Allavena P, Belgiovine C, D’Incalci M, et al. 2022 Effects of the anti-tumour agents trabectedin and lurbinectedin on immune cells of the tumour microenvironment. Front. Oncol. 12 851790

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anderson NR, Minutolo NG, Klichinsky M, et al. 2021 Macrophage-based approaches for cancer immunotherapy. Cancer Res. 81 1201–1208

Article  CAS  PubMed  Google Scholar 

Anfray C, Ummarino A, Allavena P, et al. 2020 Current strategies to target tumour-associated-macrophages to improve anti-tumor immune responses. Cells 9 46

Article  CAS  Google Scholar 

Argyle D and Kitamura T 2018 Targeting macrophage-recruiting chemokines as a novel therapeutic strategy to prevent the progression of solid tumours. Front. Immunol. 9 2629

Article  PubMed  PubMed Central  Google Scholar 

Belgiovine C, Bello E, Liguori M, et al. 2017 Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models. Br. J. Cancer 117 628–638

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bercovici N, Guérin MV, Trautmann A, et al. 2019 The remarkable plasticity of macrophages: A chance to fight cancer. Front. Immunol. 10 1563

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boutilier AJ and Elsawa SF 2021 Macrophage polarization states in the tumour microenvironment. Int. J. Mol Sci. 22 6995

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai H, Zhang Y, Wang J, et al. 2021 Defects in macrophage reprogramming in cancer therapy: the negative impact of PD-L1/PD-1. Front. Immunol. 12 690869

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canton J 2014 Phagosome maturation in polarized macrophages. J. Leukoc. Biol. 96 729–738

Article  PubMed  Google Scholar 

Chen Y, Yu Z, Tan X, et al. 2021 CAR-macrophage: A new immunotherapy candidate against solid tumors. Biomed. Pharmacother. 139 111605

Article  CAS  PubMed  Google Scholar 

Conde J, Bao C, Tan Y, et al. 2015 Dual targeted immunotherapy via in vivo delivery of biohybrid RNAi-peptide nanoparticles to tumour-associated macrophages and cancer cells. Adv. Funct. Mater. 25 4183–4194

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coussens LM, Zitvogel L and Palucka AK 2013 Neutralizing tumour-promoting chronic inflammation: a magic bullet? Science 339 286–291

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dumoulin DW, Visser S, Cornelissen R, et al. 2022 Renal toxicity from pemetrexed and pembrolizumab in the era of combination therapy in patients with metastatic nonsquamous cell NSCLC. Eur. J. Cancer 172 357–366

Article  CAS  PubMed  Google Scholar 

Fujiwara T, Chandler A, Yoshida A, et al. 2021 CSF1/CSF1R signaling inhibitor pexidartinib (PLX3397) reprograms tumour-associated macrophages and stimulates T-cell infiltration in the sarcoma microenvironment. Mol. Cancer Ther. 20 1388–1399

Article  CAS  PubMed  PubMed Central  Google Scholar 

Germano G, Frapolli R, Belgiovine C, et al. 2013 Role of macrophage targeting in the anti-tumour activity of trabectedin. Cancer Cell 23 249–262

Article  CAS  PubMed  Google Scholar 

Gordon S 2003 Alternative activation of macrophages. Nat. Rev. Immunol. 3 23–35

Article  CAS  PubMed  Google Scholar 

Gustafson HH, Holt-Casper D, Ghandehari H, et al. 2015 Nanoparticle uptake: the phagocyte problem. Nano Today 10 487–510

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haber T, Flores L, Cao P, et al. 2020 Specific targeting of ovarian tumour-associated macrophages by large, anionic nanoparticles. Proc. Natl. Acad. Sci. USA 117 19737–19745

Article  CAS  PubMed  PubMed Central  Google Scholar 

He Z and Zhang S 2021 Tumour-associated macrophages and their functional transformation in the hypoxic tumour microenvironment. Front. Immunol. 12 741305

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hourani T, Holden JA, O’Brien-Simpson NM, et al. 2021 Tumour-associated macrophages: origin, recruitment, phenotypic diversity, and targeting. Front. Oncol. 11 788365

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hume DA and MacDonald KPA 2012 Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signalling. Blood 119 1810–1820

Article  CAS  PubMed  Google Scholar 

Jakubzick CV, Randolph GJ and Henson PM 2017 Monocyte differentiation and antigen-presenting functions. Nat. Rev. Immunol. 17 349–362

Article  CAS  PubMed  Google Scholar 

Jiang P, Lagenaur CF and Narayanan V 1999 Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J. Biol. Chem. 274 559–562

Article  CAS  PubMed  Google Scholar 

Lampiasi N, Russo R and Zito F 2016 The alternative faces of macrophage generate osteoclasts. Biomed. Res. Int. 2016 9089610

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larsen AK, Galmarini CM and D’Incalci M 2016 Trabectedin mechanism of action: what’s new? Cancer Chemother. Pharmacol. 77 663–671

Article  CAS  PubMed  Google Scholar 

Li X, Yao W, Chen P, et al. 2017 Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma. Gut 66 157–167

Article  CAS  PubMed  Google Scholar 

Li G, Liu D, Qi X, et al. 2018 Nanoliposome C6-ceramide increases the anti-tumour immune response and slows growth of liver tumours in mice. Gastroenterology 154 1024-1036.e9

Article  CAS  PubMed  Google Scholar 

Li C, Xu X, Wang J, et al. 2021 Tumour-associated macrophages: potential therapeutic strategies and future prospects in cancer. J. Immunother. Cancer 9 e001314

Article  Google Scholar 

Li Z, Ding Y, Liu J, et al. 2022 Depletion of tumour-associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumour recurrence treatment. Nat. Commun. 13 1845

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin Y, Xu J and Lan H 2019 Tumour-associated macrophages in tumour metastasis: biological roles and clinical therapeutic applications. J. Hematol. Oncol. 12 76

Article  PubMed  PubMed Central  Google Scholar 

MacParland SA, Tsoi KM, Manuel J, et al. 2017 Phenotype determines nanoparticle uptake by human macrophages from liver and blood. ACS Nano 11 2428–2443

Article  CAS  PubMed  Google Scholar 

Mantovani A, Marchesi F, Allavena P, et al. 2021 Tumour-associated myeloid cells: diversity and therapeutic targeting. Cell Mol. Immunol. 18 566–578

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mantovani A, Allavena P, Marchesi F, et al. 2022 Macrophages as tools and targets in cancer therapy. Nat. Rev. Drug Discov. 21 799–820

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moreau MF, Guillet C, Massin P, et al. 2007 Comparative effects of five bisphosphonates on apoptosis of macrophage cells in vitro. Biochem. Pharmacol. 73 718–723

Article  CAS  PubMed  Google Scholar 

Murray PJ, Allen JE, Biswas SK, et al. 2014 Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41 14–20

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nishida-Aoki N and Gujral TS 2022 Polypharmacologic reprogramming of tumour-associated macrophages toward an inflammatory phenotype. Cancer Res. 82 433–446

Article  CAS  PubMed