The KT Jeang retrovirology prize 2023: Thumbi Ndung’u

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Ndung’u T, Gaseitsiwe S, Sepako E, Doualla-Bell F, Peter T, Kim S, Thior I, Novitsky VA, Essex M. Major histocompatibility complex class II (HLA-DRB and -DQB) allele frequencies in Botswana: association with human immunodeficiency virus type 1 infection. Clin Diagn Lab Immunol. 2005;12:1020–8.

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Novitsky V, Gilbert P, Peter T, McLane MF, Gaolekwe S, Rybak N, Thior I, Ndung’u T, Marlink R, Lee TH, Essex M. Association between virus-specific T-cell responses and plasma viral load in human immunodeficiency virus type 1 subtype C infection. J Virol. 2003;77:882–90.

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Shapiro RL, Ndung’u T, Lockman S, Smeaton LM, Thior I, Wester C, Stevens L, Sebetso G, Gaseitsiwe S, Peter T, Essex M. Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk. J Infect Dis. 2005;192:713–9.

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Naicker DD, Werner L, Kormuth E, Passmore JA, Mlisana K, Karim SA. Ndung’u T: Interleukin-10 promoter polymorphisms influence HIV-1 susceptibility and primary HIV-1 pathogenesis. J Infect Dis. 2009;200:448–52.

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Reddy K, Ooms M, Letko M, Garrett N, Simon V, Ndung’u T. Functional characterization of vif proteins from HIV-1 infected patients with different APOBEC3G haplotypes. AIDS. 2016;30:1723–9.

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Sewram S, Singh R, Kormuth E, Werner L, Mlisana K, Karim SS, Ndung’u T, Team CAIS. Human TRIM5alpha expression levels and reduced susceptibility to HIV-1 infection. J Infect Dis. 2009;199:1657–63.

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Singh R, Patel V, Mureithi MW, Naranbhai V, Ramsuran D, Tulsi S, Hiramen K, Werner L, Mlisana K, Altfeld M, et al. TRIM5alpha and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment. J Virol. 2014;88:4291–303.

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Wright JK, Naidoo VL, Brumme ZL, Prince JL, Claiborne DT, Goulder PJ, Brockman MA, Hunter E. Ndung’u T: impact of HLA-B*81-associated mutations in HIV-1 gag on viral replication capacity. J Virol. 2012;86:3193–9.

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Barton JP, Rajkoomar E, Mann JK, Murakowski DK, Toyoda M, Mahiti M, Mwimanzi P, Ueno T, Chakraborty AK. Ndung’u T: modelling and in vitro testing of the HIV-1 Nef fitness landscape. Virus Evol. 2019;5:vez029.

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Ferguson AL, Mann JK, Omarjee S, Ndung’u T, Walker BD, Chakraborty AK. Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design. Immunity. 2013;38:606–17.

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Mann JK, Barton JP, Ferguson AL, Omarjee S, Walker BD, Chakraborty A, Ndung’u T. The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing. PLoS Comput Biol. 2014;10:e1003776.

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