Bringing Balance: Immune Interactions Regulating Murine Gammaherpesvirus 68 Latency

Virgin HWt, Latreille P, Wamsley P, Hallsworth K, Weck KE, Dal Canto AJ, et al. Complete sequence and genomic analysis of murine gammaherpesvirus 68. J Virol. 1997;71(8):5894–904.

Blaskovic D, Stancekova M, Svobodova J, Mistrikova J. Isolation of five strains of herpesviruses from two species of free living small rodents. Acta Virol. 1980;24(6):468.

CAS  PubMed  Google Scholar 

Barton E, Mandal P, Speck SH. Pathogenesis and host control of gammaherpesviruses: Lessons from the mouse. Annu Rev Immunol. 2011;29:351–97.

Article  CAS  PubMed  Google Scholar 

Wang Y, Tibbetts SA, Krug LT. Conquering the host: determinants of pathogenesis learned from murine gammaherpesvirus 68. Ann Rev Virol. 2021;8(1):349–71.

Article  CAS  Google Scholar 

Gaspar M, May JS, Sukla S, Frederico B, Gill MB, Smith CM, et al. Murid herpesvirus-4 exploits dendritic cells to infect B cells. PLoS Pathog. 2011;7(11):e1002346.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flano E, Kim IJ, Woodland DL, Blackman MA. Gamma-herpesvirus latency is preferentially maintained in splenic germinal center and memory B cells. J Exp Med. 2002;196(10):1363–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roughan JE, Thorley-Lawson DA. The intersection of Epstein-Barr virus with the germinal center. J Virol. 2009;83(8):3968–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stebegg M, Kumar SD, Silva-Cayetano A, Fonseca VR, Linterman MA, Graca L. Regulation of the germinal center response. Front Immunol 2018;9:2469.

Willer DO, Speck SH. Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40. J Virol. 2005;79(5):2891.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babcock GJ, Decker LL, Freeman RB, Thorley-Lawson DA. Epstein-barr virus-infected resting memory B cells, not proliferating lymphoblasts, accumulate in the peripheral blood of immunosuppressed patients. J Exp Med. 1999;190(4):567–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

•Bussey KA, Murthy S, Reimer E, Chan B, Hatesuer B, Schughart K, et al. Endosomal toll-like receptors 7 and 9 cooperate in detection of murine gammaherpesvirus 68 infection. J Virol. 2019;93(3):e01173–18. The study demonstrates that TLR7 and TLR9 exhibit cooperativity while detecting and controlling MHV68 latency.

Pasare C, Medzhitov R. Toll-like receptors: Linking innate and adaptive immunity. Microbes Infect. 2004;6(15):1382–7.

Article  CAS  PubMed  Google Scholar 

Sartorius R, Trovato M, Manco R, D’Apice L, De Berardinis P. Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines. NPJ Vaccines. 2021;6(1):127.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duan T, Du Y, Xing C, Wang HY, Wang RF. Toll-like receptor signaling and its role in cell-mediated immunity. Front Immunol. 2022;13:812774.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gargano LM, Moser JM, Speck SH. Role for MyD88 signaling in murine gammaherpesvirus 68 latency. J Virol. 2008;82(8):3853–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu T, Zhang L, Joo D, Sun S-C. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017;2(1):17023.

Article  PubMed  PubMed Central  Google Scholar 

Brown HJ, Song MJ, Deng HY, Wu TT, Cheng GH, Sun R. NF-kappa B inhibits gammaherpesvirus lytic replication. J Virol. 2003;77(15):8532–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krug LT, Moser JM, Dickerson SM, Speck SH. Inhibition of NF-kB activation in vivo impairs establishment of gammaherpesvirus latency. PLoS Pathog. 2007;3:97–118.

Article  CAS  Google Scholar 

Krug LT, Collins CM, Gargano LM, Speck SH. NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency. J Virol. 2009;83(10):4732–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodrigues L, Filipe J, Seldon MP, Fonseca L, Anrather J, Soares MP, et al. Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase. EMBO J. 2009;28(9):1283–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frederico B, May JS, Efstathiou S, Stevenson PG. BAFF receptor deficiency limits gammaherpesvirus infection. J Virol. 2014;88(8):3965–75.

