker galectin-3 and depression symptom severity in a large community-based sample. J Affect Disord. 2021;281:384–9.

Article  CAS  PubMed  Google Scholar 

Carvalho AF, Kohler CA, McIntyre RS, Knochel C, Brunoni AR, Thase ME, Quevedo J, Fernandes BS, Berk M. Peripheral vascular endothelial growth factor as a novel depression biomarker: a meta-analysis. Psychoneuroendocrinology. 2015;62:18–26.

Article  CAS  PubMed  Google Scholar 

Collins SM, Surette M, Bercik P. The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol. 2012;10(11):735–42.