Beltra J-C, Manne S, Abdel-Hakeem MS, Kurachi M, Giles JR, Chen Z, Casella V, Ngiow SF, Khan O, Huang YJ, Yan P, Nzingha K, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, Wherry EJ (2020) Developmental relationships of four exhausted CD8(+) T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms. Immunity 52:825-841.e8. https://doi.org/10.1016/j.immuni.2020.04.014
Article CAS PubMed PubMed Central Google Scholar
Boengler K, Schulz R, Heusch G (2009) Loss of cardioprotection with ageing. Cardiovasc Res 83:247–261. https://doi.org/10.1093/cvr/cvp033
Article CAS PubMed Google Scholar
Brumberger ZL, Branch ME, Klein MW, Seals A, Shapiro MD, Vasu S (2022) Cardiotoxicity risk factors with immune checkpoint inhibitors. Cardio-Oncology 8:3. https://doi.org/10.1186/s40959-022-00130-5
Article PubMed PubMed Central Google Scholar
Chen C, Liu X, Chang C-Y, Wang HY, Wang R-F (2023) The interplay between T cells and cancer: the basis of immunotherapy. Genes (Basel). https://doi.org/10.3390/genes14051008
Article PubMed PubMed Central Google Scholar
Croft M, So T, Duan W, Soroosh P (2009) The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol Rev 229:173–191. https://doi.org/10.1111/j.1600-065X.2009.00766.x
Article CAS PubMed PubMed Central Google Scholar
Doehner W, von Haehling S, Anker SD (2015) Protective overweight in cardiovascular disease: moving from ‘paradox’ to ‘paradigm.’ Eur Heart J 36:2729–2732. https://doi.org/10.1093/eurheartj/ehv414
Dolladille C, Akroun J, Morice P-M, Dompmartin A, Ezine E, Sassier M, Da-Silva A, Plane A-F, Legallois D, L’Orphelin J-M, Alexandre J (2021) Cardiovascular immunotoxicities associated with immune checkpoint inhibitors: a safety meta-analysis. Eur Heart J 42:4964–4977. https://doi.org/10.1093/eurheartj/ehab618
Article CAS PubMed Google Scholar
Drobni ZD, Alvi RM, Taron J, Zafar A, Murphy SP, Rambarat PK, Mosarla RC, Lee C, Zlotoff DA, Raghu VK, Hartmann SE, Gilman HK, Gong J, Zubiri L, Sullivan RJ, Reynolds KL, Mayrhofer T, Zhang L, Hoffmann U, Neilan TG (2020) Association between immune checkpoint inhibitors with cardiovascular events and atherosclerotic plaque. Circulation 142:2299–2311. https://doi.org/10.1161/CIRCULATIONAHA.120.049981
Article CAS PubMed PubMed Central Google Scholar
Duma N, Abdel-Ghani A, Yadav S, Hoversten KP, Reed CT, Sitek AN, Enninga EAL, Paludo J, Aguilera JV, Leventakos K, Lou Y, Kottschade LA, Dong H, Mansfield AS, Manochakian R, Adjei AA, Dronca RS (2019) Sex Differences in tolerability to anti-programmed cell death protein 1 therapy in patients with metastatic melanoma and non-small cell lung cancer: are we all equal? Oncologist 24:e1148–e1155. https://doi.org/10.1634/theoncologist.2019-0094
Article CAS PubMed PubMed Central Google Scholar
Efentakis P, Choustoulaki A, Kwiatkowski G, Varela A, Kostopoulos IV, Tsekenis G, Ntanasis-Stathopoulos I, Georgoulis A, Vorgias CE, Gakiopoulou H, Briasoulis A, Davos CH, Kostomitsopoulos N, Tsitsilonis O, Dimopoulos MA, Terpos E, Chłopicki S, Gavriatopoulou M, Andreadou I (2024) Early microvascular coronary endothelial dysfunction precedes pembrolizumab-induced cardiotoxicity. Preventive role of high dose of atorvastatin. Basic Res Cardiol. https://doi.org/10.1007/s00395-024-01046-0
Gergely TG, Brenner GB, Nagy RN, Sayour NV, Makkos A, Kovácsházi C, Tian H, Schulz R, Giricz Z, Görbe A, Ferdinandy P (2023) Effects of bempedoic acid in acute myocardial infarction in rats: no cardioprotection and no hidden cardiotoxicity. Int J Mol Sci. https://doi.org/10.3390/ijms24021585
Article PubMed PubMed Central Google Scholar
Gergely TG, Drobni ZD, Kallikourdis M, Zhu H, Meijers WC, Neilan TG, Rassaf T, Ferdinandy P, Varga ZV (2024) Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure. Nat Rev Cardiol. https://doi.org/10.1038/s41569-023-00986-9
