Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646–674. https://doi.org/10.1016/j.cell.2011.02.013

Article  CAS  PubMed  Google Scholar 

Liu ZL, Chen HH, Zheng LL, Sun LP, Shi L (2023) Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal Trans Target Ther 8(1):198. https://doi.org/10.1038/s41392-023-01460-1

Article  CAS  Google Scholar 

Meng MB, Zaorsky NG, Deng L, Wang HH, Chao J, Zhao LJ, Yuan ZY, Ping W (2015) Pericytes: a double-edged sword in cancer therapy. Future oncology (London, England) 11(1):169–179. https://doi.org/10.2217/fon.14.123

Article  CAS  PubMed  Google Scholar 

Nishida N, Yano H, Nishida T, Kamura T, Kojiro M (2006) Angiogenesis in cancer. Vascular health and risk management 2(3):213–219. https://doi.org/10.2147/vhrm.2006.2.3.213

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferland-McCollough D, Slater S, Richard J, Reni C, Mangialardi G (2017) Pericytes, an overlooked player in vascular pathobiology. Pharmacol Ther 171:30–42. https://doi.org/10.1016/j.pharmthera.2016.11.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baek SH, Maiorino E, Kim H, Glass K, Raby BA, Yuan K (2022) Single cell transcriptomic analysis reveals organ specific pericyte markers and identities. Front Cardiov Med 9:876591. https://doi.org/10.3389/fcvm.2022.876591

Article  CAS  Google Scholar 

Gallí M, Van Gool F, Rongvaux A, Andris F, Leo O (2010) The nicotinamide phosphoribosyltransferase: a molecular link between metabolism, inflammation, and cancer. Can Res 70(1):8–11. https://doi.org/10.1158/0008-5472.CAN-09-2465

Article  CAS  Google Scholar 

Grolla AA, Travelli C, Genazzani AA, Sethi JK (2016) Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine. Br J Pharmacol 173(14):2182–2194. https://doi.org/10.1111/bph.13505

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel ST, Mistry T, Brown JE, Digby JE, Adya R, Desai KM, Randeva HS (2010) A novel role for the adipokine visfatin/pre-B cell colony-enhancing factor 1 in prostate carcinogenesis. Peptides 31(1):51–57. https://doi.org/10.1016/j.peptides.2009.10.001

Article  CAS  PubMed  Google Scholar 

Grolla AA, Torretta S, Gnemmi I, Amoruso A, Orsomando G, Gatti M, Caldarelli A, Lim D, Penengo L, Brunelleschi S, Genazzani AA, Travelli C (2015) Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is a tumoural cytokine released from melanoma. Pigment Cell Melanoma Res 28(6):718–729. https://doi.org/10.1111/pcmr.12420

Article  CAS  PubMed  Google Scholar 

Audrito V (2020) The dual face of NAMPT: Intracellular/extracellular protein and diagnostic/therapeutic target in cancer. EBioMedicine 62:103109. https://doi.org/10.1016/j.ebiom.2020.103109

Article  CAS  PubMed  PubMed Central  Google Scholar 

Camp SM, Ceco E, Evenoski CL, Danilov SM, Zhou T, Chiang ET, Moreno-Vinasco L, Mapes B, Zhao J, Gursoy G, Brown ME, Adyshev DM, Siddiqui SS, Quijada H, Sammani S, Letsiou E, Saadat L, Yousef M, Wang T, Liang J, Garcia JG (2015) Unique Toll-like receptor 4 activation by NAMPT/PBEF induces NFκB signaling and inflammatory lung injury. Sci Rep. https://doi.org/10.1038/srep13135

Article  PubMed  PubMed Central  Google Scholar 

Managò A, Audrito V, Mazzola F, Sorci L, Gaudino F, Gizzi K, Vitale N, Incarnato D, Minazzato G, Ianniello A, Varriale A, D’Auria S, Mengozzi G, Politano G, Oliviero S, Raffaelli N, Deaglio S (2019) Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation. Nat Commun 10(1):4116. https://doi.org/10.1038/s41467-019-12055-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Torretta S, Colombo G, Travelli C, Boumya S, Lim D, Genazzani AA, Grolla AA (2020) The cytokine nicotinamide phosphoribosyltransferase (eNAMPT; PBEF; Visfatin) acts as a natural antagonist of C–C chemokine receptor type 5 (CCR5). Cells 9(2):496. https://doi.org/10.3390/cells9020496

