Abdel-Haq R, Schlachetzki JCM, Glass CK, Mazmanian SK (2019) Microbiome-microglia connections via the gut-brain axis. J Exp Med 216:41–59

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anderson JR, Carroll I, Azcarate-Peril MA, Rochette AD, Heinberg LJ, Peat C, Steffen K, Manderino LM, Mitchell J, Gunstad J (2017) A preliminary examination of gut microbiota, sleep, and cognitive flexibility in healthy older adults. Sleep Med 38:104–107

Article  PubMed  PubMed Central  Google Scholar 

Becken B, Davey L, Middleton DR, Mueller KD, Sharma A, Holmes ZC, Dallow E, Remick B, Barton GM, David LA, McCann JR, Armstrong SC, Malkus P, Valdivia RH (2021) Genotypic and Phenotypic Diversity among Human Isolates of Akkermansia muciniphila. MBio 12

Benakis C, Martin-Gallausiaux C, Trezzi J-P, Melton P, Liesz A, Wilmes P (2020) The microbiome-gut-brain axis in acute and chronic brain diseases. Curr Opin Neurobiol 61:1–9

Article  CAS  PubMed  Google Scholar 

Bodogai M et al (2018) Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells. Sci Transl Med 10

Cai W, Dai X, Chen J, Zhao J, Xu M, Zhang L, Yang B, Zhang W, Rocha M, Nakao T, Kofler J, Shi Y, Stetler RA, Hu X, Chen J (2019) STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice. JCI insight 4

Cani PD, Depommier C, Derrien M, Everard A, de Vos WM (2022) Author correction: Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms. Nat Rev Gastroenterol Hepatol 19:682

Article  PubMed  Google Scholar 

Carranza-Naval MJ, Vargas-Soria M, Hierro-Bujalance C, Baena-Nieto G, Garcia-Alloza M, Infante-Garcia C, Del Marco A (2021) Alzheimer’s Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models. Biomolecules 11

Chakrabarti A, Geurts L, Hoyles L, Iozzo P, Kraneveld AD, La Fata G, Miani M, Patterson E, Pot B, Shortt C, Vauzour D (2022) The microbiota-gut-brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice. Cell Mol Life Sci 79:80

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang Y, Woo HG, Jeong JH, Kim GH, Park KD, Song T-J (2021) Microbiota dysbiosis and functional outcome in acute ischemic stroke patients. Sci Rep 11:10977

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen R, Xu Y, Wu P, Zhou H, Lasanajak Y, Fang Y, Tang L, Ye L, Li X, Cai Z, Zhao J (2019) Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota. Pharmacol Res 148:104403

Article  CAS  PubMed  Google Scholar 

Chen C, Liao J, Xia Y, Liu X, Jones R, Haran J, McCormick B, Sampson TR, Alam A, Ye K (2022) Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation. Gut 71:2233–2252

Article  PubMed  Google Scholar 

Choi KM, Kashyap PC, Dutta N, Stoltz GJ, Ordog T, Shea Donohue T, Bauer AJ, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G (2010) CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice. Gastroenterology 138:2399–2409 2409.e1

Article  CAS  PubMed  Google Scholar 

Cryan JF et al (2019) The Microbiota-Gut-Brain Axis. Physiol Rev 99:1877–2013

Article  CAS  PubMed  Google Scholar 

Ding Y, Bu F, Chen T, Shi G, Yuan X, Feng Z, Duan Z, Wang R, Zhang S, Wang Q, Zhou J, Chen Y (2021) A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress-induced depressive-like behavior in mice by regulating gut microbiota and metabolites. Appl Microbiol Biotechnol 105:8411–8426

Article  CAS  PubMed  Google Scholar 

Dooling SW, Costa-Mattioli M (2018) Gut Bacteria seize control of the brain to prevent Epilepsy. Cell Host Microbe 24:3–5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Endres M, Moro MA, Nolte CH, Dames C, Buckwalter MS, Meisel A (2022) Immune pathways in Etiology, Acute Phase, and chronic sequelae of ischemic stroke. Circ Res 130:1167–1186

Article  CAS  PubMed  Google Scholar 

Erny D et al (2015) Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci 18:965–977

Article  CAS  PubMed  PubMed Central  Google Scholar 

Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A 110:9066–9071

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Q, Han Z-Y, Tian D-F, Liu G-L, Wang Z-Y, Lin J-F, Chang Z, Zhang D-D, Xie Y-Z, Sun Y-K, Yao X-W, Ma D-Y (2021) Xinglou Chengqi decoction improves neurological function in experimental stroke mice as evidenced by gut microbiota analysis and network pharmacology. Chin J Nat Med 19:881–899

CAS  PubMed  Google Scholar 

Ghotaslou R, Nabizadeh E, Memar MY, Law WMH, Ozma MA, Abdi M, Yekani M, Kadkhoda H, Hosseinpour R, Bafadam S, Ghotaslou A, Leylabadlo HE, Nezhadi J (2023) The metabolic, protective, and immune functions of Akkermansia muciniphila. Microbiol Res 266:127245

Article  CAS  PubMed  Google Scholar 

Gotkine M, Kviatcovsky D, Elinav E (2020) Amyotrophic lateral sclerosis and intestinal microbiota-toward establishing cause and effect. Gut Microbes 11:1833–1841

Article  PubMed  PubMed Central  Google Scholar 

Hediyal TA, Vichitra C, Anand N, Bhaskaran M, Essa SM, Kumar P, Qoronfleh MW, Akbar M, Kaul-Ghanekar R, Mahalakshmi AM, Yang J, Song B-J, Monaghan TM, Sakharkar MK, Chidambaram SB (2024) Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update. Front Immunol 15:1324018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Honarpisheh P, Bryan RM, McCullough LD (2022) Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome. Circ Res 130:1112–1144

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu X, Wang T, Jin F (2016) Alzheimer’s disease and gut microbiota. Sci China Life Sci 59:1006–1023

Article  CAS  PubMed  Google Scholar 

Hua Q, Han Y, Zhao H, Zhang H, Yan B, Pei S, He X, Li Y, Meng X, Chen L, Zhong F, Li D (2022) Punicalagin alleviates renal injury via the gut-kidney axis in high-fat diet-induced diabetic mice. Food Funct 13:867–879

Article  CAS  PubMed  Google Scholar 

Huang S, Hu S, Liu S, Tang B, Liu Y, Tang L, Lei Y, Zhong L, Yang S, He S (2022) Lithium carbonate alleviates colon inflammation through modulating gut microbiota and Treg cells in a GPR43-dependent manner. Pharmacol Res 175:105992

Article  CAS  PubMed  Google Scholar 

Jeon J, Lourenco J, Kaiser EE, Waters ES, Scheulin KM, Fang X, Kinder HA, Platt SR, Rothrock MJJ, Callaway TR, West FD, Park HJ (2020) Dynamic changes in the gut microbiome at the Acute Stage of ischemic stroke in a Pig Model. Front Neurosci 14:587986

Article  PubMed  PubMed Central  Google Scholar 

Ju F, Ran Y, Zhu L, Cheng X, Gao H, Xi X, Yang Z, Zhang S (2018) Increased BBB permeability enhances activation of microglia and exacerbates loss of dendritic spines after transient global cerebral ischemia. Front Cell Neurosci 12:1–14

Article  Google Scholar 

Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, Littman DR (2000) Analysis of Fractalkine receptor CX 3 CR1 function by targeted deletion and green fluorescent protein reporter Gene Insertion. Mol Cell Biol 20:4106–4114

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim M-S, Kim Y, Choi H, Kim W, Park S, Lee D, Kim DK, Kim HJ, Choi H, Hyun D-W, Lee J-Y, Choi EY, Lee D-S, Bae J-W, Mook-Jung I (2020) Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model. Gut 69:283–294

Article  CAS  PubMed  Google Scholar 

Kim S-M et al (2023) Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis. Cell Host Microbe 31:1021–1037e10

Article  CAS  PubMed