Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M. Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics. Int J Nanomedicine. 2019;14:5541.
Article CAS PubMed PubMed Central Google Scholar
Alzheimer’s Disease International (ADI), https://www.alzint.org/about/dementia-facts-figures/dementia-statistics/ (access on 24/1/2024).
Plascencia-Villa G, Perry G. Preventive and therapeutic strategies in Alzheimer’s disease: focus on oxidative stress, redox metals, and ferroptosis. Antioxid Redox Signal. 2021;34:591–610.
Article CAS PubMed PubMed Central Google Scholar
Tatulian SA. Challenges and hopes for Alzheimer’s disease. Drug Discov Today. 2022;27:1027–43.
Athar T, Al Balushi K, Khan SA. Recent advances on drug development and emerging therapeutic agents for Alzheimer’s disease. Mol Biol Rep. 2021;48:5629–45.
Article CAS PubMed PubMed Central Google Scholar
Shi R, Wu Q, Xin C, Yu H, Lim KL, Li X, et al. Structure-based specific detection and inhibition of monoamine oxidases and their applications in central nervous system diseases. Chembiochem. 2019;20:1487–97.
Article CAS PubMed Google Scholar
Bortolato M, Shih JC. Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence. Int Rev Neurobiol. 2011;100:13–42.
Article PubMed PubMed Central Google Scholar
Xie SS, Liu J, Tang C, Pang C, Li Q, Qin Y, et al. Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer’s disease. Eur J Med Chem. 2020;202:112475.
Article CAS PubMed Google Scholar
Lu C, Zhou Q, Yan J, Du Z, Huang L, Li X, et al. A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer’s disease. Eur J Med Chem. 2013;62:745–53.
Article CAS PubMed Google Scholar
Sies H. Role of metabolic H2O2 generation: redox signaling and oxidative stress. J Biol Chem. 2014;289:8735–41.
Article CAS PubMed PubMed Central Google Scholar
Mertens MD, Hinz S, Müller CE, Gütschow M, et al. Alkynyl-coumarinyl ethers as MAO-B inhibitors. Bioorg Med Chem. 2014;22:1916–28.
Article CAS PubMed Google Scholar
Tripathi RKP, Ayyannan SR. Monoamine oxidase-B inhibitors as potential neurotherapeutic agents: an overview and update. Med Res Rev. 2019;39:1603–706.
Article CAS PubMed Google Scholar
Thomas T. Monoamine oxidase-B inhibitors in the treatment of Alzheimer’s disease. Neurobiol Aging. 2000;21:343–8.
Article CAS PubMed Google Scholar
Chen GF, Xu TH, Yan Y, Zhou YR, Jiang Y, Melcher K, et al. Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacol Sin. 2017;38:1205–35.
Article CAS PubMed PubMed Central Google Scholar
Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, et al. The amyloid-β pathway in Alzheimer’s disease. Mol Psychiatry. 2021;26:5481–503.
Article CAS PubMed PubMed Central Google Scholar
Wang Q, Yu X, Li L, Zheng J, et al. Inhibition of amyloid-β aggregation in Alzheimer’s disease. Curr Pharm Des. 2014;20:1223–43.
Goyal D, Shuaib S, Mann S, Goyal B, et al. Rationally designed peptides and peptidomimetics as inhibitors of amyloid-β (Aβ) aggregation: potential therapeutics of Alzheimer’s disease. ACS Comb Sci. 2017;19:55–80.
Article CAS PubMed Google Scholar
Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, et al. The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease. Nature. 2016;537:50–6.
Article CAS PubMed Google Scholar
Albertini C, Salerno A, de Sena Murteira Pinheiro P, Bolognesi ML, et al. From combinations to multitarget-directed ligands: a continuum in Alzheimer’s disease polypharmacology. Med Res Rev. 2021;41:2606–33.
Ramalakshmi N, R SR, C NN. Multitarget directed ligand approaches for Alzheimer’s disease: a comprehensive review. Mini Rev Med Chem. 2021;21:2361–88.
Article CAS PubMed Google Scholar
Michalska P, Buendia I, Del Barrio L, Leon R, et al. Novel multitarget hybrid compounds for the treatment of Alzheimer’s disease. Curr Top Med Chem. 2017;17:1027–43.
Article CAS PubMed Google Scholar
Li JC, Zhang J, Rodrigues MC, Ding DJ, Longo JP, Azevedo RB, et al. Synthesis and evaluation of novel 1,2,3-triazole-based acetylcholinesterase inhibitors with neuroprotective activity. Bioorg Med Chem Lett. 2016;26:3881–5.
Article CAS PubMed Google Scholar
Zhang J, Li JC, Song JL, Cheng ZQ, Sun JZ, Jiang CS, et al. Synthesis and evaluation of coumarin/1,2,4-oxadiazole hybrids as selective BChE inhibitors with neuroprotective activity. J Asian Nat Prod Res. 2019;21:1090–103.
Article CAS PubMed Google Scholar
Jiang CS, Ge YX, Cheng ZQ, Wang YY, Tao HR, Zhu K, et al. Discovery of new selective butyrylcholinesterase (BChE) inhibitors with anti-Aβ aggregation activity: structure-based virtual screening, hit optimization and biological evaluation. Molecules. 2019;24:2568.
Article CAS PubMed PubMed Central Google Scholar
Cheng ZQ, Zhu KK, Zhang J, Song JL, Muehlmann LA, Jiang CS, et al. Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors. Bioorg Chem. 2019;83:277–88.
Article CAS PubMed Google Scholar
Cheng ZQ, Song JL, Zhu K, Zhang J, Jiang CS, Zhang H, et al. Total synthesis of pulmonarin B and design of brominated phenylacetic acid/tacrine hybrids: marine pharmacophore inspired discovery of new ChE and Aβ aggregation inhibitors. Mar Drugs. 2018;16:293.
Article PubMed PubMed Central Google Scholar
Jiang CS, Ge YX, Cheng ZQ, Song JL, Wang YY, Zhu K, et al. Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation. J Comput Aided Mol Des. 2019;33:521–30.
Article CAS PubMed Google Scholar
Manzoor S, Hoda N. A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer’s disease agents: a review. Eur J Med Chem. 2020;206:112787.
Article CAS PubMed Google Scholar
Košak U, Strašek N, Knez D, Jukič M, Žakelj S, Zahirović A, et al. N-alkylpiperidine carbamates as potential anti-Alzheimer’s agents. Eur J Med Chem. 2020;197:112282.
Huang M, Xie SS, Jiang N, Lan JS, Kong LY, Wang XB. Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer’s disease. Bioorg Med Chem Lett. 2015;25:508–13.
Article CAS PubMed Google Scholar
Newman DJ, Cragg GM. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J Nat Prod. 2020;83:770–803.
留言 (0)