The KT Jeang retrovirology prize 2024: Walther Mothes

Gorlich D, Hartmann E, Prehn S, Rapoport TA. A protein of the endoplasmic reticulum involved early in polypeptide translocation. Nature. 1992;357(6373):47–52.

Article  CAS  PubMed  Google Scholar 

Gorlich D, Prehn S, Hartmann E, Kalies KU, Rapoport TA. A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation. Cell. 1992;71(3):489–503.

Article  CAS  PubMed  Google Scholar 

Gorlich D, Rapoport TA. Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane. Cell. 1993;75(4):615–30.

Article  CAS  PubMed  Google Scholar 

Mothes W, Prehn S, Rapoport TA. Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane. EMBO J. 1994;13(17):3973–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mothes W, Heinrich SU, Graf R, Nilsson I, von Heijne G, Brunner J, Rapoport TA. Molecular mechanism of membrane protein integration into the endoplasmic reticulum. Cell. 1997;89(4):523–33.

Article  CAS  PubMed  Google Scholar 

Heinrich SU, Mothes W, Brunner J, Rapoport TA. The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain. Cell. 2000;102(2):233–44.

Article  CAS  PubMed  Google Scholar 

Mothes W, Boerger AL, Narayan S, Cunningham JM, Young JA. Retroviral entry mediated by receptor priming and low pH triggering of an envelope glycoprotein. Cell. 2000;103(4):679–89.

Article  CAS  PubMed  Google Scholar 

Felbor U, Dreier L, Bryant RA, Ploegh HL, Olsen BR, Mothes W. Secreted cathepsin L generates endostatin from collagen XVIII. EMBO J. 2000;19(6):1187–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Felbor U, Kessler B, Mothes W, Goebel HH, Ploegh HL, Bronson RT, Olsen BR. Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A. 2002;99(12):7883–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sherer NM, Lehmann MJ, Jimenez-Soto LF, Ingmundson A, Horner SM, Cicchetti G, Allen PG, Pypaert M, Cunningham JM, Mothes W. Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. Traffic. 2003;4(11):785–801.

Article  CAS  PubMed  Google Scholar 

Lehmann MJ, Sherer NM, Marks CB, Pypaert M, Mothes W. Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells. J Cell Biol. 2005;170(2):317–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sherer NM, Jin J, Mothes W. Directional spread of surface-associated retroviruses regulated by differential virus-cell interactions. J Virol. 2010;84(7):3248–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sherer NM, Lehmann MJ, Jimenez-Soto LF, Horensavitz C, Pypaert M, Mothes W. Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission. Nat Cell Biol. 2007;9(3):310–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mothes W, Sherer NM, Jin J, Zhong P. Virus cell-to-cell transmission. J Virol. 2010;84(17):8360–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin J, Sherer NM, Heidecker G, Derse D, Mothes W. Assembly of the murine leukemia virus is directed towards sites of cell-cell contact. PLoS Biol. 2009;7(7):e1000163.

Article  PubMed  PubMed Central  Google Scholar 

Sewald X, Ladinsky MS, Uchil PD, Beloor J, Pi R, Herrmann C, Motamedi N, Murooka TT, Brehm MA, Greiner DL, et al. Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Science. 2015;350(6260):563–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sewald X, Gonzalez DG, Haberman AM, Mothes W. In vivo imaging of virological synapses. Nat Commun. 2012;3:1320.

Article  PubMed  Google Scholar 

Zhong P, Agosto LM, Ilinskaya A, Dorjbal B, Truong R, Derse D, Uchil PD, Heidecker G, Mothes W. Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV. PLoS ONE. 2013;8(1):e53138.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong P, Agosto LM, Munro JB, Mothes W. Cell-to-cell transmission of viruses. Curr Opin Virol. 2013;3(1):44–50.

Article  CAS  PubMed  Google Scholar 

Agosto LM, Zhong P, Munro J, Mothes W. Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission. PLoS Pathog. 2014;10(2):e1003982.

Article  PubMed  PubMed Central  Google Scholar 

Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. PLoS Pathog. 2008;4(2):e16.

Article  PubMed  PubMed Central  Google Scholar 

Uchil PD, Hinz A, Siegel S, Coenen-Stass A, Pertel T, Luban J, Mothes W. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. J Virol. 2013;87(1):257–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pertel T, Hausmann S, Morger D, Zuger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, et al. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature. 2011;472(7343):361–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pi R, Iwasaki A, Sewald X, Mothes W, Uchil PD. Murine leukemia virus exploits innate sensing by toll-like receptor 7 in B-1 cells to establish infection and locally spread in mice. J Virol. 2019;93(21).

Uchil PD, Pi R, Haugh KA, Ladinsky MS, Ventura JD, Barrett BS, Santiago ML, Bjorkman PJ, Kassiotis G, Sewald X, et al. A protective role for the lectin CD169/Siglec-1 against a pathogenic murine retrovirus. Cell Host Microbe. 2019;25(1):87–e100110.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ventura JD, Beloor J, Allen E, Zhang T, Haugh KA, Uchil PD, Ochsenbauer C, Kieffer C, Kumar P, Hope TJ, et al. Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice. PLoS Pathog. 2019;15(12):e1008161.

Article  PubMed  PubMed Central  Google Scholar 

Haugh KA, Ladinsky MS, Ullah I, Stone HM, Pi R, Gilardet A, Grunst MW, Kumar P, Bjorkman PJ, Mothes W et al. In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission. Elife. 2021;10.

Uchil PD, Haugh KA, Pi R, Mothes W. In vivo imaging-driven approaches to study virus dissemination and pathogenesis. Annu Rev Virol. 2019;6(1):501–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ullah I, Prevost J, Ladinsky MS, Stone H, Lu M, Anand SP, Beaudoin-Bussieres G, Symmes K, Benlarbi M, Ding S, et al. Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require fc function for optimal efficacy. Immunity. 2021;54(9):2143–e21582115.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ullah I, Beaudoin-Bussieres G, Symmes K, Cloutier M, Ducas E, Tauzin A, Laumaea A, Grunst MW, Dionne K, Richard J, et al. The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice. Cell Rep Med. 2023;4(1):100893.

Article  CAS 

留言 (0)

沒有登入
gif