Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16:223–37. https://doi.org/10.1038/s41581-019-0244-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

World Health Organization. Hypertension: Key Facts. 2023. https://www.who.int/news-room/fact-sheets/detail/hypertension. Accessed 22 Dec 2023.

Sattar N, Gaw A, Scherbakova O, Ford I, O’Reilly DS, Haffner SM, Isles C, Macfarlane PW, Packard CJ, Cobbe SM, et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary prevention study. Circulation. 2003;108:414–9. https://doi.org/10.1161/01.CIR.0000080897.52664.94.

Article  CAS  PubMed  Google Scholar 

Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, Lakka TA. Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol. 2002;156:1070–7. https://doi.org/10.1093/aje/kwf145.

Article  PubMed  Google Scholar 

Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, Taskinen MR, Groop L. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24:683–9. https://doi.org/10.2337/diacare.24.4.683.

Article  CAS  PubMed  Google Scholar 

Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288:2709–16.

Article  PubMed  Google Scholar 

Lekakis V, Papatheodoridis GV. Natural history of metabolic dysfunction-associated steatotic liver disease. Eur J Intern Med. 2024;122:3–10. https://doi.org/10.1016/j.ejim.2023.11.005.

Article  CAS  PubMed  Google Scholar 

Collaborators GBDD. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2023;402:203–34. https://doi.org/10.1016/S0140-6736(23)01301-6.

Article  Google Scholar 

Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14:88–98. https://doi.org/10.1038/nrendo.2017.151.

Article  PubMed  Google Scholar 

Burnier M, Damianaki A. Hypertension as cardiovascular risk factor in chronic kidney disease. Circ Res. 2023;132:1050–63. https://doi.org/10.1161/CIRCRESAHA.122.321762.

Article  CAS  PubMed  Google Scholar 

World Health Organization. Fact sheets. The top 10 causes of death. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. Retrieved on 10 Sep 2021.

Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int. 2011;80:1258–70. https://doi.org/10.1038/ki.2011.368.

Article  PubMed  Google Scholar 

World Health Organization. Cardiovascular diseases. https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1. Accessed 04 Dec 2024.

Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton AZ, Benjamin EJ, Benziger CP, et al. Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study. J Am Coll Cardiol. 2020;76:2982–3021. https://doi.org/10.1016/j.jacc.2020.11.010.

Article  PubMed  PubMed Central  Google Scholar 

Akbar Z, Fituri S, Ouagueni A, Alalwani J, Sukik A, Al-Jayyousi GF, Bassil M, Tayyem R. Associations of the MIND diet with cardiometabolic diseases and their risk factors: a systematic review. Diabetes Metab Syndr Obes. 2023;16:3353–71. https://doi.org/10.2147/DMSO.S427412.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petersen KS, Flock MR, Richter CK, Mukherjea R, Slavin JL, Kris-Etherton PM. Healthy dietary patterns for preventing cardiometabolic disease: the role of plant-based foods and animal products. Curr Dev Nutr. 2017;1. https://doi.org/10.3945/cdn.117.001289

Widmer RJ, Flammer AJ, Lerman LO, Lerman A. The Mediterranean diet, its components, and cardiovascular disease. Am J Med. 2015;128:229–38. https://doi.org/10.1016/j.amjmed.2014.10.014.

Article  PubMed  Google Scholar 

Filippou CD, Tsioufis CP, Thomopoulos CG, Mihas CC, Dimitriadis KS, Sotiropoulou LI, Chrysochoou CA, Nihoyannopoulos PI, Tousoulis DM. Dietary Approaches to Stop Hypertension (DASH) diet and blood pressure reduction in adults with and without hypertension: a systematic review and meta-analysis of randomized controlled trials. Adv Nutr. 2020;11:1150–60. https://doi.org/10.1093/advances/nmaa041.

Article  PubMed  PubMed Central  Google Scholar 

Ungvari Z, Kunutsor SK. Coffee consumption and cardiometabolic health: a comprehensive review of the evidence. Geroscience. 2024;46:6473–510. https://doi.org/10.1007/s11357-024-01262-5.

Article  PubMed  PubMed Central  Google Scholar 

Paterson KE, Myint PK, Jennings A, Bain LKM, Lentjes MAH, Khaw KT, Welch AA. Mediterranean diet reduces risk of incident stroke in a population with varying cardiovascular disease risk profiles. Stroke. 2018;49:2415–20. https://doi.org/10.1161/STROKEAHA.117.020258.

Article  PubMed  PubMed Central  Google Scholar 

Feart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues JF, Scarmeas N, Barberger-Gateau P. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA. 2009;302:638–48. https://doi.org/10.1001/jama.2009.1146.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cherian L, Wang Y, Holland T, Agarwal P, Aggarwal N, Morris MC. DASH and Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) diets are associated with fewer depressive symptoms over time. J Gerontol A Biol Sci Med Sci. 2021;76:151–6. https://doi.org/10.1093/gerona/glaa044.

Article  PubMed  Google Scholar 

de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation. 1999;99:779–85.

Article  PubMed  Google Scholar 

Parikh M, Netticadan T, Pierce GN. Flaxseed: its bioactive components and their cardiovascular benefits. Am J Physiol Heart Circ Physiol. 2018;314:H146–59. https://doi.org/10.1152/ajpheart.00400.2017.

Article  CAS  PubMed  Google Scholar 

Dinu M, Sofi F, Lotti S, Colombini B, Mattioli AV, Catapano AL, Casula M, Baragetti A, Wong ND, Steg PG, et al. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis. Eur J Prev Cardiol. 2024;31:1863–75. https://doi.org/10.1093/eurjpc/zwae184.

Article  PubMed  Google Scholar 

Qi X, Zhu H, Ya R, Huang H. Omega-3 polyunsaturated fatty acids supplements and cardiovascular disease outcome: a systematic review and meta-analysis on randomized controlled trials. Rev Cardiovasc Med. 2023;24:24. https://doi.org/10.31083/j.rcm2401024.

Article  PubMed  PubMed Central  Google Scholar 

Godos J, Micek A, Currenti W, Franchi C, Poli A, Battino M, Dolci A, Ricci C, Ungvari Z, Grosso G. Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies. Aging Clin Exp Res. 2024;36:171. https://doi.org/10.1007/s40520-024-02823-6.

Article  PubMed  PubMed Central  Google Scholar 

Bassett CM, Rodriguez-Leyva D, Pierce GN. Experimental and clinical research findings on the cardiovascular benefits of consuming flaxseed. Appl Physiol Nutr Metab. 2009;34:965–74. https://doi.org/10.1139/H09-087.

Article  CAS  PubMed  Google Scholar 

Sabet HR, Ahmadi M, Akrami M, Motamed M, Keshavarzian O, Abdollahi M, Rezaei M, Akbari H. Effects of flaxseed supplementation on weight loss, lipid profiles, glucose, and high-sensitivity C-reactive protein in patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials. Clin Cardiol. 2024;47:e24211. https://doi.org/10.1002/clc.24211.

Article  PubMed  PubMed Central  Google Scholar 

Shayan M, Kamalian S, Sahebkar A, Tayarani-Najaran Z. Flaxseed for health and disease: review of clinical trials. Comb Chem High Throughput Screen. 2020;23:699–722. https://doi.org/10.2174/1386207323666200521121708.

Article  CAS  PubMed  Google Scholar 

Caligiuri SP, Edel AL, Aliani M, Pierce GN. Flaxseed for hypertension: implications for blood pressure regulation. Curr Hypertens Rep. 2014;16:499. https://doi.org/10.1007/s11906-014-0499-8.

Article