Gergely TG, Kucsera D, Tóth VE, Kovács T, Sayour NV, Drobni ZD, Ruppert M, Petrovich B, Ágg B, Onódi Z, Fekete N, Pállinger É, Buzás EI, Yousif LI, Meijers WC, Radovits T, Merkely B, Ferdinandy P, Varga ZV (2023) Characterization of immune checkpoint inhibitor-induced cardiotoxicity reveals interleukin-17A as a driver of cardiac dysfunction after anti-PD-1 treatment. Br J Pharmacol 180:740–761. https://doi.org/10.1111/bph.15984
Article CAS PubMed Google Scholar
Haj-Yehia E, Mincu RI, Korste S, Lampe L, Margraf SM, Michel L, Mahabadi AA, Ferdinandy P, Rassaf T, Totzeck M (2024) High neutrophil-to-lymphocyte ratio is associated with cancer therapy-related cardiovascular toxicity in high-risk cancer patients under immune checkpoint inhibitor therapy. Clin Res Cardiol 113:301–312. https://doi.org/10.1007/s00392-023-02327-9
Article CAS PubMed Google Scholar
Haslam A, Gill J, Prasad V (2020) Estimation of the percentage of US patients with cancer who are eligible for immune checkpoint inhibitor drugs. JAMA Netw open 3:e200423. https://doi.org/10.1001/jamanetworkopen.2020.0423
Article PubMed PubMed Central Google Scholar
Henning RJ (2021) Obesity and obesity-induced inflammatory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity. Am J Cardiovasc Dis 11:504–529
CAS PubMed PubMed Central Google Scholar
Heusch G (2022) Coronary blood flow in heart failure: cause, consequence and bystander. Basic Res Cardiol 117:1. https://doi.org/10.1007/s00395-022-00909-8
Article PubMed PubMed Central Google Scholar
Heusch G (2023) Cardioprotection in cardio-oncology: a case for concern? Cardiovasc Res 119:e144–e145. https://doi.org/10.1093/cvr/cvad111
Article CAS PubMed Google Scholar
Heusch G, Bøtker HE, Ferdinandy P, Schulz R (2023) Primordial non-responsiveness: a neglected obstacle to cardioprotection. Eur Heart J 44:1687–1689. https://doi.org/10.1093/eurheartj/ehad160
Jing Y, Zhang Y, Wang J, Li K, Chen X, Heng J, Gao Q, Ye Y, Zhang Z, Liu Y, Lou Y, Lin SH, Diao L, Liu H, Chen X, Mills GB, Han L (2021) Association between sex and immune-related adverse events during immune checkpoint inhibitor therapy. J Natl Cancer Inst 113:1396–1404. https://doi.org/10.1093/jnci/djab035
Article CAS PubMed Google Scholar
Kaboré EG, Guenancia C, Vaz-Luis I, Di Meglio A, Pistilli B, Coutant C, Cottu P, Lesur A, Petit T, Dalenc F, Rouanet P, Arnaud A, Arsene O, Ibrahim M, Wassermann J, Boileau-Jolimoy G, Martin A-L, Lemonnier J, André F, Arveux P (2019) Association of body mass index and cardiotoxicity related to anthracyclines and trastuzumab in early breast cancer: French CANTO cohort study. PLoS Med 16:e1002989. https://doi.org/10.1371/journal.pmed.1002989
Article CAS PubMed PubMed Central Google Scholar
Kichenadasse G, Miners JO, Mangoni AA, Rowland A, Hopkins AM, Sorich MJ (2020) Association between body mass index and overall survival with immune checkpoint inhibitor therapy for advanced non-small cell lung cancer. JAMA Oncol 6:512–518. https://doi.org/10.1001/jamaoncol.2019.5241
Kleinbongard P, Andreadou I (2024) Is there a mitochondrial protection via remote ischemic conditioning in settings of anticancer therapy cardiotoxicity? Curr Heart Fail Rep 21:292–304. https://doi.org/10.1007/s11897-024-00658-w
Article PubMed PubMed Central Google Scholar
Koene RJ, Prizment AE, Blaes A, Konety SH (2016) Shared risk factors in cardiovascular disease and cancer. Circulation 133:1104–1114. https://doi.org/10.1161/CIRCULATIONAHA.115.020406
Article PubMed PubMed Central Google Scholar
Korste S, Settelmeier S, Michel L, Odersky A, Stock P, Reyes F, Haj-Yehia E, Anker MS, Grüneboom A, Hendgen-Cotta UB, Rassaf T, Totzeck M (2023) Anthracycline therapy modifies immune checkpoint signaling in the heart. Int J Mol Sci 24:6052
Article CAS PubMed PubMed Central Google Scholar
Kucsera D, Ruppert M, Sayour NV, Tóth VE, Kovács T, Hegedűs ZI, Onódi Z, Fábián A, Kovács A, Radovits T, Merkely B, Pacher P, Ferdinandy P, Varga ZV (2024) NASH triggers cardiometabolic HFpEF in aging mice. GeroScience. https://doi.org/10.1007/s11357-024-01153-9
留言 (0)