Molecular Mechanisms of KSHV Latency Establishment and Maintenance

Cesarman E, Damania B, Krown SE, Martin J, Bower M, Whitby D. Kaposi sarcoma. Nat Rev Dis Primers. 2019;5(1):9. https://doi.org/10.1038/s41572-019-0060-9. (Epub 20190131 PubMed PMID: 30705286; PubMed Central PMCID: PMCPMC6685213).

Article  PubMed  PubMed Central  Google Scholar 

Goncalves PH, Uldrick TS, Yarchoan R. HIV-associated Kaposi sarcoma and related diseases. AIDS. 2017;31(14):1903–16. https://doi.org/10.1097/QAD.0000000000001567. (Epub 2017/06/14 PubMed PMID: 28609402).

Article  PubMed  Google Scholar 

Gottlieb GJ, Ragaz A, Vogel JV, Friedman-Kien A, Rywlin AM, Weiner EA, et al. A preliminary communication on extensively disseminated Kaposi’s sarcoma in young homosexual men. Am J Dermatopathol. 1981;3(2):111–4. https://doi.org/10.1097/00000372-198100320-00002. (PubMed PMID: 7270808).

Article  CAS  PubMed  Google Scholar 

Hymes KB, Cheung T, Greene JB, Prose NS, Marcus A, Ballard H, et al. Kaposi’s sarcoma in homosexual men-a report of eight cases. Lancet. 1981;2(8247):598–600. https://doi.org/10.1016/s0140-6736(81)92740-9. (PubMed PMID: 6116083).

Article  CAS  PubMed  Google Scholar 

Maurer T, Ponte M, Leslie K. HIV-associated Kaposi’s sarcoma with a high CD4 count and a low viral load. N Engl J Med. 2007;357(13):1352–3. https://doi.org/10.1056/NEJMc070508. (PubMed PMID: 17898112).

Article  CAS  PubMed  Google Scholar 

Labo N, Miley W, Benson CA, Campbell TB, Whitby D. Epidemiology of Kaposi’s sarcoma-associated herpesvirus in HIV-1-infected US persons in the era of combination antiretroviral therapy. AIDS. 2015;29(10):1217–25. https://doi.org/10.1097/QAD.0000000000000682. (PubMedPMID:26035321;PubMedCentralPMCID:PMCPMC6680245).

Article  CAS  PubMed  Google Scholar 

Yarchoan R, Uldrick TS. HIV-Associated Cancers and Related Diseases. N Engl J Med. 2018;378(22):2145. https://doi.org/10.1056/NEJMc1804812. (PubMed PMID: 29847760).

Article  PubMed  Google Scholar 

Russo JJ, Bohenzky RA, Chien MC, Chen J, Yan M, Maddalena D, et al. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A. 1996;93(25):14862–7 (PubMed PMID: 8962146).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong YK, Foreman K, Shin JW, Hirakawa S, Curry CL, Sage DR, et al. Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet. 2004;36(7):683–5. https://doi.org/10.1038/ng1383ng1383. (Epub 2004/06/29 PubMed PMID: 15220917).

Article  CAS  PubMed  Google Scholar 

Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, Makinen T, et al. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet. 2004;36(7):687–93. https://doi.org/10.1038/ng1384ng1384. (Epub 2004/06/29 PubMed PMID: 15220918).

Article  CAS  PubMed  Google Scholar 

Cheng F, Pekkonen P, Laurinavicius S, Sugiyama N, Henderson S, Gunther T, et al. KSHV-Initiated Notch Activation Leads to Membrane-Type-1 Matrix Metalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition. Cell Host Microbe. 2011;10(6):577–90 (S1931-3128(11)00364-7 Epub 2011/12/20 [pii] 10.1016/j.chom.2011.10.011. PubMed PMID: 22177562).

Article  CAS  PubMed  Google Scholar 

Tuohinto K, DiMaio TA, Kiss EA, Laakkonen P, Saharinen P, Karnezis T, et al. KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi’s sarcoma studies. Plos Pathogens. 2023;19(1):e1010753. https://doi.org/10.1371/journal.ppat.1010753. PubMed PMID: WOS:000935334400001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee MS, Yuan H, Jeon H, Zhu Y, Yoo S, Shi S. Human Mesenchymal Stem Cells of Diverse Origins Support Persistent Infection with Kaposi’s Sarcoma-Associated Herpesvirus and Manifest Distinct Angiogenic, Invasive, and Transforming Phenotypes. mBio. 2016;7(1):e02109-15. https://doi.org/10.1128/mBio.02109-15. Epub 20160126 PubMed PMID: 26814175; PubMed Central PMCID: PMCPMC4742711.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoo SM, Jang J, Yoo C, Lee MS. Kaposi’s sarcoma-associated herpesvirus infection of human bone-marrow-derived mesenchymal stem cells and their angiogenic potential. Adv Virol. 2014;159(9):2377–86. https://doi.org/10.1007/s00705-014-2094-3. (PubMedPMID:WOS:000342079800018).

