United Nations, World Population Ageing 2019: Highlights. https://www.un.org/en/development/desa/po-pulation/publications/pdf/ageing/.

Dzau, V.J., Inouye, S.K., Rowe, J.W., Finkelman, E., and Yamada, T., Enabling healthful aging for all—the National Academy of Medicine grand challenge in healthy longevity, N. Engl. J. Med., 2019, vol. 381, pp. 1699–1701. https://doi.org/10.1056/NEJMp1912298

Article  PubMed  Google Scholar 

Tkacheva, O.N., Kotovskaya, Yu.V., Runikhina, N.K., Frolova, E.V., Naumov, A.V., Vorob’eva, N.M., Ostapenko, V.S., Mkhitaryan, E.A., Sharashkina, N.V., Tyukhmenev, E.A., Pereverzev, A.P., and Dudinskaya, E.N., “Frailty” clinical recommendations, Ross. Zh. Geriatr. Med., 2020, no. 1, pp. 11–46.

Tkacheva, O.N., Kotovskaya, Yu.V., Runikhina, N.K., Frolova, E.V., Naumov, A.V., Vorob’eva, N.M., Ostapenko, V.S., Mkhitaryan, E.A., Sharashkina, N.V., Tyukhmenev, E.A., Pereverzev, A.P., and Dudinskaya, E.N., “Frailty” clinical recommendations. Part 2, Ross. Zh. Geriatr. Med., 2020, no. 2, pp. 115–130. https://doi.org/10.37586/2686-8636-2-2020-115-130

Lorenzi, M., Bonassi, S., Lorenzi, T., Giovannini, S., Bernabei, R., and Onder, G., A review of telomere length in sarcopenia and frailty, Biogerontol., 2018, vol. 19, pp. 209–221. https://doi.org/10.1007/s10522-018-9749-5

Article  CAS  Google Scholar 

Fasching, C.L., Telomere length measurement as a clinical biomarker of aging and disease, Crit. Rev. Clin. Lab. Sci., 2018, vol. 55, pp. 443–465. https://doi.org/10.1080/10408363.2018.1504274

Article  CAS  PubMed  Google Scholar 

Rossiello, F., Jurk, D., Passos, J.F., et al., Telomere dysfunction in ageing and age-related diseases, Nat. Cell Biol., 2022, vol. 24, pp. 135–147. https://doi.org/10.1038/s41556-022-00842-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cawthon, R.M., Smith, K.R., O’Brien, E., Sivatchenko, A., and Kerber, R.A., Association between telomere length in blood and mortality in people aged 60 years or older, Lancet, 2003, vol. 361, pp. 393–395. https://doi.org/10.1016/S0140-6736(03)12384-7

Article  CAS  PubMed  Google Scholar 

El Assar, M., Angulo, J., and Rodríguez-Mañas, L., Frailty as a phenotypic manifestation of underlying oxidative stress, Free Radic. Biol. Med., 2020, vol. 149, pp. 72–77. https://doi.org/10.1016/j.freeradbiomed.2019.08.011

Article  CAS  PubMed  Google Scholar 

Araújo Carvalho, A.C., Tavares Mendes, M.L., da Silva Reis, M.C., Santos, V.S., Tanajura, D.M., and Martins-Filho, P.R.S., Telomere length and frailty in older adults—A systematic review and meta-analysis, Ageing Res. Rev., 2019, vol. 54, p. 100914. https://doi.org/10.1016/j.arr.2019.100914

Article  CAS  PubMed  Google Scholar 

Sharashkina, N.V., Tkacheva, O.N., Runikhina, N.K., Aref’eva, M.S., Eruslanova, K.A., Ostapenko, V.S., and Kotovskaya, Yu.V., Comprehensive geriatric assessment is the main instrument of geriatrician’s work, Ross. Zh. Geriatr. Med., 2022, no. 4, pp. 210–227. https://doi.org/10.37586/2686-8636-4-2022-210-227

Muezzinler, A., Zaineddin, A.K., and Brenner, H.A., Systematic review of leukocyte telomere length and age in adults, Ageing Res. Rev., 2013, vol. 12, pp. 509–519. https://doi.org/10.1016/j.arr.2013.01.003

