Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques

Castro-Gonzalez S, Colomer-Lluch M, Serra-Moreno R. Barriers for HIV cure: the Latent Reservoir. AIDS Res Hum Retroviruses. 2018;34(9):739–59.

Article  PubMed  PubMed Central  Google Scholar 

Koenig S, Gendelman HE, Orenstein JM, Canto MCD, Pezeshkpour GH, Yungbluth M, Janotta F, Aksamit A, Martin MA, Fauci AS. Detection of AIDS Virus in Macrophages in Brain tissue from AIDS patients with Encephalopathy. Science; 1986.

Coleman CM, Wu L. HIV interactions with monocytes and dendritic cells: viral latency and reservoirs. Retrovirology. 2009;6(1):51.

Article  PubMed  PubMed Central  Google Scholar 

Kumar A, Abbas W, Herbein G. HIV-1 latency in Monocytes/Macrophages. Viruses. 2014;6(4):1837–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moretti S, Virtuoso S, Sernicola L, Farcomeni S, Maggiorella MT, Borsetti A. Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS. Pathogens 2021, 10(8).

Obregon-Perko V, Bricker K, Chahroudi A. The Brain retains: Nonhuman Primate Models for Pediatric HIV-1 in the CNS. Curr HIV/AIDS Rep. 2020;17(4):343–53.

Article  PubMed  PubMed Central  Google Scholar 

Raghavan R, Stephens EB, Joag SV, Adany I, Pinson DM, Li Z, Jia F, Sahni M, Wang C, Leung K, Foresman L, Narayan O. Neuropathogenesis of chimeric Simian/Human immunodeficiency virus infection in Pig-tailed and Rhesus Macaques. Brain Pathol. 2008;7(3):851–61.

Article  PubMed Central  Google Scholar 

Hsu DC, Sunyakumthorn P, Wegner M, Schuetz A, Silsorn D, Estes JD, Deleage C, Tomusange K, Lakhashe SK, Ruprecht RM, Lombardini E, Im-Erbsin R, Kuncharin Y, Phuang-Ngern Y, Inthawong D, Chuenarom W, Burke R, Robb ML, Ndhlovu LC, Ananworanich J, Valcour V, O’Connell RJ, Spudich S, Michael NL, Vasan S. Central nervous system inflammation and infection during early, nonaccelerated simian-human immunodeficiency virus infection in Rhesus Macaques. J Virol 2018, 92(11).

Humbert M, Rasmussen RA, Song R, Ong H, Sharma P, Chenine AL, Kramer VG, Siddappa NB, Xu W, Else JG, Novembre FJ, Strobert E, O’Neil SP, Ruprecht RM. SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys. Retrovirology. 2008;5:94.

Article  PubMed  PubMed Central  Google Scholar 

Zhuang K, Leda AR, Tsai L, Knight H, Harbison C, Gettie A, Blanchard J, Westmoreland S, Cheng-Mayer C. Emergence of CD4 independence envelopes and astrocyte infection in R5 simian-human immunodeficiency Virus Model of Encephalitis. J Virol. 2014;88(15):8407–20.

Article  PubMed  PubMed Central  Google Scholar 

Buch S, Sui Y, Dhillon N, Potula R, Zien C, Pinson D, Li S, Dhillon S, Nicolay B, Sidelnik A, Li C, Villinger T, Bisarriya K, Narayan O. Investigations on four host response factors whose expression is enhanced in X4 SHIV encephalitis. J Neuroimmunol. 2004;157(1–2):71–80.

Article  CAS  PubMed  Google Scholar 

Bar KJ, Coronado E, Hensley-McBain T, O’Connor MA, Osborn JM, Miller C, Gott TM, Wangari S, Iwayama N, Ahrens CY, Smedley J, Moats C, Lynch RM, Haddad EK, Haigwood NL, Fuller DH, Shaw GM, Klatt NR, Manuzak JA. Simian-Human Immunodeficiency Virus SHIV.CH505 Infection of Rhesus Macaques Results in Persistent Viral Replication and Induces Intestinal Immunopathology. J Virol 2019, 93(18).

Barton K, Winckelmann A, Palmer S. HIV-1 Reservoirs during suppressive therapy. Trends Microbiol. 2016;24(5):345–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chan CN, Trinité B, Lee CS, Mahajan S, Anand A, Wodarz D, Sabbaj S, Bansal A, Goepfert PA, Levy DN. HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells. Retrovirology 2016, 13.

Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, Quinn TC, Chadwick K, Margolick J, Brookmeyer R, Gallant J, Markowitz M, Ho DD, Richman DD, Siliciano RF. Identification of a Reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science; 1997.

Pinkevych M, Cromer D, Tolstrup M, Grimm AJ, Cooper DA, Lewin SR, Søgaard OS, Rasmussen TA, Kent SJ, Kelleher AD, Davenport MP. HIV Reactivation from latency after treatment interruption occurs on average every 5–8 days—implications for HIV Remission. PLoS Pathog. 2015;11(7):e1005000.