Article  CAS  Google Scholar 

Parsons CH, Szomju B, Kedes DH. Susceptibility of human fetal mesencyhmal stem cells to Kaposi sarcoma-associated herpesvirus. Blood. 2004;104(9):2736–8. https://doi.org/10.1182/blood-2004-02-0693. (PubMedPMID:WOS:000224795700026).

Article  CAS  PubMed  Google Scholar 

Naipauer J, Rosario S, Gupta S, Premer C, Mendez-Solis O, Schlesinger M, et al. PDGFRA defines the mesenchymal stem cell Kaposi’s sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment. PLoS Pathog. 2019;15(12):e1008221. https://doi.org/10.1371/journal.ppat.1008221. (PubMed PMID: 31881074; PubMed Central PMCID: PMCPMC6980685).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dittmer DP. Transcription profile of Kaposi’s sarcoma-associated herpesvirus in primary Kaposi’s sarcoma lesions as determined by real-time PCR arrays. Cancer Research. 2003;63(9):2010–5 (PubMed PMID: WOS:000182640400003).

CAS  PubMed  Google Scholar 

Gottwein E, Corcoran DL, Mukherjee N, Skalsky RL, Hafner M, Nusbaum JD, et al. Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines. Cell Host Microbe. 2011;10(5):515–26 (Epub 2011/11/22. doi: S1931-3128(11)00331-3 [pii] 10.1016/j.chom.2011.09.012. PubMed PMID: 22100165; PubMed Central PMCID: PMC3222872).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tagawa T, Gao S, Koparde VN, Gonzalez M, Spouge JL, Serquina AP, et al. Discovery of Kaposi’s sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA. Proc Natl Acad Sci U S A. 2018;115(50):12805–10. https://doi.org/10.1073/pnas.1816183115. (Epub 2018/11/21 PubMed PMID: 30455306; PubMed Central PMCID: PMCPMC6294913).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toptan T, Abere B, Nalesnik MA, Swerdlow SH, Ranganathan S, Lee N, et al. Circular DNA tumor viruses make circular RNAs. Proc Natl Acad Sci USA. 2018;115(37):E8737–45. https://doi.org/10.1073/pnas.1811728115. (PubMedPMID:WOS:000444257200019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rivas C, Thlick AE, Parravicini C, Moore PS, Chang Y. Kaposi’s sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. J Virol. 2001;75(1):429–38. https://doi.org/10.1128/JVI.75.1.429-438.2001. (PubMed PMID: 11119611; PubMed Central PMCID: PMCPMC113935).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Speck SH, Ganem D. Viral latency and its regulation: lessons from the gamma-herpesviruses. Cell Host Microbe. 2010;8(1):100–15. https://doi.org/10.1016/j.chom.2010.06.014. (PubMedPMID:20638646;PubMedCentralPMCID:PMCPMC2914632).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ballestas ME, Chatis PA, Kaye KM. Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science. 1999;284(5414):641–4 (Epub 1999/04/24 PubMed PMID: 10213686).

Article  CAS  PubMed  Google Scholar 

Cotter MA 2nd, Robertson ES. The latency-associated nuclear antigen tethers the Kaposi’s sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells. Virology. 1999;264(2):254–64. https://doi.org/10.1006/viro.1999.9999S0042-6822(99)99999-3[pii]. (Epub 1999/11/24 PubMed PMID: 10562490).

Article  CAS  PubMed  Google Scholar 

Li Q, Zhou F, Ye F, Gao SJ. Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program. Virology. 2008;379(2):234–44. https://doi.org/10.1016/j.virol.2008.06.043S0042-6822(08)00436-4[pii]. (Epub 2008/08/08 PubMed PMID: 18684478; PubMed Central PMCID: PMC2626151).

Article  CAS  PubMed  Google Scholar 

Toth Z, Papp B, Brulois K, Choi YJ, Gao SJ, Jung JU. LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection. PLoS Pathog. 2016;12(9):e1005878. https://doi.org/10.1371/journal.ppat.1005878. (Epub 20160908 PubMed PMID: 27606464; PubMed Central PMCID: PMCPMC5015872).

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif