Importance of rectal over colon status in ulcerative colitis remission: the role of microinflammation and mucosal barrier dysfunction in relapse

Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet. 2007;369:1641–57. https://doi.org/10.1016/S0140-6736(07)60751-X.

Article  CAS  PubMed  Google Scholar 

Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med. 2009;361:2066–78. https://doi.org/10.1056/NEJMra0804647.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ek WE, D’Amato M, Halfvarson J. The history of genetics in inflammatory bowel disease. Ann of Gastroenterol. 2014;27:294–303.

Google Scholar 

Ungaro R, Mehandru S, Allen PB, et al. Ulcerative colitis. Lancet. 2017;389:1756–70. https://doi.org/10.1016/S0140-6736(16)32126-2.

Article  PubMed  Google Scholar 

Robert ME, Skacel M, Ullman T, et al. Patterns of colonic involvement at initial presentation in ulcerative colitis. a retrospective study of 46 newly diagnosed cases. Am J Clin Pathol. 2004;122:94–9.

Article  PubMed  Google Scholar 

Le Berre C, Honap S, Peyrin-Biroulet L. Ulcerative colitis. Lancet. 2023;402:571–84. https://doi.org/10.1016/S0140-6736(23)00966-2.

Article  PubMed  Google Scholar 

Sagami S, Kobayashi T, Aihara K, et al. Transperineal ultrasound predicts endoscopic and histological healing in ulcerative colitis. Aliment Pharmacol Ther. 2020;51:1373–83. https://doi.org/10.1111/apt.15767.

Article  PubMed  Google Scholar 

Katsandegwaza B, Horsnell W, Smith K. Inflammatory bowel disease: a review of pre-clinical murine models of human disease. Int J Mol Sci. 2022;23(16):9344.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogino H, Nakamura K, Ihara E, et al. CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model. Dig Dis Sci. 2011;56:376–86. https://doi.org/10.1007/s10620-010-1286-2.

Article  CAS  PubMed  Google Scholar 

Nishihara Y, Ogino H, Tanaka M, et al. Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis. Sci Rep. 2021;11:13743. https://doi.org/10.1038/s41598-021-92870-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Willing BP, Dicksved J, Halfvarson J, et al. A Pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology. 2010;139(1844–1854): e1. https://doi.org/10.1053/j.gastro.2010.08.049.

Article  Google Scholar 

Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30:2114–20. https://doi.org/10.1093/bioinformatics/btu170.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li B, Dewey CN. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics. 2011;12:323. https://doi.org/10.1186/1471-2105-12-323.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139–40. https://doi.org/10.1093/bioinformatics/btp616.

Article  CAS  PubMed  Google Scholar 

Komori K, Ihara E, Minoda Y, et al. The altered mucosal barrier function in the duodenum plays a role in the pathogenesis of functional dyspepsia. Dig Dis Sci. 2019;64:3228–39. https://doi.org/10.1007/s10620-019-5470-8.

Article  CAS  PubMed  Google Scholar 

Koizumi H, Suzuki H, Ohbuchi T, et al. Increased permeability of the epithelium of middle ear cholesteatoma. Clin Otolaryngol. 2015;40:106–14. https://doi.org/10.1111/coa.12332.

Article  CAS  PubMed  Google Scholar 

Iboshi Y, Nakamura K, Fukaura K, et al. Increased IL-17A/IL-17F expression ratio represents the key mucosal T helper/regulatory cell-related gene signature paralleling disease activity in ulcerative colitis. J Gastroenterol. 2017;52:315–26. https://doi.org/10.1007/s00535-016-1221-1.

Article  CAS  PubMed  Google Scholar 

Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009;9:799–809. https://doi.org/10.1038/nri2653.

Article  CAS  PubMed  Google Scholar 

Ishigami H, Matsumura T, Kasamatsu S, et al. Endoscopy-guided evaluation of duodenal mucosal permeability in functional dyspepsia. Clin Transl Gastroenterol. 2017;8: e83. https://doi.org/10.1038/ctg.2017.12.

Article  PubMed  PubMed Central  Google Scholar 

Zihni C, Mills C, Matter K, et al. Tight junctions: from simple barriers to multifunctional molecular gates. Nat Rev Mol Cell Biol. 2016;17:564–80. https://doi.org/10.1038/nrm.2016.80.

Article  CAS  PubMed  Google Scholar 

Čužić S, Antolić M, Ognjenović A, et al. Claudins: Beyond tight junctions in human IBD and Murine Models ibid. Front Pharmacol. 2021;12: 682614. https://doi.org/10.3389/fphar.2021.682614.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luettig J, Rosenthal R, Barmeyer C, et al. Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation. Tissue Barriers. 2015;3: e977176. https://doi.org/10.4161/21688370.2014.977176.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oshima T, Miwa H, Joh T. Changes in the expression of claudins in active ulcerative colitis. J Gastroenterol Hepatol. 2008;23(Suppl 2):S146–50. https://doi.org/10.1111/j.1440-1746.2008.05405.x.

Article  CAS  PubMed  Google Scholar 

Ahmad R, Kumar B, Thapa I, et al. Claudin-2 protects against colitis-associated cancer by promoting colitis-associated mucosal healing. J Clin Invest. 2023. https://doi.org/10.1172/JCI170771.

Article  PubMed  PubMed Central  Google Scholar 

Ahmad R, Chaturvedi R, Olivares-Villagomez D, et al. Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis. Mucosal Immunol. 2014;7:1340–53. https://doi.org/10.1038/mi.2014.21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmad R, Sorrell MF, Batra SK, et al. Gut permeability and mucosal inflammation: bad, good or context dependent. Mucosal Immunol. 2017;10:307–17. https://doi.org/10.1038/mi.2016.128.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martini E, Krug SM, Siegmund B, et al. Mend Your Fences: The epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell Mol Gastroenterol Hepatol. 2017;4:33–46. https://doi.org/10.1016/j.jcmgh.2017.03.007.

Article  PubMed  PubMed Central  Google Scholar 

Zuo L, Kuo WT, Turner JR. Tight junctions as targets and effectors of mucosal immune homeostasis. Cell Mol Gastroenterol Hepatol. 2020;10:327–40. https://doi.org/10.1016/j.jcmgh.2020.04.001.

Article  PubMed  PubMed Central  Google Scholar 

Mowat AM, Agace WW. Regional specialization within the intestinal immune system. Nat Rev Immunol. 2014;14:667–85. https://doi.org/10.1038/nri3738.

Article  CAS  PubMed 

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