4E-BP3 deficiency impairs dendritic cell activation and CD4+ T cell differentiation and attenuates α-myosin-specific T cell-mediated myocarditis in mice

Axelrod ML, Meijers WC, Screever EM, Qin J, Carroll MG, Sun X, Tannous E, Zhang Y, Sugiura A, Taylor BC, Hanna A, Zhang S, Amancherla K, Tai W, Wright JJ, Wei SC, Opalenik SR, Toren AL, Rathmell JC, Ferrell PB, Phillips EJ, Mallal S, Johnson DB, Allison JP, Moslehi JJ, Balko JM (2022) T cells specific for α-myosin drive immunotherapy-related myocarditis. Nature 611:818–826. https://doi.org/10.1038/s41586-022-05432-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baldeviano GC, Barin JG, Talor MV, Srinivasan S, Bedja D, Zheng D, Gabrielson K, Iwakura Y, Rose NR, Cihakova D (2010) Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. Circ Res 106:1646–1655. https://doi.org/10.1161/CIRCRESAHA.109.213157

Article  CAS  PubMed  Google Scholar 

Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235–238. https://doi.org/10.1038/nature04753

Article  CAS  PubMed  Google Scholar 

Van Der Borght K, Scott CL, Martens L, Sichien D, Van Isterdael G, Nindl V, Saeys Y, Boon L, Ludewig B, Gillebert TC, Lambrecht BN (2018) Myocarditis elicits dendritic cell and monocyte infiltration in the heart and self-antigen presentation by conventional type 2 dendritic cells. Front Immunol 9:2714. https://doi.org/10.3389/fimmu.2018.02714

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boughdad S, Latifyan S, Fenwick C, Bouchaab H, Suffiotti M, Moslehi JJ, Salem JE, Schaefer N, Nicod-Lalonde M, Costes J, Perreau M, Michielin O, Peters S, Prior JO, Obeid M (2021) 68Ga-DOTATOC PET/CT to detect immune checkpoint inhibitor-related myocarditis. J Immunother Cancer 9:e003594. https://doi.org/10.1136/jitc-2021-003594

Article  PubMed  PubMed Central  Google Scholar 

Cihakova D, Rose NR (2008) Pathogenesis of myocarditis and dilated cardiomyopathy. Adv Immunol 99:95–114. https://doi.org/10.1016/S0065-2776(08)00604-4

Article  CAS  PubMed  Google Scholar 

Eriksson U, Kurrer MO, Sonderegger I, Iezzi G, Tafuri A, Hunziker L, Suzuki S, Bachmaier K, Bingisser RM, Penninger JM, Kopf M (2003) Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. J Exp Med 197:323–331. https://doi.org/10.1084/jem.20021788

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eriksson U, Ricci R, Hunziker L, Kurrer MO, Oudit GY, Watts TH, Sonderegger I, Bachmaier K, Kopf M, Penninger JM (2003) Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med 9:1484–1490. https://doi.org/10.1038/nm960

Article  CAS  PubMed  Google Scholar 

Fujita R, Mizuno S, Sadahiro T, Hayashi T, Sugasawa T, Sugiyama F, Ono Y, Takahashi S, Ieda M (2023) Generation of a MyoD knock-in reporter mouse line to study muscle stem cell dynamics and heterogeneity. iScience 26:106592. https://doi.org/10.1016/j.isci.2023.106592

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gergely TG, Kucsera D, Tóth VE, Kovács T, Sayour NV, Drobni ZD, Ruppert M, Petrovich B, Ágg B, Onódi Z, Fekete N, Pállinger É, Buzás EI, Yousif LI, Meijers WC, Radovits T, Merkely B, Ferdinandy P, Varga ZV (2023) Characterization of immune checkpoint inhibitor-induced cardiotoxicity reveals interleukin-17A as a driver of cardiac dysfunction after anti-PD-1 treatment. Br J Pharmacol 180:740–761. https://doi.org/10.1111/bph.15984

Article  CAS  PubMed  Google Scholar 

Gong Q, Huang J, Wu Q (2022) Integrated single-cell and RNA sequencing analysis identifies key immune cell and dendritic cells associated genes participated in myocarditis. J Immunol Res 2022:8655343. https://doi.org/10.1155/2022/8655343

