Cancer in Parkinson’s Disease: An Approximation to the Main Risk Factors

Neurodegenerative Diseases

Rosas I.a· Morís G.b,c· Coto E.a,c· Blázquez M.b,c· Suárez E.b,c· García-Fernández C.b,c· Siso P.b· Martínez C.c,d· Pérez-Oliveira S.a· Álvarez V.a,c· Menéndez-González M.b,c

Author affiliations

aLaboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain
bServicio de Neurología, Hospital Universitario Central de Asturias, Oviedo, Spain
cInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
dServicio de Neurología, Hospital Universitario de Cabueñes, Gijón, Spain

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Article / Publication Details

First-Page Preview

Abstract of Research Article

Received: May 18, 2021
Accepted: October 18, 2021
Published online: October 21, 2021
Issue release date: Published online first

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: https://www.karger.com/NDD

Abstract

Background: Many evidences suggest a pathological link between neurodegenerative diseases and cancer. In fact, several epidemiologic studies indicate a decreased incidence of most cancer types in Parkinson’s disease (PD) patients and some PD genes are involved in cancer networks. Objective: The aim of this study is to assess the influence of several factors in the risk of cancer in a cohort of 753 PD patients and to study how these variables interact with each other. Methods: We analyzed the effect of gender, tobacco, alcohol, type of PD (genetic or idiopathic PD), and two genetic variants, previously associated with cancer, rs5848-GRN and rs1042522-TP53. Results: A higher age at PD onset was observed in patients who develop cancer before PD (p < 0.001). Alcohol consumption was a risk factor to develop cancer in PD patients (p = 0.011), while smoking was not a cancer risk factor in our cohort (p = 0.098). Among the genetic factors, the genotype TT GRN-rs5848 was statistically more frequent in PD patients without cancer (p = 0.05). Conclusions: Our study identified several factors, genetic and nongenetic, which contribute to the risk for cancer in PD.

© 2021 S. Karger AG, Basel

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First-Page Preview

Abstract of Research Article

Received: May 18, 2021
Accepted: October 18, 2021
Published online: October 21, 2021
Issue release date: Published online first

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: https://www.karger.com/NDD

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