Multi-component reactions (MCRs) are processes in which three or more reactants are introduced in one pot to deliver final product with high atom efficiency, and in recent years those have become a key strategy for advancing more sustainable processes in modern synthetic communities and the pharmaceutical industry. Meanwhile, minimizing the use of solvents, catalysts, time, reagents, and waste is essential during the green chemical synthesis to reduce cost and environmental impact. Heterocycles are ubiquitous and have thus aroused numerous methods to synthesize them. Among various strategy, MCR is one of the most promising routes for the synthesis of heterocyclic moiety such as quinolines, quinazolines, pyrimidines and imidazoles, which are widely recognized in nature and clinical evaluation. To go towards greener syntheses, a majority of literatures exists to accomplish the synthesis of these biologically important compounds via environmentally friendly MCRs. This review focused on the recent advances in the green approach toward heterocyclic compounds via MCRs. These green approaches included photoredox catalysis, electrochemical activation, catalyst free as well as water as solo green solvent, reported between 2018 and 2024, highlighting their strength and limitation. Synthesis of different types of heterocycles via green MCRs was covered. The scope of substrate, reaction conditions, yields as well as mechanism were also examined and discussed.