This work was supported by National Key R&D Program of China and Noncommunicable Chronic Diseases-National Science and Technology Major Project (2022YFA1104800, 2023ZD0506900), National Natural Science Foundation of China (82370514, 92468105, U24A20375, 32401144, 82472171), Beijing Natural Science Foundation (JQ23029, L246020, L244089, L234024, L234021), Beijing Nova Program (20220484100, 20230484448), Beijing Municipal Science & Technology Commission (Z231100007223001), Scientific and Technological Innovation project of China Academy of Chinese Medical Science (C12023C056YLL), the open research fund from State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital(BYSYSZKF2023023). The Innovation and Translation Fund of Peking University Third Hospital (BYSYZHKC2023106) and Elite Support Program (jyzc2024-04).