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hilligan KL, Ronchese F (2020) Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses. Cell Mol Immunol 17:587–599. https://doi.org/10.1038/s41423-020-0465-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsieh AC, Ruggero D (2010) Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer. Clin Cancer Res 16:4914–4920. https://doi.org/10.1158/1078-0432.CCR-10-0433

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji C, Roy MD, Golas J, Vitsky A, Ram S, Kumpf SW, Martin M, Barletta F, Meier WA, Hooper AT, Sapra P, Khan NK, Finkelstein M, Guffroy M, Buetow BS (2019) Myocarditis in cynomolgus monkeys following treatment with immune checkpoint inhibitors. Clin Cancer Res 25:4735–4748. https://doi.org/10.1158/1078-0432.CCR-18-4083

Article  CAS  PubMed  Google Scholar 

Kishimoto C, Hiraoka Y, Takamatsu N, Takada H, Kamiya H, Ochiai H (2003) An in vivo model of autoimmune post-coxsackievirus B3 myocarditis in severe combined immunodeficiency mouse. Cardiovasc Res 60:397–403. https://doi.org/10.1016/j.cardiores.2003.07.002

Article  CAS  PubMed  Google Scholar 

Li S, Tajiri K, Murakoshi N, Xu D, Yonebayashi S, Okabe Y, Yuan Z, Feng D, Inoue K, Aonuma K, Shimoda Y, Song Z, Mori H, Huang H, Aonuma K, Ieda M (2021) Programmed death-ligand 2 deficiency exacerbates experimental autoimmune myocarditis in mice. Int J Mol Sci 22:1426. https://doi.org/10.3390/ijms22031426

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li S, Xu D, Murakoshi N, Yuan Z (2024) Autoantibody profiling of patients with immune checkpoint inhibitor-associated myocarditis : a pilot study. Front Immunol. https://doi.org/10.3389/fimmu.2024.1423622

Article  PubMed  PubMed Central  Google Scholar 

Lucas JA, Menke J, Rabacal WA, Schoen FJ, Sharpe AH, Kelley VR (2008) Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. J Immunol 181:2513–2521

Article  CAS  PubMed  Google Scholar 

Lv HJ, Havari E, Pinto S, Gottumukkala RVSRK, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, Fletcher AL, Turley SJ, Wucherpfennig K, Kyewski B, Lipes MA (2011) Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans. J Clin Invest 121:1561–1573. https://doi.org/10.1172/JCI44583

Article  CAS  PubMed  PubMed Central  Google Scholar 

Machino-ohtsuka T, Tajiri K, Kimura T, Sakai S, Sato A, Yoshida T, Hiroe M, Yasutomi Y, Aonuma K, Imanaka-yoshida K (2014) Tenascin-C aggravates autoimmune myocarditis via dendritic cell activation and Th17 cell differentiation. J Am Hear Assoc 3:e001052. https://doi.org/10.1161/JAHA.114.001052

Article  CAS  Google Scholar 

Martineau Y, Azar R, Bousquet C, Pyronnet S (2013) Anti-oncogenic potential of the eIF4E-binding proteins. Oncogene 32:671–677. https://doi.org/10.1038/onc.2012.116

Article  CAS  PubMed  Google Scholar 

Myers JM, Cooper LT, Kem DC, Stavrakis S, Kosanke SD, Shevach EM, Fairweather D, Stoner JA, Cox CJ, Cunningham MW (2016) Cardiac myosin-Th17 responses promote heart failure in human myocarditis. JCI Insight 1:e85851. https://doi.org/10.1172/jci.insight.85851

Article  PubMed  PubMed Central  Google Scholar 

Nakagomi Y, Tajiri K, Shimada S, Li S, Inoue K, Murakata Y, Murata M, Sakai S, Sato K, Ieda M (2022) Immune checkpoint inhibitor-related myositis overlapping with myocarditis: an institutional case series and a systematic review of literature. Front Pharmacol 13:884776. https://doi.org/10.3389/fphar.2022.884776

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nindl V, Maier R, Ratering D, De Giuli R, Züst R, Thiel V, Scandella E, Di Padova F, Kopf M, Rudin M, Rülicke T, Ludewig B (2012) Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy. Eur J Immunol 42:2311–2321. https://doi.org/10.1002/eji.201142209

Article  CAS  PubMed  Google Scholar 

Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N, Honjo T (2001) Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291:319–322. https://doi.org/10.1126/science.291.5502.319

Article  CAS 

留言 (0)

沒有登入
gif