Novel Insights from Research Practice

Niedziela M.a· Szydlowski J.b· Dopierala M.c,d· Maldyk J.e· Klimecka I.a· Kurzawa P.c,d

Author affiliations

aDepartment of Pediatric Endocrinology and Rheumatology, Karol Jonscher’s Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland
bDepartment of Pediatric Otolaryngology, Karol Jonscher’s Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland
cDepartment of Pathology, Karol Jonscher’s Clinical Hospital, Poznan, Poland
dDepartment of Clinical Pathology, Poznan University of Medical Sciences, Poznan, Poland
eDivision of Pathomorphology, Children’s Clinical Hospital, Medical University of Warsaw, Warsaw, Poland

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Article / Publication Details

First-Page Preview

Received: January 02, 2022
Accepted: May 12, 2022
Published online: July 22, 2022

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: https://www.karger.com/PAT

Abstract

Introduction: Bartonella henselae infection leads to development of cat-scratch disease (CSD) but may also trigger of autoimmune thyroiditis (AIT). Case Presentation: We describe a 4-year-old boy with a severe fever of unknown etiology, disseminated neck lymphadenopathy, and a headache. Treatment with antibiotics was employed, but finally a left tonsillectomy, selective left lymphadenectomy, and immunophenotyping were performed to exclude lymphoma. Histologic examination excluded lymphoma but revealed CSD. IgG against B. henselae and Bartonella quintana was positive. A goiter was also found and positive anti-thyroid antibodies confirmed AIT. Two months later, the thyroid was not palpable, normal on ultrasound, and both anti-thyroid antibodies were negative. The full reversibility was documented, and 6-year follow-up showed that the patient remains disease free. Conclusion: This is the first report that AIT triggered by B. henselae/B. qunitana might be reversible if the pathogenetic factor is eliminated at an early stage of disease.

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References Hussein HM, Rahal EA. The role of viral infections in the development of autoimmune diseases. Crit Rev Microbiol. 2019;45(4):394–412. Massei F, Gori L, Taddeucci G, Macchia P, Maggiore G. Bartonella henselae infection associated with Guillain-Barre syndrome. Pediatr Infect Dis J. 2006;25:90–1. Saranac L, Zivanovic S, Bjelakovic B, Stamenkovic H, Novak M, Kamenov B. Why is the thyroid so prone to autoimmune disease? Horm Res Paediatr. 2011;75:157–65. Tomer Y. Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics. Annu Rev Pathol. 2014;9(1):147–56. Floreani A, Leung PSC, Gershwin ME. Environmental basis of autoimmunity. Clin Rev Allergy Immunol. 2016;50:287–300. Menconi F, Hasham A, Tomer Y. Environmental triggers of thyroiditis: hepatitis C and interferon-α. J Endocrinol Invest. 2011;34(1):78–84. Stefan M, Jacobson EM, Huber AK, Greenberg DA, Li CW, Skrabanek L, et al. Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism. J Biol Chem. 2011;286(36):31168–79. Akeno N, Smith EP, Stefan M, Huber AK, Zhang W, Keddache M, et al. IFN-α mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms. J Immunol. 2011;186(8):4693–706. Köhling HL, Plummer SF, Marchesi JR, Davidge KS, Ludgate M. The microbiota and autoimmunity: their role in thyroid autoimmune diseases. Clin Immunol. 2017;183:63–74. Tsukahara M, Tsuneoka H, Tateishi H, Fujita K, Uchida M. Bartonella infection associated with systemic juvenile rheumatoid arthritis. Clin Infect Dis. 2001;32:E22–3. Van Audenhove A, Verhoef G, Peetermans WE, Boogaerts M, Vandenberghe P. Autoimmune haemolytic anaemia triggered by Bartonella henselae infection: a case report. Br J Haematol. 2001;115:924–5. Hopp L, Eppes SC. Development of IgA nephritis following cat scratch disease in a 13-year-old boy. Pediatr Nephrol. 2004;19:682–4. Baylor P, Garoufi A, Karpathios T, Lutz J, Mogelof J, Moseley D. Transverse myelitis in 2 patients with Bartonella henselae infection (cat scratch disease). Clin Infect Dis. 2007;45:e42–5. Chiuri RM, Matronola MF, Di Giulio C, Comegna L, Chiarelli F, Blasetti A. Bartonella henselae infection associated with autoimmune thyroiditis in a child. Horm Res Paediatr. 2013;79:185–8. Kivity S, Agmon-Levin N, Blank M, Shoenfeld T. Infections and autoimmunity: friends or foes? Trends Immunol. 2009;30:409–14. Serranti D, Indolfi G, Nebbia G, Cananzi M, D’Antiga L, Ricci S, et al. Transient hypothyroidism and autoimmune thyroiditis in children with chronic hepatitis C treated with pegylated-interferon-α-2b and ribavirin. Pediatr Infect Dis J. 2018;37(4):287–91. Article / Publication Details

First-Page Preview

Received: January 02, 2022
Accepted: May 12, 2022
Published online: July 22, 2022

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: https://www.karger.com/PAT

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