Article  CAS  PubMed  Google Scholar 

Blackburn, E.H., Epel, E.S., and Lin, J., Human telomere biology: A contributory and interactive factor in aging, disease risk, and protection, Science, 2015, vol. 350, pp. 1193–1198. https://doi.org/10.1126/science.aab3389

Article  ADS  CAS  PubMed  Google Scholar 

Cawthon, R.M., Smith, K.R., O’Brien, E., Sivatchenko, A., and Kerber, R.A., Association between telomere length in blood and mortality in people aged 60 years or older, Lancet, 2003, vol. 361, pp. 393–395. https://doi.org/10.1016/S0140-6736(03)12384-7

Article  CAS  PubMed  Google Scholar 

Svensson, J., Karlsson, M.K., Ljunggren, O., Tivesten, A., Mellstrom, D., and Moverare-Skrtic, S., Leukocyte telomere length is not associated with mortality in older men. Exp. Gerontol., 2014, vol. 57, pp. 6–12. https://doi.org/10.1016/j.exger.2014.04.013

Article  CAS  PubMed  Google Scholar 

Needham, B.L., Rehkopf, D., Adler, N., Gregorich, S., Lin, J., Blackburn, E.H., and Epel, E.S., Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999–2002, Epidemiology, 2015, vol. 26, pp. 528–535. https://doi.org/10.1097/EDE.0000000000000299

Article  PubMed  PubMed Central  Google Scholar 

Woo, J., Yu, R., Tang, N., and Leung, J., Telomere length is associated with decline in grip strength in older persons aged 65 years and over, Age (Dordr.), 2014, vol. 36, p. 9711.https://doi.org/10.1007/s11357-014-9711-7

El Assar, M., Angulo, J., Carnicero, J.A., et al., Association between telomere length, frailty and death in older adults, Geroscience, 2021, vol. 43, no. 2, pp. 1015–1027. https://doi.org/10.1007/s11357-020-00291-0

Article  CAS  PubMed  Google Scholar 

Wang, Q., Zhan, Y., Pedersen, N.L., Fang, F., and Hagg, S., Telomere length and all-cause mortality: A meta-analysis, Ageing Res. Rev., 2018, vol. 48, pp. 11–20. https://doi.org/10.1016/j.arr.2018.09.002

Article  CAS  PubMed  Google Scholar 

Zhan, Y., Liu, X.R., Reynolds, C.A., Pedersen, N.L., Hagg, S., and Clements, M.S., Leukocyte telomere length and all-cause mortality: A between–within twin study with time-dependent effects using generalized survival models, Am. J. Epidemiol., 2018, vol. 187, pp. 2186–2191. https://doi.org/10.1093/aje/kwy128

Article  PubMed  Google Scholar 

Martin-Ruiz, C.M., Gussekloo, J., van Heemst, D., von Zglinicki, T., and Westendorp, R.G., Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: A population-based study, Aging Cell, 2005, vol. 4, pp. 287–290. https://doi.org/10.1111/j.1474-9726.2005.00171.x

Article  CAS  PubMed  Google Scholar 

Rodríguez-Manas, L., Féart, C., Mann, G., et al., FOD-CC group (Appendix 1) Searching for an operational definition of frailty: A Delphi method based consensus statement: The frailty operative definition-consensus conference project, J. Gerontol. A Biol. Sci. Med. Sci., 2013, vol. 68, pp. 62–67. https://doi.org/10.1093/gerona/gls11

Article  PubMed  Google Scholar 

Cawthon, R.M., Telomere measurement by quantitative PCR, Nucleic Acids Res., 2002, vol. 30, no. 10, p. e47.

Article  PubMed  PubMed Central  Google Scholar 

Strazhesko, I., Tkacheva, O., Boytsov, S., et al., Association of insulin resistance, arterial stiffness and telomere length in adults free of cardiovascular diseases, PLoS One, 2015, vol. 10, no. 8, p. e0136676.

Article  PubMed  PubMed Central  Google Scholar 

Dagnall, C.L., Hicks, B., Teshome, K., Hutchinson, A.A., Gadalla, S.M., Khincha, P.P., Yeager, M., and Savage, S.A., Effect of pre-analytic variables on the reproducibility of qPCR relative telomere length measurement, PLoS One, 2017, vol. 12, no. 9, p. e0184098.

Article  PubMed  PubMed Central  Google Scholar