Article  PubMed  PubMed Central  Google Scholar 

Bednar MM, Sturdevant CB, Tompkins LA, Arrildt KT, Dukhovlinova E, Kincer LP, Swanstrom R. Compartmentalization, viral evolution, and viral latency of HIV in the CNS. Curr HIV/AIDS Rep. 2015;12(2):262–71.

Article  PubMed  PubMed Central  Google Scholar 

Sonti S, Sharma AL, Tyagi M. HIV-1 persistence in the CNS: mechanisms of latency, pathogenesis and an update on eradication strategies. Virus Res. 2021;303:198523.

Article  CAS  PubMed  Google Scholar 

Balcom EF, Roda WC, Cohen EA, Li MY, Power C. HIV-1 persistence in the central nervous system: viral and host determinants during antiretroviral therapy. Curr Opin Virol. 2019;38:54–62.

Article  CAS  PubMed  Google Scholar 

Wallet C, De Rovere M, Van Assche J, Daouad F, De Wit S, Gautier V, Mallon PWG, Marcello A, Van Lint C, Rohr O, Schwartz C. Microglial cells: the Main HIV-1 Reservoir in the brain. Front Cell Infect Microbiol. 2019;9:362.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trease AJ, Niu M, Morsey B, Guda C, Byrareddy SN, Buch S, Fox HS. Antiretroviral therapy restores the homeostatic state of microglia in SIV-infected rhesus macaques. J Leukoc Biol 2022.

Schnell G, Spudich S, Harrington P, Price RW, Swanstrom R. Compartmentalized human immunodeficiency virus type 1 originates from long-lived cells in some subjects with HIV-1-associated dementia. PLoS Pathog. 2009;5(4):e1000395.

Article  PubMed  PubMed Central  Google Scholar 

Veenstra M, León-Rivera R, Li M, Gama L, Clements JE, Berman JW. Mechanisms of CNS Viral Seeding by HIV + CD14 + CD16 + Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated Neurocognitive Disorders. mBio 2017, 8(5).

Ko A, Kang G, Hattler JB, Galadima HI, Zhang J, Li Q, Kim W. Macrophages but not astrocytes Harbor HIV DNA in the brains of HIV-1-Infected aviremic individuals on suppressive antiretroviral therapy. J Neuroimmune Pharmacol. 2019;14(1):110–9.

Article  PubMed  Google Scholar 

Bauer AM, Bar KJ. Advances in simian–human immunodeficiency viruses for nonhuman primate studies of HIV prevention and cure. Curr Opin HIV AIDS. 2020;15(5):275–81.

Article  PubMed  Google Scholar 

Joseph SB, Swanstrom R, Kashuba ADM, Cohen MS. Bottlenecks in HIV-1 transmission: insights from the study of founder viruses. Nat Rev Microbiol. 2015;13(7):414–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baalwa J, Wang S, Parrish NF, Decker JM, Keele BF, Learn GH, Yue L, Ruzagira E, Ssemwanga D, Kamali A, Amornkul PN, Price MA, Kappes JC, Karita E, Kaleebu P, Sanders E, Gilmour J, Allen S, Hunter E, Montefiori DC, Haynes BF, Cormier E, Hahn BH, Shaw GM. Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clones. Virology. 2013;436(1):33–48.

Article  CAS  PubMed  Google Scholar 

Li H, Wang S, Kong R, Ding W, Lee F, Parker Z, Kim E, Learn GH, Hahn P, Policicchio B, Brocca-Cofano E, Deleage C, Hao X, Chuang G, Gorman J, Gardner M, Lewis MG, Hatziioannou T, Santra S, Apetrei C, Pandrea I, Alam SM, Liao H, Shen X, Tomaras GD, Farzan M, Chertova E, Keele BF, Estes JD, Lifson JD, Doms RW, Montefiori DC, Haynes BF, Sodroski JG, Kwong PD, Hahn BH, Shaw GM. Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques. Proc Natl Acad Sci U S A. 2016;113(24):3413.

Article  Google Scholar 

Sacktor N, Nakasujja N, Skolasky RL, Rezapour M, Robertson K, Musisi S, Katabira E, Ronald A, Clifford DB, Laeyendecker O, Quinn TC. HIV Subtype D is Associated with Dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, Uganda. Clin Infect Dis. 2009;49(5):780–6.

Article  PubMed  Google Scholar 

Tyor W, Fritz-French C, Nath A. Effect of HIV clade differences on the onset and severity of HIV-associated neurocognitive disorders. J Neurovirol. 2013;19(6):515–22.

Article  PubMed  PubMed Central  Google Scholar 

Bauer AM, Ziani W, Lindemuth E, Kuri-Cervantes L, Li H, Lee F, Watkins M, Ding W, Xu H, Veazey R, Bar KJ. Novel Transmitted/Founder simian-human immunodeficiency viruses for human immunodeficiency virus latency and Cure Research. J Virol 2020, 94(8).

Li H, Wang S, Kong R, Ding W, Lee F, Parker Z, Kim E, Learn GH, Hahn P, Policicchio B, Brocca-Cofano E, Deleage C, Hao X, Chuang G, Gorman J, Gardner M, Lewis MG, Hatziioannou T, Santra S, Apetrei C, Pandrea I, Alam SM, Liao H, Shen X, Tomaras GD, Farzan M, Chertova E, Keele BF, Estes JD, Lifson JD, Doms RW, Montefiori DC, Haynes BF, Sodroski JG, Kwong PD, Hahn BH, Shaw GM. Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques. Proc Natl Acad Sci U S A. 2016;113(24):E3413–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deleage C, Chan CN, Busman-Sahay K, Estes JD. Next-generation in situ hybridization approaches to define and quantify HIV and SIV reservoirs in tissue microenvironments. Retrovirology 2018, 15(4).

Lee CA, Beasley E, Sundar K, Smelkinson M, Vinton C, Deleage C, Matsuda K, Wu F, Estes JD, Lafont BAP, Brenchley JM, Hirsch VM. Simian Immunodeficiency Virus-Infected Memory CD4 + T Cells Infiltrate to the Site of Infected Macrophages in the Neuroparenchyma of a Chronic Macaque Model of Neurological Complications of AIDS. mBio 2020, 11(2).

Li H, Wang S, Lee F, Roark RS, Murphy AI, Smith J, Zhao C, Rando J, Chohan N, Ding Y, Kim E, Lindemuth E, Bar KJ, Pandrea I, Apetrei C, Keele BF, Lifson JD, Lewis MG, Denny TN, Haynes BF, Hahn BH, Shaw GM. New SHIVs and Improved Design Strategy for modeling HIV-1 transmission, immunopathogenesis, Prevention and Cure. J Virol 2021, 95(11).

Roark RS, Li H, Williams WB, Chug H, Mason RD, Gorman J, Wang S, Lee F, Rando J, Bonsignori M, Hwang K, Saunders KO, Wiehe K, Moody MA, Hraber PT, Wagh K, Giorgi EE, Russell RM, Bibollet-Ruche F, Liu W, Connell J, Smith AG, DeVoto J, Murphy AI, Smith J, Ding W, Zhao C, Chohan N, Okumura M, Rosario C, Ding Y, Lindemuth E, Bauer AM, Bar KJ, Ambrozak D, Chao CW, Chuang G, Geng H, Lin BC, Louder MK, Nguyen R, Zhang B, Lewis MG, Raymond DD, Doria-Rose NA, Schramm CA, Douek DC, Roederer M, Kepler TB, Kelsoe G, Mascola JR, Kwong PD, Korber BT, Harrison SC, Haynes BF, Hahn BH, Shaw GM. Recapitulation of HIV-1 env-antibody coevolution in macaques leading to neutralization breadth. Science 2021, 371(6525).

Cenker JJ, Stultz RD, McDonald D. Brain microglial cells are highly susceptible to HIV-1 infection and spread. AIDS Res Hum Retroviruses. 2017;33(11):1155–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borrajo A, Spuch C, Penedo MA, Olivares JM, Agís-Balboa RC. Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis. Ann Med. 2021;53(1):43–69.

Article  CAS  PubMed  Google Scholar 

Burdo TH: Editor’s Commentary for Special Issue, editor. “The role of macrophages in HIV persistence”. J Neuroimmune Pharmacol 2019, 14(1):2–5.

Burdo TH, Lackner A, Williams KC. Monocyte/macrophages and their role in HIV neuropathogenesis. Immunol Rev. 2013;254(1):102–13.

Article  PubMed  PubMed Central  Google Scholar 

Llewellyn GN, Alvarez-Carbonell D, Chateau M, Karn J, Cannon PM. HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. J Neurovirol. 2018;24(2):192–203.

Article  CAS  PubMed  Google Scholar 

Zhang Y-, Ouyang Y-, Liu L-, Chen D-. Blood-brain barrier and neuro-AIDS. Eur Rev Med Pharmacol Sci. 2015;19(24):4927–39.

PubMed  Google Scholar 

Gisslén M, Price RW, Nilsson S. The definition of HIV-associated neurocognitive disorders: are we overestimating the real prevalence? BMC Infect Dis. 2011;11:356.

Article  PubMed  PubMed Central  Google Scholar 

Bhaskaran K, Mussini C, Antinori A, Walker AS, Dorrucci M, Sabin C, Phillips A, Porter K. Changes in the incidence and predictors of human immunodeficiency virus-associated dementia in the era of highly active antiretroviral therapy. Ann Neurol. 2008;63(2):213–21.

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif