Risk Reduction of Cognitive Decline and Dementia: WHO Guidelines. Geneva: World Health Organization; 2019. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542796/.

Ramanan VK, Day GS. Anti-amyloid therapies for Alzheimer disease: finally, good news for patients. Mol Neurodegener. 2023;18(1):42.

Article  PubMed  PubMed Central  Google Scholar 

Kivipelto M, Mangialasche F, Ngandu T. Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol. 2018;14(11):653–66.

Article  PubMed  Google Scholar 

Livingston G, Huntley J, Liu KY, Costafreda SG, Selbæk G, Alladi S, et al. Dementia prevention, intervention, and care: 2024 report of the lancet standing commission. Lancet. 2024;404(10452):572–628.

Article  PubMed  Google Scholar 

Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the lancet commission. Lancet. 2020;396(10248):413–46.

Article  PubMed  PubMed Central  Google Scholar 

Almeida OP, Hankey GJ, Yeap BB, Golledge J, Flicker L. Depression as a modifiable factor to decrease the risk of dementia. Transl Psychiatry. 2017;7(5):e1117.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bjelik A, Bereczki E, Gonda S, Juhász A, Rimanóczy A, Zana M, et al. Human apoB overexpression and a high-cholesterol diet differently modify the brain APP metabolism in the transgenic mouse model of atherosclerosis. Neurochem Int. 2006;49(4):393–400.

Article  PubMed  CAS  Google Scholar 

Chung JK, Plitman E, Nakajima S, Chow TW, Chakravarty MM, Caravaggio F, et al. Lifetime history of depression predicts increased Amyloid-β accumulation in patients with mild cognitive impairment. J Alzheimers Dis. 2015;45(3):907–19.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dong JY, Zhang YH, Tong J, Qin LQ. Depression and risk of stroke: a meta-analysis of prospective studies. Stroke. 2012;43(1):32–7.

Article  PubMed  Google Scholar 

Donovan NJ, Locascio JJ, Marshall GA, Gatchel J, Hanseeuw BJ, Rentz DM, et al. Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults. Am J Psychiatry. 2018;175(6):530–7.

Article  PubMed  PubMed Central  Google Scholar 

Durazzo TC, Mattsson N, Weiner MW. Smoking and increased Alzheimer’s disease risk: a review of potential mechanisms. Alzheimers Dement. 2014;10(3 Suppl):S122–45.

PubMed  Google Scholar 

Goldstein-Piekarski AN, Williams LM, Humphreys K. A trans-diagnostic review of anxiety disorder comorbidity and the impact of multiple exclusion criteria on studying clinical outcomes in anxiety disorders. Transl Psychiatry. 2016;6(6):e847.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Harrington KD, Gould E, Lim YY, Ames D, Pietrzak RH, Rembach A, et al. Amyloid burden and incident depressive symptoms in cognitively normal older adults. Int J Geriatr Psychiatry. 2017;32(4):455–63.

Article  PubMed  Google Scholar 

Johnson AL, Nystrom NC, Piper ME, Cook J, Norton DL, Zuelsdorff M, et al. Cigarette smoking status, cigarette exposure, and duration of abstinence predicting incident dementia and death: a multistate model approach. J Alzheimers Dis. 2021;80(3):1013–23.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Peters R, Poulter R, Warner J, Beckett N, Burch L, Bulpitt C. Smoking, dementia and cognitive decline in the elderly, a systematic review. BMC Geriatr. 2008;8:36.

Article  PubMed  PubMed Central  Google Scholar 

Sabia S, Elbaz A, Dugravot A, Head J, Shipley M, Hagger-Johnson G, et al. Impact of smoking on cognitive decline in early old age: the Whitehall II cohort study. Arch Gen Psychiatry. 2012;69(6):627–35.

Article  PubMed  PubMed Central  Google Scholar 

Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol. 2006;5(9):735–41.

Article  PubMed  Google Scholar 

Gabin JM, Tambs K, Saltvedt I, Sund E, Holmen J. Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study. Alzheimers Res Ther. 2017;9(1):37.

Article  PubMed  PubMed Central  Google Scholar 

Li JQ, Tan L, Wang HF, Tan MS, Tan L, Xu W, et al. Risk factors for predicting progression from mild cognitive impairment to Alzheimer’s disease: a systematic review and meta-analysis of cohort studies. J Neurol Neurosurg Psychiatry. 2016;87(5):476–84.

Article  PubMed  Google Scholar 

Arnoldussen IA, Kiliaan AJ, Gustafson DR. Obesity and dementia: adipokines interact with the brain. Eur Neuropsychopharmacol. 2014;24(12):1982–99.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Walker KA, Power MC, Gottesman RF. Defining the Relationship between hypertension, cognitive decline, and dementia: a review. Curr Hypertens Rep. 2017;19(3):24.

Article  PubMed  PubMed Central  Google Scholar 

Solomon A, Stephen R, Altomare D, Carrera E, Frisoni GB, Kulmala J, et al. Multidomain interventions: state-of-the-art and future directions for protocols to implement precision dementia risk reduction. A user manual for Brain Health Services-part 4 of 6. Alzheimers Res Ther. 2021;13(1):171.

Article  PubMed  PubMed Central  Google Scholar 

Enache D, Solomon A, Cavallin L, Kåreholt I, Kramberger MG, Aarsland D, et al. CAIDE Dementia risk score and biomarkers of neurodegeneration in memory clinic patients without dementia. Neurobiol Aging. 2016;42:124–31.

Article  PubMed  CAS  Google Scholar 

Hooshmand B, Polvikoski T, Kivipelto M, Tanskanen M, Myllykangas L, Mäkelä M, et al. CAIDE Dementia risk score, Alzheimer and cerebrovascular pathology: a population-based autopsy study. J Intern Med. 2018;283(6):597–603.

Article  PubMed  CAS  Google Scholar 

O’Brien JT, Firbank MJ, Ritchie K, Wells K, Williams GB, Ritchie CW, et al. Association between midlife dementia risk factors and longitudinal brain atrophy: the PREVENT-Dementia study. J Neurol Neurosurg Psychiatry. 2020;91(2):158–61.

Article  PubMed  Google Scholar 

Stephen R, Liu Y, Ngandu T, Rinne JO, Kemppainen N, Parkkola R, et al. Associations of CAIDE Dementia risk score with MRI, PIB-PET measures, and cognition. J Alzheimers Dis. 2017;59(2):695–705.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vuorinen M, Spulber G, Damangir S, Niskanen E, Ngandu T, Soininen H, et al. Midlife CAIDE dementia risk score and dementia-related brain changes up to 30 years later on magnetic resonance imaging. J Alzheimers Dis. 2015;44(1):93–101.

Article  PubMed  CAS  Google Scholar 

Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385(9984):2255–63.

Article  PubMed  Google Scholar 

Chhetri JK, de Souto BP, Cantet C, Pothier K, Cesari M, Andrieu S, et al. Effects of a 3-Year multi-domain intervention with or without omega-3 supplementation on cognitive functions in older subjects with increased CAIDE Dementia Scores. J Alzheimers Dis. 2018;64(1):71–8.

Article  PubMed  CAS  Google Scholar 

Ockene IS, Miller NH. Cigarette smoking, cardiovascular disease, and stroke: a statement for healthcare professionals from the American heart association. . American heart association task force on risk reduction. Circulation. 1997;96(9):3243–7.

Article  PubMed  CAS  Google Scholar 

National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. Atlanta: Centers for Disease Control and Prevention (US); 2014.

Almeida OP, Garrido GJ, Lautenschlager NT, Hulse GK, Jamrozik K, Flicker L. Smoking is associated with reduced cortical regional gray matter density in brain regions associated with incipient Alzheimer disease. Am J Geriatr Psychiatry. 2008;16(1):92–8.

Article