Willems L, Burny A, Collete D, Dangoisse O, Dequiedt F, Gatot JS, et al. Genetic determinants of bovine leukemia virus pathogenesis. AIDS Res Hum Retroviruses. 2000;16(16):1787–95.

Article  CAS  PubMed  Google Scholar 

Gillet N, Florins A, Boxus M, Burteau C, Nigro A, Vandermeers F, et al. Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human. Retrovirology. 2007;4:18.

Article  PubMed  PubMed Central  Google Scholar 

Tsutsui T, Kobayashi S, Hayama Y, Yamamoto T. Fraction of bovine leukemia virus-infected dairy cattle developing enzootic bovine leukosis. Prev Vet Med. 2016;1(124):96–101.

Article  Google Scholar 

Burny A, Cleuter Y, Kettmann R, Mammerickx M, Marbaix G, Portetelle D, et al. Bovine leukaemia: facts and hypotheses derived from the study of an infectious cancer. Vet Microbiol. 1988;17(3):197–218.

Article  CAS  PubMed  Google Scholar 

Olson C, Miller L, Miller J, Hoss HE. Transmission of lymphosarcoma from cattle to sheep. Natl Cancer Inst. 1972;49(5):1463–7.

CAS  Google Scholar 

Kenyon S, Ferrer J, McFeely R, Graves DC. Induction of lymphosarcoma in sheep by bovine leukemia virus. J Natl Cancer Inst. 1981;67(5):1157–63.

CAS  PubMed  Google Scholar 

Djilali S, Parodi AL. The BLV-induced leukemia-lymphosarcoma complex in sheep. Vet Immunol Immunopathol. 1989;22(3):233–44.

Article  CAS  PubMed  Google Scholar 

Mammerickx M, Portetelle D, de Clercq K, Burny A. Experimental transmission of enzootic bovine leukosis to cattle, sheep and goats: infectious doses of blood and incubation period of the disease. Leuk Res. 1987;11(4):353–8.

Article  CAS  PubMed  Google Scholar 

Djilali S, Parodi AL, Levy D, Cockerell GL. Development of leukemia and lymphosarcoma induced by bovine leukemia virus in sheep: a hematopathological study. Leukemia. 1987;1(11):777–81.

CAS  PubMed  Google Scholar 

Porta NG, Alvarez I, Suarez Archilla G, Ruiz V, Abdala A, Trono K. Experimental infection of sheep with Bovine leukemia virus (BLV): Minimum dose of BLV-FLK cells and cell-free BLV and neutralization activity of natural antibodies. Rev Argent Microbiol. 2019;51(4):316–23.

PubMed  Google Scholar 

Bartlett PC, Norby B, Byrem TM, Parmelee A, Ledergerber JT, Erskine RJ. Bovine leukemia virus and cow longevity in Michigan dairy herds. J Dairy Sci mars. 2013;96(3):1591–7.

Article  CAS  Google Scholar 

Bartlett PC, Ruggiero VJ, Hutchinson HC, Droscha CJ, Norby B, Sporer KRB, et al. Current developments in the epidemiology and control of enzootic bovine leukosis as caused by bovine leukemia virus. Pathogens: Multidisciplinary Digital Publishing Institute; 2020.

Book  Google Scholar 

White TL, Moore DA. Food for thought for food animal veterinarians. J Am Vet Med Assoc. 2009;235(8):937–41.

Article  PubMed  Google Scholar 

Bartlett P, Sordillo LM, Byrem TM, Norby B, Grooms DL, Swenson CL, et al. Options for the control of bovine leukemia virus in dairy cattle. J Am Vet Med Assoc. 2014;244(8):914–22.

Article  PubMed  Google Scholar 

Nekouei O, VanLeeuwen J, Stryhn H, Kelton D, Keefe G. Lifetime effects of infection with bovine leukemia virus on longevity and milk production of dairy cows. Prev Vet Med. 2016;1(133):1–9.

Article  Google Scholar 

Achachi A, Florins A, Gillet N, Debacq C, Urbain P, Foutsop GM, et al. Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo. Proc Natl Acad Sci USA. 2005;102(29):10309–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gutiérrez G, Rodríguez SM, De Brogniez A, Gillet N, Golime R, Burny A, et al. Vaccination against δ-retroviruses: the bovine leukemia virus paradigm. Viruses. 2014. https://doi.org/10.3390/v6062416.

Article  PubMed  PubMed Central  Google Scholar 

Rodríguez SM, Florins A, Gillet N, de Brogniez A, Sánchez-Alcaraz MT, Boxus M, et al. Preventive and therapeutic strategies for bovine leukemia virus: lessons for HTLV. Viruses. 2011;3(7):1210–48.

Article  PubMed  PubMed Central  Google Scholar 

Juliarena MA, Barrios CN, Lützelschwab CM, Esteban EN, Gutiérrez SE. Bovine leukemia virus current perspectives virus adaptation and treatment. New Jersey: Dove Press; 2017.

Google Scholar 

Abdala A, Alvarez I, Brossel H, Calvinho L, Carignano H, Franco L, et al. BLV: Lessons on vaccine development Retrovirology. BioMed Central. 2019. https://doi.org/10.1186/s12977-019-0488-8.

Article  Google Scholar 

Suárez Archilla G, Gutiérrez G, Camussone C, Calvinho L, Abdala A, Alvarez I, et al. A safe and effective vaccine against bovine leukemia virus. Front Immunol. 2022;13: 980514.

Article  PubMed  PubMed Central  Google Scholar 

Gillet N, Gutiérrez G, Rodriguez SM, de Brogniez A, Renotte N, Alvarez I, et al. Massive depletion of bovine leukemia virus proviral clones located in genomic transcriptionally active sites during primary infection. PLoS Pathog. 2013;9(10):1003687.

Article  Google Scholar 

Derse D, Casey JW. Two Elements in the Bovine Leukemia Virus Long Terminal Repeat That Regulate Gene Expression. Science. 1986;231(4744):1437–40.

Article  CAS  PubMed  Google Scholar 

Katoh I, Yoshinaka Y, Ikawa Y. Bovine leukemia virus trans-activator p38tax activates heterologous promoters with a common sequence known as a cAMP-responsive element or the binding site of a cellular transcription factor ATF. EMBO J févr. 1989;8(2):497–503.

Article  CAS  Google Scholar 

Xiao J, Buehring GC. In vivo protein binding and functional analysis of cis-acting elements in the U3 region of the bovine leukemia virus long terminal repeat. J Virol juill. 1998;72(7):5994–6003.

Article  CAS  Google Scholar 

Rosen CA, Sodroski JG, Kettman R, Burny A, Haseltine WA. Trans activation of the bovine leukemia virus long terminal repeat in BLV-infected cells. Science. 1985;227(4684):320–2.

Article  CAS  PubMed  Google Scholar 

Rosen CA, Sodroski JG, Kettman R, Haseltine WA. Activation of enhancer sequences in type II human T-cell leukemia virus and bovine leukemia virus long terminal repeats by virus-associated trans-acting regulatory factors. J Virol mars. 1986;57(3):738–44.

Article  CAS  Google Scholar 

Derse D. Bovine leukemia virus transcription is controlled by a virus-encoded trans-acting factor and by cis-acting response elements. J Virol. 1987;61(8):2462–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kiss-Toth E, Paca-uccaralertkun S, Unk I, Boros I. Member of the CREB/ATF protein family, but not CREB alpha plays an active role in BLV tax trans activation in vivo. Nucleic Acids Res. 1993;21(16):3677–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alberini CM. Transcription Factors in Long-Term Memory and Synaptic Plasticity. Physiol Rev. 2009;89(1):121–45.

Article  CAS  PubMed  Google Scholar 

D’Auria F, Pietro R. Role of CREB protein family members in human haematological. Malignancies. 2013. https://doi.org/10.5772/55368.

Article  Google Scholar 

Mayr B, Mayr MM, Montminy B. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rew Mol Cell Biol. 2000;2:599–609.

Article  Google Scholar 

Willems L, Kettmann R, Chen G, Portetelle D, Burny A, Derse D. A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat. J Virol. 1992;66(2):766–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adam E, Kerkhofs P, Mammerickx M, Kettmann R, Burny A, Droogmans L, et al. Involvement of the cyclic AMP-responsive element binding protein in bovine leukemia virus expression in vivo. J Virol. 1994;68(9):5845–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adam E, Kerkhofs P, Mammerickx M, Burny A, Kettmann R, Willems L. The CREB, ATF-1, and ATF-2 transcription factors from bovine leukemia virus-infected B lymphocytes activate viral expression. J Virol. 1996;70(3):1990–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nguyên TLA, de Walque S, Veithen E, Dekoninck A, Martinelli V, de Launoit Y, et al. Transcriptional regulation of the bovine leukemia virus promoter by the cyclic AMP-response element modulator τ Isoform. J Biol Chem. 2007;282(29):20854–67.

Article  PubMed  Google Scholar 

Nguyên TLA, Calomme C, Wijmeersch G, Nizet S, Veithen E, Portetelle D, et al. Deacetylase inhibitors and the viral transactivator TaxBLV synergistically activate bovine leukemia virus gene expression via a cAMP-responsive element- and cAMP-responsive element-binding protein-dependent mechanism. J Biol Chem. 2004;279(33):35025–36.

Article  PubMed  Google Scholar 

Pierard V, Guiguen A, Colin L, Wijmeersch G, Vanhulle C, Driessche BV, et al. DNA cytosine methylation in the bovine leukemia virus promoter is associated with latency in a lymphoma-derived B-cell line: potential involvement of direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding. J Biol Chem. 2010;285(25):19434–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van den Broeke A, Bagnis C, Ciesiolka M, Cleuter Y, Gelderblom H, Kerkhofs P, et al. In vivo rescue of a silent tax-deficient bovine leukemia virus from a tumor-derived ovine B-cell line by recombination with a retrovirally transduced wild-type tax gene. J Virol. 1999;73(2):1054–65.