Article  PubMed  PubMed Central  Google Scholar 

••Cieniewicz B, Kirillov V, Daher I, Li X, Oldenburg DG, Dong Q, et al. IKKα-Mediated noncanonical NF-κB signaling is required to support murine gammaherpesvirus 68 latency in vivo. J Virol. 2022;96(10):e0002722. The study supports the role of non-canonical NF-kB signaling in establishment of MHV68 latency.

Stetson DB, Medzhitov R. Type I interferons in host defense. Immunity. 2006;25(3):373–81.

Article  CAS  PubMed  Google Scholar 

Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, et al. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J Virol. 2006;80(11):5338–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhat P, Leggatt G, Waterhouse N, Frazer IH. Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity. Cell Death Dis. 2017;8(6):e2836.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wack A, Terczynska-Dyla E, Hartmann R. Guarding the frontiers: The biology of type III interferons. Nat Immunol. 2015;16(8):802–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barton ES, Lutzke ML, Rochford R, Virgin HWt. Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency. J Virol. 2005;79(22):14149–60.

Mandal P, Krueger BE, Oldenburg D, Andry KA, Beard RS, White DW, et al. A gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality. PLoS Pathog. 2011;7(11):e1002371.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schwerk J, Kemper L, Bussey KA, Lienenklaus S, Weiss S, Čičin-Šain L, et al. Type I interferon signaling controls gammaherpesvirus latency in vivo. Pathogens (Basel, Switzerland). 2022;11(12):1554.

Tibbetts SA, van Dyk LF, Speck SH, Virgin HWt. Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus. J Virol. 2002;76(14):7125–32.

Steed AL, Barton ES, Tibbetts SA, Popkin DL, Lutzke ML, Rochford R, et al. Gamma interferon blocks gammaherpesvirus reactivation from latency. J Virol. 2006;80(1):192–200.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Honda K, Takaoka A, Taniguchi T. Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity. 2006;25(3):349–60.

Article  CAS  PubMed  Google Scholar 

Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011;472(7344):481–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goodwin MM, Canny S, Steed A, Virgin HW. Murine gammaherpesvirus 68 has evolved gamma interferon and stat1-repressible promoters for the lytic switch gene 50. J Virol. 2010;84(7):3711–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wood BM, Mboko WP, Mounce BC, Tarakanova VL. Mouse gammaherpesvirus-68 infection acts as a rheostat to set the level of type I interferon signaling in primary macrophages. Virology. 2013;443(1):123–33.

Article  CAS  PubMed  Google Scholar 

Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, et al. IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci USA. 2007;104(4):1371–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aricò E, Monque DM, D’Agostino G, Moschella F, Venditti M, Kalinke U, et al. MHV-68 producing mIFNα1 is severely attenuated in vivo and effectively protects mice against challenge with wt MHV-68. Vaccine. 2011;29(23):3935–44.

Article  PubMed  Google Scholar 

Sylvester PA, Jondle CN, Stoltz KP, Lanham J, Dittel BN, Tarakanova VL. Conserved gammaherpesvirus protein kinase counters the antiviral effects of myeloid cell-specific STAT1 expression to promote the establishment of splenic B cell latency. J Virol. 2021;95(17):e0085921.

Article  CAS  PubMed  Google Scholar 

Sylvester PA, Jondle CN, Schmalzriedt DL, Dittel BN, Tarakanova VL. T cell-specific STAT1 expression promotes lytic replication and supports the establishment of gammaherpesvirus latent reservoir in splenic B cells. mBio. 2022;13(4):e0210722. The study reveals that T-cell specific STAT1 activity promotes acute and persistent MHV68 replication in the lungs and also establishes latent viral reservoir in B cells.

Mboko WP, Olteanu H, Ray A, Xin G, Darrah EJ, Kumar SN, et al. Tumor suppressor interferon-regulatory factor 1 counteracts the germinal center reaction driven by a cancer-associated gammaherpesvirus. J Virol. 2016;90(6):2818–29.

Article  CAS  PubMed Central  Google Scholar 

Jondle CN, Johnson KE, Uitenbroek AA, Sylvester PA, Nguyen C, Cui W, et al. B cell-intrinsic expression of interferon regulatory factor 1 supports chronic murine gammaherpesvirus 68 infection. J Virol. 2020;94(13):e00399-20. The study highlights the role of B cell-intrinsic IRF-1 in the establishment of chronic infection in the spleen as well as attenuation of the MHV68-driven germinal center response.

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