Khan S, Chan YT, Revelo XS, Winer DA. The immune landscape of visceral adipose tissue during obesity and aging. Front Endocrinol (Lausanne). 2020;11:267.

Article  PubMed  Google Scholar 

Mei Q, Liu Z, Zuo H, Yang Z, Qu J. Idiopathic pulmonary fibrosis: an update on pathogenesis. Front Pharmacol. 2021;12:797292.

Article  PubMed  Google Scholar 

Campisi J, d’Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007;8(9):729–40.

Eom Y-W, Kim MA, Park SS, Goo MJ, Kwon HJ, Sohn S, et al. Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype. Oncogene. 2005;24(30):4765–77.

Article  PubMed  Google Scholar 

Demaria M, O’Leary MN, Chang J, Shao L, Liu S, Alimirah F, et al. Cellular senescence promotes adverse effects of chemotherapy and cancer relapse. Cancer Discov. 2017;7(2):165–76.

Article  PubMed  Google Scholar 

Childs BG, Durik M, Baker DJ, van Deursen JM. Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat Med. 2015;21(12):1424–35.

Article  PubMed  PubMed Central  Google Scholar 

Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest. 2013;123(3):966–72.

Article  PubMed  PubMed Central  Google Scholar 

Giroud J, Bouriez I, Paulus H, Pourtier A, Debacq-Chainiaux F, Pluquet O. Exploring the communication of the SASP: dynamic, interactive, and adaptive effects on the microenvironment. Int J Mol Sci. 2023;24(13). https://doi.org/10.3390/ijms241310788

Basisty N, Kale A, Jeon OH, Kuehnemann C, Payne T, Rao C, et al. A proteomic atlas of senescence-associated secretomes for aging biomarker development. PLoS Biol. 2020;18(1):e3000599.

Article  PubMed  PubMed Central  Google Scholar 

Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, et al. Cellular senescence mediates fibrotic pulmonary disease. Nat Commun. 2017;8:14532.

Article  PubMed  PubMed Central  Google Scholar 

Wells RG. Tissue mechanics and fibrosis. Biochim Biophys Acta. 2013;1832(7):884–90.

Article  PubMed  PubMed Central  Google Scholar 

Sicard D, Haak AJ, Choi KM, Craig AR, Fredenburgh LE, Tschumperlin DJ. Aging and anatomical variations in lung tissue stiffness. Am J Physiol Lung Cell Mol Physiol. 2018;314(6):L946–55.

Article  PubMed  PubMed Central  Google Scholar 

Booth AJ, Hadley R, Cornett AM, Dreffs AA, Matthes SA, Tsui JL, et al. Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation. Am J Respir Crit Care Med. 2012;186(9):866–76.

Article  PubMed  PubMed Central  Google Scholar 

Miyake K, Satomi N, Sasaki S. Elastic modulus of polystyrene film from near surface to bulk measured by nanoindentation using atomic force microscopy. Appl Phys Lett. 2006;89(3):031925.

Article  Google Scholar 

Ellis B, Smith R, editors. Polymers. CRC Press; 2008. https://doi.org/10.1201/9781420005707

Chakraborty M, Chu K, Shrestha A, Revelo XS, Zhang X, Gold MJ, et al. Mechanical stiffness controls dendritic cell metabolism and function. Cell Rep. 2021;34(2):108609.

Article  PubMed  Google Scholar 

Lee M, Chu K, Chakraborty M, Kotoulas N, Akbari M, Goh C, et al. PDMS hydrogel-coated tissue culture plates for studying the impact of substrate stiffness on dendritic cell function. STAR Protocols. 2022;3(2):101233.

Article  PubMed  PubMed Central  Google Scholar 

O’Connor RS, Hao X, Shen K, Bashour K, Akimova T, Hancock WW, et al. Substrate rigidity regulates human T cell activation and proliferation. J Immunol. 2012;189(3):1330–9.

Article  PubMed  Google Scholar 

Palchesko RN, Zhang L, Sun Y, Feinberg AW. Development of polydimethylsiloxane substrates with tunable elastic modulus to study cell mechanobiology in muscle and nerve. PLoS ONE. 2012;7(12):e51499.

