Cooperative interactions between neurotrophin receptors and CXCR4 regulate macrophage phenotype and susceptibility to activation by HIV

Akekawatchai C, Holland JD, Kochetkova M, Wallace JC, McColl SR (2005) Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells. J Biol Chem 280(48):39701–39708

Article  CAS  PubMed  Google Scholar 

Busillo JM, Benovic JL (2007) Regulation of CXCR4 signaling. Biochim Biophys Acta 1768(4):952–963

Article  CAS  PubMed  Google Scholar 

Cheung R, Ravyn V, Wang L, Ptasznik A, Collman RG (2008) Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages. J Immunol 180(10):6675–6684

Article  CAS  PubMed  Google Scholar 

Davis CB, Dikic I, Unutmaz D, Hill CM, Arthos J, Siani MA, Thompson DA, Schlessinger J, Littman DR (1997) Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J Exp Med 186(10):1793–1798

Article  CAS  PubMed  PubMed Central  Google Scholar 

Del Corno M, Liu QH, Schols D, de Clercq E, Gessani S, Freedman BD, Collman RG (2001) HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling. Blood 98(10):2909–2916

Article  PubMed  Google Scholar 

Diaz GA (2005) CXCR4 mutations in WHIM syndrome: a misguided immune system? Immunol Rev 203:235–243

Article  CAS  PubMed  Google Scholar 

Domeniconi M, Chao MV (2010) Transactivation of trk receptors in spinal motor neurons. Histol Histopathol 25(9):1207–1213

CAS  PubMed  Google Scholar 

Duong LT, Rodan GA (2000) PYK2 is an adhesion kinase in macrophages, localized in podosomes and activated by beta(2)-integrin ligation. Cell Motil Cytoskeleton 47(3):174–188

Article  CAS  PubMed  Google Scholar 

Evans JG, Matsudaira P (2006) Structure and dynamics of macrophage podosomes. Eur J Cell Biol 85(3–4):145–149

Article  CAS  PubMed  Google Scholar 

Freedman BD, Liu QH, Corno MD, Collman RG (2003) HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages. Immunol Res 27(2–3):261–276

Article  CAS  PubMed  Google Scholar 

Garaci E, Caroleo MC, Aloe L, Aquaro S, Piacentini M, Costa N, Amendola A, Micera A, Calio R, Perno CF, Levi-Montalcini R (1999) Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV. Proc Natl Acad Sci USA 96(24):14013–14018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gil-Henn H, Destaing O, Sims NA, Aoki K, Alles N, Neff L, Sanjay A, Bruzzaniti A, De Camilli P, Baron R, Schlessinger J (2007) Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol 178(6):1053–1064

Article  CAS  PubMed  PubMed Central  Google Scholar 

Glass J, Wesselingh S, Selnes O, McArthur J (1993) Clincal-neuropathologic correlation in HIV-associated dementia. Neurology 43(11):2230–2237

Article  CAS  PubMed  Google Scholar 

Glass JD, Fedor H, Wesselingh SL, McArthur JC (1995) Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 38:755–762

Article  CAS  PubMed  Google Scholar 

Harrold SM, Dragic JM, Brown SL, Achim CL (2001) Neurotrophic factor regulation of human immunodeficiency virus type 1 replication in human blood-derived macrophages through modulation of coreceptor expression. Adv Exp Med Biol 493:41–47

Article  CAS  PubMed  Google Scholar 

Kaul M, Ma Q, Medders KE, Desai MK, Lipton SA (2007) HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ 14(2):296–305

Article  CAS  PubMed  Google Scholar 

Korvers L, de Andrade Costa A, Mersch M, Matyash V, Kettenmann H, Semtner M (2016) Spontaneous ca(2+) transients in mouse microglia. Cell Calcium 60(6):396–406

Article  CAS  PubMed  Google Scholar 

Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (2003) Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. J Leukoc Biol 74(5):676–682

Article  CAS  PubMed  Google Scholar 

Linder S, Wiesner C (2015) Tools of the trade: podosomes as multipurpose organelles of monocytic cells. Cell Mol Life Sci 72(1):121–135

Article  CAS  PubMed  Google Scholar 

Lipton S (1992) Requirement of macrophages in neuronal injury induced by HIV envelope protein gp120. NeuroReport. 3(10):913–915