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colombo G, Travelli C, Porta C, Genazzani AA (2022) Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4. iScience 25(4):104147. https://doi.org/10.1016/j.isci.2022.104147

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heske CM (2020) Beyond energy metabolism: exploiting the additional roles of NAMPT for cancer therapy. Front Oncol 9:1514. https://doi.org/10.3389/fonc.2019.01514

Article  PubMed  PubMed Central  Google Scholar 

Zhou SJ, Bi TQ, Qin CX, Yang XQ, Pang K (2018) Expression of NAMPT is associated with breast invasive ductal carcinoma development and prognosis. Oncol Lett 15(5):6648–6654. https://doi.org/10.3892/ol.2018.8164

Article  CAS  PubMed  PubMed Central  Google Scholar 

Soncini D, Caffa I, Zoppoli G, Cea M, Cagnetta A, Passalacqua M, Mastracci L, Boero S, Montecucco F, Sociali G, Lasigliè D, Damonte P, Grozio A, Mannino E, Poggi A, D’Agostino VG, Monacelli F, Provenzani A, Odetti P, Ballestrero A, Nencioni A (2014) Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity. J Biol Chem 289(49):34189–34204. https://doi.org/10.1074/jbc.M114.594721

Article  CAS  PubMed  PubMed Central  Google Scholar 

Assiri AM, Kamel HF (2016) Evaluation of diagnostic and predictive value of serum adipokines: leptin, resistin and visfatin in postmenopausal breast cancer. Obes Res Clin Pract 10(4):442–453. https://doi.org/10.1016/j.orcp.2015.08.017

Article  PubMed  Google Scholar 

Zhu Y, Guo M, Zhang L, Xu T, Wang L, Xu G (2016) Biomarker triplet NAMPT/VEGF/HER2 as a de novo detection panel for the diagnosis and prognosis of human breast cancer. Oncol Rep 35(1):454–462. https://doi.org/10.3892/or.2015.4391

Article  CAS  PubMed  Google Scholar 

Travelli C, Colombo G, Aliotta M, Fagiani F, Fava N, De Sanctis R, Grolla AA, Garcia JGN, Clemente N, Portararo P, Costanza M, Condorelli F, Colombo MP, Sangaletti S, Genazzani AA (2023) Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer. J Immunother Cancer 11(10):e007010. https://doi.org/10.1136/jitc-2023-007010

Article  PubMed  PubMed Central  Google Scholar 

Colombo G, Clemente N, Zito A, Bracci C, Colombo FS, Sangaletti S, Jachetti E, Ribaldone DG, Caviglia GP, Pastorelli L, De Andrea M, Naviglio S, Lucafò M, Stocco G, Grolla AA, Campolo M, Casili G, Cuzzocrea S, Esposito E, Malavasi F, Travelli C (2020) Neutralization of extracellular NAMPT (nicotinamide phosphoribosyltransferase) ameliorates experimental murine colitis. J Mol Med (Berlin, Germany) 98(4):595–612. https://doi.org/10.1007/s00109-020-01892-0

Article  CAS  Google Scholar 

Moro M, Balestrero FC, Grolla AA (2024) Pericytes: jack-of-all-trades in cancer-related inflammation. Front Pharmacol 15:1426033. https://doi.org/10.3389/fphar.2024.1426033

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee LL, Khakoo AY, Chintalgattu V (2019) Isolation and purification of murine cardic pericytes. J Vis Exp: JoVE. https://doi.org/10.3791/59571.10.3791/59571

Article  PubMed  Google Scholar 

Alvino VV, Mohammed KAK, Gu Y, Madeddu P (2023) Approaches for the isolation and long-term expansion of pericytes from human and animal tissues. Front Cardiov Med 9:1095141. https://doi.org/10.3389/fcvm.2022.1095141

Article  CAS  Google Scholar 

Abramsson A, Lindblom P, Betsholtz C (2003) Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Investig 112(8):1142–1151. https://doi.org/10.1172/JCI18549

Article  CAS  PubMed  PubMed Central