Article  PubMed  PubMed Central  Google Scholar 

Szeto SG, Narimatsu M, Lu M, He X, Sidiqi AM, Tolosa MF, et al. YAP/TAZ Are mechanoregulators of TGF-β-Smad signaling and renal fibrogenesis. J Am Soc Nephrol. 2016;27(10):3117–28.

Article  PubMed  PubMed Central  Google Scholar 

Saruwatari L, Aita H, Butz F, Nakamura HK, Ouyang J, Yang Y, et al. Osteoblasts generate harder, stiffer, and more delamination-resistant mineralized tissue on titanium than on polystyrene, associated with distinct tissue micro- and ultrastructure. J Bone Miner Res. 2005;20(11):2002–16.

Article  PubMed  Google Scholar 

Sahin O, Magonov S, Su C, Quate CF, Solgaard O. An atomic force microscope tip designed to measure time-varying nanomechanical forces. Nat Nanotechnol. 2007;2(8):507–14.

Article  PubMed  Google Scholar 

Coppé J-P, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008;6(12):2853–68.

Article  PubMed  Google Scholar 

Gillet LC, Navarro P, Tate S, Röst H, Selevsek N, Reiter L, et al. Targeted data extraction of the MS/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis. Mol Cell Proteomics. 2012 Jun;11(6):O111.016717.

Collins BC, Hunter CL, Liu Y, Schilling B, Rosenberger G, Bader SL, et al. Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry. Nat Commun. 2017;8(1):291.

Article  PubMed  PubMed Central  Google Scholar 

Schilling B, Gibson BW, Hunter CL. Generation of high-quality SWATH® acquisition data for label-free quantitative proteomics studies using TripleTOF® mass spectrometers. Methods Mol Biol. 2017;1550:223–33.

Article  PubMed  PubMed Central  Google Scholar 

Coppé J-P, Desprez P-Y, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010;5:99–118.

Article  PubMed  PubMed Central  Google Scholar 

Cohn RL, Gasek NS, Kuchel GA, Xu M. The heterogeneity of cellular senescence: insights at the single-cell level. Trends Cell Biol. 2023;33(1):9–17.

Article  PubMed  Google Scholar 

Ciotlos S, Wimer L, Campisi J, Melov S. A single cell time course of senescence uncovers discrete cell trajectories and transcriptional heterogeneity. BioRxiv. 2023. https://doi.org/10.1101/2023.02.17.529001.

Article  Google Scholar 

Neri F, Zheng S, Watson M, Desprez P-Y, Gerencser AA, Campisi J, et al. Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrest. BioRxiv. 2024. https://doi.org/10.1101/2024.06.22.600200.

Article  PubMed  PubMed Central  Google Scholar 

Hedges LV, Olkin I. Tests of statistical significance of combined results. Statistical Methods for Meta-Analysis. Elsevier; 1985; pp 27–46.

Fragoulis A, Tohidnezhad M, Kubo Y, Wruck CJ, Craveiro RB, Bock A, et al. The contribution of the nrf2/are system to mechanotransduction in musculoskeletal and periodontal tissues. Int J Mol Sci. 2023 Apr;24(9). https://doi.org/10.3390/ijms24097722

Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, et al. Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Nature. 2019;573(7772):69–74.

Article  PubMed  PubMed Central  Google Scholar 

Koloko Ngassie ML, De Vries M, Borghuis T, Timens W, Sin DD, Nickle D, et al. Age-associated differences in the human lung extracellular matrix. Am J Physiol Lung Cell Mol Physiol. 2023;324(6):L799-814.

Article  PubMed  PubMed Central  Google Scholar 

Elzi DJ, Song M, Hakala K, Weintraub ST, Shiio Y. Wnt antagonist SFRP1 functions as a secreted mediator of senescence. Mol Cell Biol. 2012;32(21):4388–99.

Article  PubMed  PubMed Central  Google Scholar 

Nakamura T, Hosoyama T, Murakami J, Samura M, Ueno K, Kurazumi H, et al. Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells. Biochem Biophys Res Commun. 2017;487(3):653–9.

Article  PubMed  Google Scholar 

Tan J-K, Jaafar F, Makpol S. Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol. BMC Complement Altern Med. 2018;18(1):314.

Article  PubMed  PubMed Central