Liu HY, Soda Y, Shimizu N, Haraguchi Y, Jinno A, Takeuchi Y, Hoshino H (2000a) CD4-Dependent and CD4-independent utilization of coreceptors by human immunodeficiency viruses type 2 and simian immunodeficiency viruses. Virology 278(1):276–288

Article  CAS  PubMed  Google Scholar 

Liu QH, Williams DA, McManus C, Baribaud F, Doms RW, Schols D, De Clercq E, Kotlikoff MI, Collman RG, Freedman BD (2000b) HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. Proc Natl Acad Sci USA 97(9):4832–4837

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maung R, Hoefer MM, Sanchez AB, Sejbuk NE, Medders KE, Desai MK, Catalan IC, Dowling CC, de Rozieres CM, Garden GA, Russo R, Roberts AJ, Williams R, Kaul M (2014) CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120. J Immunol 193(4):1895–1910

Article  CAS  PubMed  Google Scholar 

McNiven MA, Baldassarre M, Buccione R (2004) The role of dynamin in the assembly and function of podosomes and invadopodia. Front Bioscience: J Virtual Libr 9:1944–1953

Article  CAS  Google Scholar 

Meeker RB, Poulton W, Clary G, Schriver M, Longo FM (2016) Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis. Experimental Neurol 275 Pt 1:182–198

Article  Google Scholar 

Murphy DA, Courtneidge SA (2011) The ‘ins’ and ‘outs’ of podosomes and invadopodia: characteristics, formation and function. Nature reviews. Mol cell Biology 12(7):413–426

CAS  Google Scholar 

Pfaff M, Jurdic P (2001) Podosomes in osteoclast-like cells: structural analysis and cooperative roles of paxillin, proline-rich tyrosine kinase 2 (Pyk2) and integrin alphaVbeta3. J Cell Sci 114(Pt 15):2775–2786

Article  CAS  PubMed  Google Scholar 

Pyne NJ, Waters C, Moughal NA, Sambi B, Connell M, Pyne S (2004) Experimental systems for studying the role of G-protein-coupled receptors in receptor tyrosine kinase signal transduction. Methods Enzymol 390:451–475

Article  CAS  PubMed  Google Scholar 

Ray BJ, Thomas K, Huang CS, Gutknecht MF, Botchwey EA, Bouton AH (2012) Regulation of osteoclast structure and function by FAK family kinases. J Leukoc Biol 92(5):1021–1028

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rossio JL, Esser MT, Suryanarayana K, Schneider DK, Bess JW Jr., Vasquez GM, Wiltrout TA, Chertova E, Grimes MK, Sattentau Q, Arthur LO, Henderson LE, Lifson JD (1998) Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins. J Virol 72(10):7992–8001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Samah B, Porcheray F, Gras G (2008) Neurotrophins modulate monocyte chemotaxis without affecting macrophage function. Clin Exp Immunol 151(3):476–486

Article  CAS  PubMed  PubMed Central  Google Scholar 

Samah B, Porcheray F, Dereuddre-Bosquet N, Gras G (2009) Nerve growth factor stimulation promotes CXCL-12 attraction of monocytes but decreases human immunodeficiency virus replication in attracted population. J Neurovirol 15(1):71–80

Article  CAS  PubMed  Google Scholar 

Siddiqui TA, Lively S, Vincent C, Schlichter LC (2012) Regulation of podosome formation, microglial migration and invasion by ca(2+)-signaling molecules expressed in podosomes. J Neuroinflamm 9:250

Article  CAS  Google Scholar 

Sturdevant CB, Joseph SB, Schnell G, Price RW, Swanstrom R, Spudich S (2015) Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection. PLoS Pathog 11(3):e1004720

Article  PubMed  PubMed Central  Google Scholar 

Vincent C, Siddiqui TA, Schlichter LC (2012) Podosomes in migrating microglia: components and matrix degradation. J Neuroinflamm 9:190

Article  CAS  Google Scholar 

Williams KS, Killebrew DA, Clary GP, Seawell JA, Meeker RB (2015) Differential regulation of macrophage phenotype by mature and pro-nerve growth factor. J Neuroimmunol 285:76–93

Article  CAS  PubMed  PubMed Central  Google Scholar 

Williams KS, Killebrew DA, Clary GP, Meeker RB (2016) Opposing effects of NGF and proNGF on HIV Induced Macrophage activation. J Neuroimmune Pharmacology: Official J Soc NeuroImmune Pharmacol 11(1):98–120

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